A Pleiotropic Role of the Hepatitis B Virus Core Protein in Hepatocarcinogenesis.
Carcinoma, Hepatocellular
/ genetics
Cell Movement
Cell Proliferation
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Hepatitis B virus
/ metabolism
Hepatitis B, Chronic
/ complications
Humans
Liver Neoplasms
/ genetics
Promoter Regions, Genetic
Viral Core Proteins
/ metabolism
Virus Replication
hepatitis B virus
hepatitis B virus core protein
hepatocarcinogenesis
hepatocellular carcinoma
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Dec 2021
20 Dec 2021
Historique:
received:
25
11
2021
revised:
18
12
2021
accepted:
19
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
29
1
2022
Statut:
epublish
Résumé
Chronic hepatitis B virus (HBV) infection is one of the most common factors associated with hepatocellular carcinoma (HCC), which is the sixth most prevalent cancer among all cancers worldwide. However, the pathogenesis of HBV-mediated hepatocarcinogenesis is unclear. Evidence currently available suggests that the HBV core protein (HBc) plays a potential role in the development of HCC, such as the HBV X protein. The core protein, which is the structural component of the viral nucleocapsid, contributes to almost every stage of the HBV life cycle and occupies diverse roles in HBV replication and pathogenesis. Recent studies have shown that HBc was able to disrupt various pathways involved in liver carcinogenesis: the signaling pathways implicated in migration and proliferation of hepatoma cells, apoptosis pathways, and cell metabolic pathways inducing the development of HCC; and the immune system, through the expression and production of proinflammatory cytokines. In addition, HBc can modulate normal functions of hepatocytes through disrupting human host gene expression by binding to promoter regions. This HBV protein also promotes HCC metastasis through epigenetic alterations, such as micro-RNA. This review focuses on the molecular pathogenesis of the HBc protein in HBV-induced HCC.
Identifiants
pubmed: 34948447
pii: ijms222413651
doi: 10.3390/ijms222413651
pmc: PMC8707456
pii:
doi:
Substances chimiques
Viral Core Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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