Evaluating micellar liquid chromatographic methods on octadecyl particle-based and monolithic columns to predict the skin permeation of drug and cosmetic molecules.
Micellar liquid chromatography
Monolithic column
Quantitative retention-activity relationship models
Quantitative structure-activity relationship models
Skin permeability
Journal
Journal of chromatography. A
ISSN: 1873-3778
Titre abrégé: J Chromatogr A
Pays: Netherlands
ID NLM: 9318488
Informations de publication
Date de publication:
25 Jan 2022
25 Jan 2022
Historique:
received:
29
10
2021
revised:
12
12
2021
accepted:
14
12
2021
pubmed:
27
12
2021
medline:
19
1
2022
entrez:
26
12
2021
Statut:
ppublish
Résumé
A micellar liquid chromatographic method was developed to assist in the modeling of the skin permeability of pharmaceutical and cosmetic compounds. The composition of the mobile phase was determined by means of a two-factor central composite design, after which it was tested on both a particle-based and monolithic column. The latter provided the opportunity to increase the flow rate from 1 to 8 mL/min without reaching too high backpressures. The micellar conditions allowed analyzing a large test set of compounds with diverse characteristics with just one mobile-phase composition. The obtained experimental chromatographic descriptors besides two sets of theoretical molecular descriptors were used to model the skin permeability coefficient log K
Identifiants
pubmed: 34954537
pii: S0021-9673(21)00875-X
doi: 10.1016/j.chroma.2021.462753
pii:
doi:
Substances chimiques
Cosmetics
0
Micelles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
462753Informations de copyright
Copyright © 2021. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no conflict of interest.