Opioid Analgesic Prescription in French Children: A National Population-Based Study.
analgesics
codeine
morphine
pain
pediatrics
tramadol
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
17 12 2021
17 12 2021
Historique:
received:
10
11
2021
revised:
14
12
2021
accepted:
15
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
31
12
2021
Statut:
epublish
Résumé
Codeine use was restricted in 2013 and is currently contraindicated for children below the age of 12 years. We examined how the prescription of opioid analgesics in children in France evolved between 2012 and 2018. Our population-based study from the SNIIRAM database (National System of Health Insurance Inter-Regime Information) was designed to determine trends in opioid prescription from 2012 to 2018 in all French children. The number of children who received at least one opioid prescription gradually declined from 452,665 in 2012 (347.5 children per 10,000) to 169,338 in 2018 (130.3 children per 10,000). This decrease was especially marked for codeine (36 children per 10,000 in 2018 vs. 308.5 children per 10,000 in 2012), whereas the number of tramadol prescriptions increased by 171% in 2018 (94.6 children per 10,000). Despite the increase, strong opioids still formed only a small proportion of prescriptions (2.6 children per 10,000 given opioids in 2018). Overall opioid prescriptions in French children dramatically decreased between 2012 and 2018, probably owing to restrictions on the use of codeine. Codeine has been partly replaced by tramadol. Morphine is still probably underused. This suggests that opioids are being used less often for pain management in children.
Identifiants
pubmed: 34948923
pii: ijerph182413316
doi: 10.3390/ijerph182413316
pmc: PMC8702064
pii:
doi:
Substances chimiques
Analgesics, Opioid
0
Tramadol
39J1LGJ30J
Morphine
76I7G6D29C
Codeine
UX6OWY2V7J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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