Ciprofloxacin exposure and adverse pregnancy outcomes: A Danish nationwide cohort study.
ciprofloxacin
early exposure
major malformation
miscarriage
Journal
BJOG : an international journal of obstetrics and gynaecology
ISSN: 1471-0528
Titre abrégé: BJOG
Pays: England
ID NLM: 100935741
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
revised:
26
11
2021
received:
26
09
2021
accepted:
06
12
2021
pubmed:
27
12
2021
medline:
14
7
2022
entrez:
26
12
2021
Statut:
ppublish
Résumé
To examine the association between maternal exposure to ciprofloxacin and the risk of miscarriage and major malformations. A nationwide register-based cohort study. Data were obtained from the Medical Birth Registry, the National Hospital Registry, the Danish National Prescription Registry and Statistics Denmark. Data were collected in the period between 1997 and 2016 and included all registered pregnancies that ended in an elective termination, miscarriage, stillbirth or a live birth. Exposure was defined as redeeming one or more prescriptions of ciprofloxacin. Miscarriage was defined as a diagnosis given before 22 weeks without any medical intervention. Major malformations were classified according to EUROCAT 1.4. We matched ciprofloxacin-exposed pregnancies to unexposed pregnancies on the propensity score in a ratio 1:4. To estimate the hazard ratio (HR) of miscarriage a Cox proportional hazard regression model was used. A log binomial model was used to estimate the relative risk ratio (RR) of major malformations. HR of miscarriage and the RR of major malformations. A total of 1 650 649 pregnancies were identified. Of these, 10 250 (2050 ciprofloxacin-exposed) and 6100 (1220 ciprofloxacin-exposed) were included in the miscarriage and major malformation analysis, respectively. The HR of miscarriage was 0.99 (95% confidence interval [CI] 0.84-1.17). For major malformation, the RR was 1.01 (95% CI 0.72-1.40). For the organ-specific major malformations and the sensitivity analyses, no significant increased risks were identified. We demonstrated no association between miscarriage and maternal ciprofloxacin exposure within the first 22 weeks of pregnancy, or between major malformations and maternal exposure during the first trimester. No association between maternal ciprofloxacin exposure and adverse pregnancy outcomes.
Identifiants
pubmed: 34954900
doi: 10.1111/1471-0528.17083
pmc: PMC9544954
doi:
Substances chimiques
Ciprofloxacin
5E8K9I0O4U
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1503-1511Subventions
Organisme : P.Carl Petersens Fond
ID : 19133
Informations de copyright
© 2021 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.
Références
Birth Defects Res A Clin Mol Teratol. 2012 Mar;94(3):153-61
pubmed: 22253196
Lancet. 1995 Jul 29;346(8970):307-8
pubmed: 7630260
Scand J Public Health. 2003;31(1):12-6
pubmed: 12623519
Am J Obstet Gynecol. 2021 Dec;225(6):670.e1-670.e9
pubmed: 34058171
medRxiv. 2020 Nov 04;:
pubmed: 33173887
Clin Epidemiol. 2010 Oct 27;2:247-50
pubmed: 21152251
Scand J Public Health. 2011 Jul;39(7 Suppl):103-5
pubmed: 21775365
BJOG. 2018 Aug;125(9):1069-1076
pubmed: 29319210
Antimicrob Agents Chemother. 1998 Jun;42(6):1336-9
pubmed: 9624471
Scand J Public Health. 2011 Jul;39(7 Suppl):38-41
pubmed: 21775349
CMAJ. 2017 May 1;189(17):E625-E633
pubmed: 28461374
J Am Heart Assoc. 2019 Mar 19;8(6):e011615
pubmed: 30857459
Antimicrob Agents Chemother. 2014 Aug;58(8):4392-8
pubmed: 24841264
Arch Pediatr Adolesc Med. 2009 Nov;163(11):978-85
pubmed: 19884587
Br J Clin Pharmacol. 2017 Nov;83(11):2557-2571
pubmed: 28722171
Br J Clin Pharmacol. 1996 Apr;41(4):277-84
pubmed: 8730972
Paediatr Perinat Epidemiol. 2009 Jan;23(1):18-28
pubmed: 19228311
Int J Antimicrob Agents. 2005 Oct;26(4):323-6
pubmed: 16144758
BJOG. 2022 Aug;129(9):1503-1511
pubmed: 34954900
Eur J Epidemiol. 2018 Jan;33(1):27-36
pubmed: 29349587
Eur J Obstet Gynecol Reprod Biol. 2005 Sep 1;122(1):61-5
pubmed: 16154040
Ann Pharmacother. 2019 Jun;53(6):639-651
pubmed: 30556401
Clin Epidemiol. 2015 Nov 17;7:449-90
pubmed: 26604824
Eur J Epidemiol. 2014 Aug;29(8):541-9
pubmed: 24965263
PLoS Med. 2016 Sep 12;13(9):e1002130
pubmed: 27618631
Multivariate Behav Res. 2011 May;46(3):399-424
pubmed: 21818162
Scand J Public Health. 2011 Jul;39(7 Suppl):91-4
pubmed: 21775362