The light response in chickens divergently selected for feather pecking behavior reveals mechanistic insights towards psychiatric disorders.
Animals
Behavior, Animal
/ physiology
Brain
/ metabolism
Chickens
/ metabolism
DEAD-box RNA Helicases
/ genetics
Disease Models, Animal
Feathers
/ metabolism
Gene Expression
/ genetics
Light
Mental Disorders
/ genetics
Obsessive Behavior
/ genetics
Ribonuclease III
/ genetics
Transcriptome
/ genetics
Feather pecking
GABA
Genome-wide association study
Schizophrenia
Transcriptomics
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
08
10
2021
accepted:
17
12
2021
pubmed:
27
12
2021
medline:
29
3
2022
entrez:
26
12
2021
Statut:
ppublish
Résumé
Feather pecking is a serious behavioral disorder in chickens that has a considerable impact on animal welfare and poses an economic burden for poultry farming. To study the underlying genetics of feather pecking animals were divergently selected for feather pecking over 15 generations based on estimated breeding values for the behavior. By characterizing the transcriptomes of whole brains isolated from high and low feather pecking chickens in response to light stimulation we discovered a putative dysregulation of micro RNA processing caused by a lack of Dicer1. This results in a prominent downregulation of the GABRB2 gene and other GABA receptor transcripts, which might cause a constant high level of excitation in the brains of high feather pecking chickens. Moreover, our results point towards an increase in immune system-related transcripts that may be caused by higher interferon concentrations due to Dicer1 downregulation. Based on our results, we conclude that feather pecking in chickens and schizophrenia in humans have numerous common features. For instance, a Dicer1 dependent disruption of miRNA biogenesis and the lack of GABRB2 expression have been linked to schizophrenia pathogenesis. Furthermore, disturbed circadian rhythms and dysregulation of genes involved in the immune system are common features of both conditions.
Sections du résumé
BACKGROUND
BACKGROUND
Feather pecking is a serious behavioral disorder in chickens that has a considerable impact on animal welfare and poses an economic burden for poultry farming. To study the underlying genetics of feather pecking animals were divergently selected for feather pecking over 15 generations based on estimated breeding values for the behavior.
METHODS AND RESULTS
RESULTS
By characterizing the transcriptomes of whole brains isolated from high and low feather pecking chickens in response to light stimulation we discovered a putative dysregulation of micro RNA processing caused by a lack of Dicer1. This results in a prominent downregulation of the GABRB2 gene and other GABA receptor transcripts, which might cause a constant high level of excitation in the brains of high feather pecking chickens. Moreover, our results point towards an increase in immune system-related transcripts that may be caused by higher interferon concentrations due to Dicer1 downregulation.
CONCLUSION
CONCLUSIONS
Based on our results, we conclude that feather pecking in chickens and schizophrenia in humans have numerous common features. For instance, a Dicer1 dependent disruption of miRNA biogenesis and the lack of GABRB2 expression have been linked to schizophrenia pathogenesis. Furthermore, disturbed circadian rhythms and dysregulation of genes involved in the immune system are common features of both conditions.
Identifiants
pubmed: 34954808
doi: 10.1007/s11033-021-07111-4
pii: 10.1007/s11033-021-07111-4
pmc: PMC8825407
doi:
Substances chimiques
Ribonuclease III
EC 3.1.26.3
DEAD-box RNA Helicases
EC 3.6.4.13
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1649-1654Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : TE622/4-2
Organisme : Deutsche Forschungsgemeinschaft
ID : BE3703/8-2
Informations de copyright
© 2021. The Author(s).
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