Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A Case.

Adult COVID-19 / complications Humans Male Myocarditis / immunology RNA, Viral / analysis SARS-CoV-2 Systemic Inflammatory Response Syndrome / immunology T-Lymphocytes / immunology
CDR3 sequences MIS-A SARS-CoV-2 SARS-CoV-2 epitopes T cell receptor (TCR) cd-hit myocarditis

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2021
Historique:
received: 17 09 2021
accepted: 23 11 2021
entrez: 27 12 2021
pubmed: 28 12 2021
medline: 7 1 2022
Statut: epublish

Résumé

A 26-year-old otherwise healthy man died of fulminant myocarditis. Nasopharyngeal specimens collected premortem tested negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathological evaluation of the heart showed myocardial necrosis surrounded by cytotoxic T-cells and tissue-repair macrophages. Myocardial T-cell receptor (TCR) sequencing revealed hyper-dominant clones with highly similar sequences to TCRs that are specific for SARS-CoV-2 epitopes. SARS-CoV-2 RNA was detected in the gut, supporting a diagnosis of multisystem inflammatory syndrome in adults (MIS-A). Molecular targets of MIS-associated inflammation are not known. Our data indicate that SARS-CoV-2 antigens selected high-frequency T-cell clones that mediated fatal myocarditis.

Identifiants

DOI: 10.3389/fimmu.2021.779026 PMID: 34956207 PMC: PMC8695925
pubmed: 34956207
doi: 10.3389/fimmu.2021.779026
pmc: PMC8695925
doi:

Substances chimiques

RNA, Viral 0

Types de publication

Case Reports Journal Article Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

779026

Informations de copyright

Copyright © 2021 Vannella, Oguz, Stein, Pittaluga, Dikoglu, Kanwal, Ramelli, Briese, Su, Wu, Ramos-Benitez, Perez-Valencia, Babyak, Cha, Chung, Ylaya, Madathil, Saharia, Scalea, Tran, Herr, Kleiner, Hewitt, Notarangelo, Grazioli and Chertow.

Déclaration de conflit d'intérêts

Authors CO, LS and XW were employed by company Leidos Biomedical Research, Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Bioinformatics. 2012 Dec 1;28(23):3150-2
pubmed: 23060610
Rheumatol Int. 2021 May;41(5):993-1008
pubmed: 33742229
Mol Med Rep. 2014 Dec;10(6):2811-8
pubmed: 25241846
Circ Res. 2017 Sep 15;121(7):731-748
pubmed: 28912180
J Clin Invest. 2021 Jul 15;131(14):
pubmed: 34032635
Science. 2019 Nov 15;366(6467):881-886
pubmed: 31727837
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
mBio. 2015 Sep 22;6(5):e01491-15
pubmed: 26396248
Cell Rep Med. 2021 Feb 16;2(2):100204
pubmed: 33521695
Br J Haematol. 2014 Sep;166(5):729-38
pubmed: 24931452
Nat Med. 2000 Jun;6(6):693-7
pubmed: 10835688
Pathol Res Pract. 2020 Nov;216(11):153195
pubmed: 32890939
Nature. 2017 Jul 6;547(7661):94-98
pubmed: 28636589
Nat Commun. 2013;4:2680
pubmed: 24157944
J Clin Invest. 2020 Dec 1;130(12):6194-6197
pubmed: 33108354
MMWR Morb Mortal Wkly Rep. 2020 Oct 09;69(40):1450-1456
pubmed: 33031361
Nat Med. 2020 Dec;26(12):1819-1824
pubmed: 33139949
F1000Prime Rep. 2014 May 06;6:25
pubmed: 24904749
Bioinformatics. 2011 Mar 15;27(6):863-4
pubmed: 21278185
Nature. 2017 Jul 6;547(7661):89-93
pubmed: 28636592
MMWR Morb Mortal Wkly Rep. 2020 Aug 14;69(32):1074-1080
pubmed: 32790663
Nat Med. 2000 Jun;6(6):631-2
pubmed: 10835674
Nat Med. 2021 May;27(5):892-903
pubmed: 33767405
Chest. 2021 Feb;159(2):471-472
pubmed: 33285106

Auteurs

Kevin M Vannella (KM)

Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

Cihan Oguz (C)

National Institute of Allergy and Infectious Diseases Collaborative Bioinformatics Resource, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States.
Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States.

Sydney R Stein (SR)

Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

Stefania Pittaluga (S)

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Esra Dikoglu (E)

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Arjun Kanwal (A)

Division of Cardiology, Westchester Medical Center, Valhalla, NY, United States.

Sabrina C Ramelli (SC)

Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States.

Thomas Briese (T)

Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, NY, United States.

Ling Su (L)

Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States.

Xiaolin Wu (X)

Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States.

Marcos J Ramos-Benitez (MJ)

Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Postdoctoral Research Associate Training Program, National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD, United States.

Luis J Perez-Valencia (LJ)

Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

Ashley Babyak (A)

Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

Nu Ri Cha (NR)

Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, United States.

Joon-Yong Chung (JY)

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Kris Ylaya (K)

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Ronson J Madathil (RJ)

Department of Surgery, Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD, United States.

Kapil K Saharia (KK)

Department of Medicine, Division of Infectious Disease, University of Maryland School of Medicine, Baltimore, MD, United States.

Thomas M Scalea (TM)

Department of Surgery, Program in Trauma, R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, United States.

Quincy K Tran (QK)

Department of Emergency Medicine, R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, United States.

Daniel L Herr (DL)

Department of Medicine, Program in Trauma, R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, United States.

David E Kleiner (DE)

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Stephen M Hewitt (SM)

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Luigi D Notarangelo (LD)

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

Alison Grazioli (A)

Kidney Diseases Branch, Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.

Daniel S Chertow (DS)

Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Evidence of SARS-CoV-2-Specific...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Evidence of SARS-CoV-2-Specific...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Evidence of SARS-CoV-2-Specific...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Cardiomyopathies › Myocardite › Evidence of SARS-CoV-2-Specific...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN viral › Evidence of SARS-CoV-2-Specific...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Evidence of SARS-CoV-2-Specific...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Choc › Syndrome de réponse inflammatoire généralisée › Evidence of SARS-CoV-2-Specific...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Evidence of SARS-CoV-2-Specific...