Roles of Mesenchymal Cells in the Lung: From Lung Development to Chronic Obstructive Pulmonary Disease.
Airway Remodeling
/ genetics
Cell Differentiation
/ genetics
Epithelial-Mesenchymal Transition
/ genetics
Epithelium
/ growth & development
Humans
Lung
/ growth & development
Mesenchymal Stem Cells
/ cytology
Organogenesis
/ genetics
Pulmonary Disease, Chronic Obstructive
/ genetics
Respiratory Mucosa
/ growth & development
COPD
development
lung
mesenchyme
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
09 12 2021
09 12 2021
Historique:
received:
06
11
2021
revised:
02
12
2021
accepted:
07
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
18
1
2022
Statut:
epublish
Résumé
Mesenchymal cells are an essential cell type because of their role in tissue support, their multilineage differentiation capacities and their potential clinical applications. They play a crucial role during lung development by interacting with airway epithelium, and also during lung regeneration and remodeling after injury. However, much less is known about their function in lung disease. In this review, we discuss the origins of mesenchymal cells during lung development, their crosstalk with the epithelium, and their role in lung diseases, particularly in chronic obstructive pulmonary disease.
Identifiants
pubmed: 34943975
pii: cells10123467
doi: 10.3390/cells10123467
pmc: PMC8700565
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Cell. 2006 Jan 27;124(2):267-73
pubmed: 16439203
Genome Biol. 2001;2(3):REVIEWS3005
pubmed: 11276432
Stem Cell Res Ther. 2020 Feb 13;11(1):60
pubmed: 32054512
Dev Biol. 2003 Jun 1;258(1):169-84
pubmed: 12781691
Cell Prolif. 2004 Feb;37(1):89-96
pubmed: 14871239
Am J Respir Crit Care Med. 2018 Jul 15;198(2):175-186
pubmed: 29554438
Nature. 2020 Nov;587(7835):619-625
pubmed: 33208946
Cell Stem Cell. 2009 Jun 5;4(6):525-34
pubmed: 19497281
J Exp Med. 2007 Dec 24;204(13):3173-81
pubmed: 18056286
Eur Respir J. 2015 May;45(5):1258-72
pubmed: 25745049
Sci Rep. 2015 Mar 04;5:8733
pubmed: 25736434
Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E974-E981
pubmed: 29339516
Nature. 1995 Jul 27;376(6538):337-41
pubmed: 7630400
Lancet. 2017 May 13;389(10082):1931-1940
pubmed: 28513453
Lancet Respir Med. 2019 Apr;7(4):358-364
pubmed: 30765254
Nat Commun. 2019 Jan 3;10(1):37
pubmed: 30604742
N Engl J Med. 2000 Dec 28;343(26):1969-70; author reply 1970-1
pubmed: 11186675
J Cell Biochem. 1984;26(2):117-25
pubmed: 6396310
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12771-5
pubmed: 19625615
Am J Respir Cell Mol Biol. 2020 Feb;62(2):256-266
pubmed: 31486675
Int J Chron Obstruct Pulmon Dis. 2017 Oct 16;12:3017-3027
pubmed: 29081655
Ann Am Thorac Soc. 2019 Jun;16(6):657-668
pubmed: 30917290
PLoS Genet. 2009 Mar;5(3):e1000421
pubmed: 19300482
Front Bioeng Biotechnol. 2019 Nov 12;7:318
pubmed: 31781555
Lancet. 2009 Aug 29;374(9691):733-43
pubmed: 19716966
Am J Public Health Nations Health. 1964 Nov;54:1856-63
pubmed: 14227947
Pflugers Arch. 2017 Jan;469(1):135-147
pubmed: 27921210
Semin Cancer Biol. 2012 Oct;22(5-6):361-8
pubmed: 22613485
Ann Am Thorac Soc. 2014 Dec;11 Suppl 5:S252-8
pubmed: 25525728
Eur Respir J. 2008 Aug;32(2):285-95
pubmed: 18321928
Cell Stem Cell. 2014 Aug 7;15(2):123-38
pubmed: 25105578
J Clin Invest. 2009 Jun;119(6):1420-8
pubmed: 19487818
J Thorac Dis. 2018 May;10(Suppl 12):S1332-S1354
pubmed: 29928517
Int J Chron Obstruct Pulmon Dis. 2014 Aug 27;9:871-88
pubmed: 25210449
Dev Cell. 2022 Jul 11;57(13):1598-1614.e8
pubmed: 35679862
World J Stem Cells. 2020 Dec 26;12(12):1474-1491
pubmed: 33505596
Development. 2004 Oct;131(19):4637-50
pubmed: 15358668
Int J Biochem Cell Biol. 2020 Aug;125:105775
pubmed: 32473924
Nat Commun. 2020 Jul 16;11(1):3559
pubmed: 32678092
Nat Rev Dis Primers. 2015 Dec 03;1:15076
pubmed: 27189863
Cold Spring Harb Perspect Biol. 2018 Jan 2;10(1):
pubmed: 28246184
ERJ Open Res. 2021 Jun 07;7(2):
pubmed: 34109247
Chest. 2013 Jun;143(6):1590-1598
pubmed: 23172272
Am J Physiol. 1981 Oct;241(4):G275-88
pubmed: 7032321
Cell Tissue Res. 2017 Mar;367(3):427-444
pubmed: 28144783
Life Sci. 2021 Aug 1;278:119510
pubmed: 33865879
Stem Cells. 2021 Oct;39(10):1382-1394
pubmed: 34048616
Annu Rev Pharmacol Toxicol. 2006;46:451-80
pubmed: 16402912
J Allergy Clin Immunol. 2016 Jul;138(1):16-27
pubmed: 27373322
Cell. 2016 Jul 14;166(2):451-467
pubmed: 27419872
Am J Respir Crit Care Med. 2001 Aug 1;164(3):474-7
pubmed: 11500353
Int J Chron Obstruct Pulmon Dis. 2019 Jul 18;14:1603-1610
pubmed: 31409985
Am J Pathol. 2016 Oct;186(10):2519-31
pubmed: 27555112
Development. 2014 Jan;141(2):296-306
pubmed: 24353064
Dev Biol. 2006 Mar 1;291(1):67-82
pubmed: 16414041
N Engl J Med. 2011 Oct 27;365(17):1567-75
pubmed: 22029978
Curr Opin Genet Dev. 2015 Jun;32:98-105
pubmed: 25796078
Nat Commun. 2019 Feb 27;10(1):963
pubmed: 30814501
Nature. 2015 Oct 22;526(7574):578-82
pubmed: 26436454
Nature. 1999 Feb 18;397(6720):617-21
pubmed: 10050855
Nat Genet. 2010 Jan;42(1):36-44
pubmed: 20010834
Genes Dev. 1995 Sep 1;9(17):2105-16
pubmed: 7657163
J Cell Physiol. 2018 Dec;233(12):9099-9109
pubmed: 29943820
Biomolecules. 2020 Jan 17;10(1):
pubmed: 31963453
Thorax. 2013 May;68(5):410-20
pubmed: 23299965
Trans R Soc Trop Med Hyg. 2008 Sep;102(9):843-51
pubmed: 18639310
Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L197-L210
pubmed: 32401672
Eur Respir Rev. 2018 Oct 3;27(149):
pubmed: 30282634
BMC Pulm Med. 2014 May 26;14:90
pubmed: 24886452
Am J Physiol. 1999 Aug;277(2):L412-22
pubmed: 10444536
Nature. 2015 Dec 3;528(7580):127-31
pubmed: 26580007
Nat Med. 2014 Aug;20(8):822-32
pubmed: 25100528
Sci Rep. 2018 Feb 22;8(1):3502
pubmed: 29472603
Dev Biol. 1993 Aug;158(2):555-9
pubmed: 8344470
Dev Dyn. 2009 Nov;238(11):2813-22
pubmed: 19842186
Sci Adv. 2020 Jul 08;6(28):eaba1972
pubmed: 32832598
Int J Biochem Cell Biol. 2019 Nov;116:105598
pubmed: 31499176
Nat Genet. 1999 Jan;21(1):138-41
pubmed: 9916808
Am J Physiol Lung Cell Mol Physiol. 2019 Dec 1;317(6):L823-L831
pubmed: 31553626
Annu Rev Pathol. 2014;9:157-79
pubmed: 24050627
Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):822-6
pubmed: 9517597
Int J Environ Res Public Health. 2009 Jan;6(1):209-24
pubmed: 19440278
Mech Dev. 2001 Nov;109(1):13-26
pubmed: 11677049
Eur Respir Rev. 2020 Nov 18;29(158):
pubmed: 33208482
Cell. 2007 Jun 29;129(7):1377-88
pubmed: 17604725
J Clin Invest. 2009 Jun;119(6):1429-37
pubmed: 19487819
Adv Exp Med Biol. 2019;1084:187-206
pubmed: 31175638
N Engl J Med. 2019 Sep 26;381(13):1257-1266
pubmed: 31553837
Dev Dyn. 2016 Mar;245(3):307-22
pubmed: 26638186
Nat Genet. 1998 Sep;20(1):58-61
pubmed: 9731532
Sci Signal. 2020 Mar 03;13(621):
pubmed: 32127497
Development. 1995 Apr;121(4):1015-22
pubmed: 7538066
Dev Biol. 2003 Jun 1;258(1):185-200
pubmed: 12781692
Dev Cell. 2017 Oct 9;43(1):48-59.e5
pubmed: 29017029
Eur Respir J. 2012 Feb;39(2):419-28
pubmed: 21778164
Development. 2000 Jun;127(12):2695-704
pubmed: 10821767
Clin Exp Allergy. 2020 Feb;50(2):135-146
pubmed: 31746062
PLoS One. 2015 Mar 23;10(3):e0122446
pubmed: 25798916
Curr Biol. 1998 Sep 24;8(19):1083-6
pubmed: 9768363
Kidney Int. 2011 May;79(9):944-56
pubmed: 21307839
Development. 2007 Aug;134(16):2969-79
pubmed: 17634193
Development. 2006 May;133(9):1611-24
pubmed: 16613830
Development. 2006 Apr;133(8):1507-17
pubmed: 16540513
Cell. 2017 Sep 7;170(6):1134-1148.e10
pubmed: 28886382
Cold Spring Harb Perspect Biol. 2017 Apr 3;9(4):
pubmed: 27864314
Expert Rev Respir Med. 2018 Feb;12(2):83-85
pubmed: 29278018
Int J Chron Obstruct Pulmon Dis. 2015 Sep 14;10:1935-49
pubmed: 26392769
Development. 2003 Jul;130(13):3063-74
pubmed: 12756187
Pediatr Res. 2005 May;57(5 Pt 2):26R-37R
pubmed: 15817505
Clin Exp Allergy. 2016 Apr;46(4):529-42
pubmed: 27021118
Development. 1994 Oct;120(10):2749-71
pubmed: 7607068
PLoS Genet. 2006 Jul;2(7):e119
pubmed: 16895450
Am J Respir Crit Care Med. 2018 Oct 1;198(7):961-964
pubmed: 29757681
Dev Biol. 1992 Jan;149(1):123-33
pubmed: 1728582
Front Physiol. 2014 Aug 01;5:284
pubmed: 25136318
Respirology. 2010 Aug;15(6):930-8
pubmed: 20630030
N Engl J Med. 2016 Sep 1;375(9):871-8
pubmed: 27579637
Dev Biol. 1997 Jun 15;186(2):224-36
pubmed: 9205141
Semin Respir Crit Care Med. 2008 Dec;29(6):651-61
pubmed: 19221963
Cell. 2009 Nov 25;139(5):871-90
pubmed: 19945376
Am J Respir Crit Care Med. 1998 Dec;158(6):1951-7
pubmed: 9847291
Stem Cell Res Ther. 2019 Dec 2;10(1):366
pubmed: 31791401
FASEB J. 1992 Aug;6(11):2895-904
pubmed: 1644255
PLoS One. 2012;7(6):e39736
pubmed: 22768115
J Cell Biol. 2006 Mar 27;172(7):973-81
pubmed: 16567498
N Engl J Med. 2015 Jul 9;373(2):111-22
pubmed: 26154786
Am J Respir Cell Mol Biol. 2000 Jul;23(1):3-6
pubmed: 10873146
Dev Biol. 1998 Sep 15;201(2):125-34
pubmed: 9740653
Nat Genet. 1995 Dec;11(4):415-21
pubmed: 7493022
Dev Biol. 1993 Oct;159(2):462-73
pubmed: 8405671
Cell Commun Signal. 2018 Mar 20;16(1):11
pubmed: 29558958
Respir Res. 2019 Mar 4;20(1):49
pubmed: 30832670
PLoS Comput Biol. 2012;8(2):e1002377
pubmed: 22359491
Br Med J. 1977 Jun 25;1(6077):1645-8
pubmed: 871704
Development. 2017 Dec 1;144(23):4328-4335
pubmed: 29084801
Am J Physiol Lung Cell Mol Physiol. 2001 May;280(5):L1030-9
pubmed: 11290528
Curr Top Dev Biol. 2010;90:73-158
pubmed: 20691848
PLoS One. 2009 Dec 16;4(12):e8157
pubmed: 20016779
Thorax. 2004 Apr;59(4):308-12
pubmed: 15047950
J Clin Invest. 2003 Dec;112(12):1776-84
pubmed: 14679171
Thorax. 2018 Jun;73(6):565-574
pubmed: 29653970
PLoS One. 2011;6(9):e25450
pubmed: 21980461
Nature. 2021 May;593(7860):575-579
pubmed: 33981032
Cell. 2001 Mar 23;104(6):875-89
pubmed: 11290325
Cell Stem Cell. 2017 Aug 3;21(2):166-177
pubmed: 28777943
J Clin Invest. 2007 Nov;117(11):3551-62
pubmed: 17965775
Front Physiol. 2015 Dec 02;6:346
pubmed: 26696894
Int J Chron Obstruct Pulmon Dis. 2015 Aug 04;10:1515-24
pubmed: 26346976
Commun Biol. 2018 Oct 16;1:170
pubmed: 30345394
Dev Biol. 2008 Aug 15;320(2):340-50
pubmed: 18602626
Nature. 2013 Nov 14;503(7475):218-23
pubmed: 24196716
Genes Dev. 1998 Oct 15;12(20):3156-61
pubmed: 9784490
Annu Rev Physiol. 2004;66:625-45
pubmed: 14977416
Nat Commun. 2021 May 4;12(1):2509
pubmed: 33947861
Respir Res. 2014 Oct 03;15:118
pubmed: 25272959
Development. 1996 Jun;122(6):1693-702
pubmed: 8674409
Respir Res. 2011 Oct 05;12:130
pubmed: 21970519
J Thorac Dis. 2016 Jan;8(1):E31-40
pubmed: 26904251
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16626-30
pubmed: 18922767
Nat Rev Mol Cell Biol. 2020 Jun;21(6):341-352
pubmed: 32300252
Respir Med. 2015 Nov;109(11):1371-80
pubmed: 26342840
Development. 2014 Feb;141(3):502-13
pubmed: 24449833
J Biol Chem. 2005 Feb 11;280(6):4834-41
pubmed: 15556938
Nature. 2013 Aug 29;500(7464):589-92
pubmed: 23873040
Dev Cell. 2014 Jul 28;30(2):137-50
pubmed: 25043473
Regen Med. 2006 Jul;1(4):497-509
pubmed: 17465844
Development. 1997 Dec;124(23):4867-78
pubmed: 9428423
Eur Respir J. 2012 Dec;40(6):1362-73
pubmed: 22496324
PLoS One. 2015 Jul 06;10(7):e0132015
pubmed: 26147967
Nat Genet. 2011 Sep 25;43(11):1082-90
pubmed: 21946350
Genes Dev. 2016 Jan 1;30(1):1-17
pubmed: 26728553
J Cell Sci. 2006 Jun 1;119(Pt 11):2204-13
pubmed: 16684817
Cell. 2016 Jun 30;166(1):21-45
pubmed: 27368099
Annu Rev Cell Dev Biol. 2012;28:687-717
pubmed: 22804578
Development. 2021 Dec 15;148(24):
pubmed: 34927678
Lancet. 2004 Aug 21-27;364(9435):709-21
pubmed: 15325838
Eur J Histochem. 2012 Jun 29;56(3):e29
pubmed: 23027345
PLoS Genet. 2009 Mar;5(3):e1000429
pubmed: 19300500
Am J Respir Crit Care Med. 2019 Jun 15;199(12):1517-1536
pubmed: 30554520
Development. 2011 Aug;138(15):3169-77
pubmed: 21750028
Int J Mol Sci. 2018 Aug 20;19(8):
pubmed: 30127261
Dev Dyn. 2005 Jul;233(3):706-20
pubmed: 15937929
Am J Physiol Renal Physiol. 2008 Mar;294(3):F542-53
pubmed: 18172001
Dev Cell. 2014 Jul 28;30(2):151-65
pubmed: 25043474
Cell. 2017 Sep 7;170(6):1149-1163.e12
pubmed: 28886383