Circadian Influences on Chemotherapy Efficacy in a Mouse Model of Brain Metastases of Breast Cancer.

blood-brain barrier brain metastases breast cancer chronotherapeutic circadian rhythm

Journal

Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867

Informations de publication

Date de publication:
2021
Historique:
received: 03 08 2021
accepted: 19 11 2021
entrez: 27 12 2021
pubmed: 28 12 2021
medline: 28 12 2021
Statut: epublish

Résumé

Chemotherapy is more effective in the treatment of peripheral tumors than brain metastases, likely reflecting the reduced ability of chemotherapy to cross the blood-brain barrier (BBB) and blood-tumor barrier at efficacious concentrations. Recent studies demonstrate circadian regulation of the BBB. Thus, we predicted that optimally timed chemotherapy would increase anti-tumor efficacy in a model of brain metastases of breast cancer (BMBC). First, we characterized novel daily alterations in BBB permeability to a commonly used chemotherapeutic,

Identifiants

pubmed: 34956876
doi: 10.3389/fonc.2021.752331
pmc: PMC8695439
doi:

Types de publication

Journal Article

Langues

eng

Pagination

752331

Subventions

Organisme : NCI NIH HHS
ID : K00 CA253768
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM121322
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG052375
Pays : United States

Informations de copyright

Copyright © 2021 Walker, Sprowls, Bumgarner, Liu, Meléndez-Fernández, Walton, Lockman, DeVries and Nelson.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

William H Walker (WH)

Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States.

Samuel A Sprowls (SA)

Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, United States.

Jacob R Bumgarner (JR)

Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States.

Jennifer A Liu (JA)

Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States.

O Hecmarie Meléndez-Fernández (OH)

Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States.

James C Walton (JC)

Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States.

Paul R Lockman (PR)

Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States.
Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, United States.
WVU Cancer Institute, West Virginia University, Morgantown, WV, United States.

A Courtney DeVries (AC)

Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States.
WVU Cancer Institute, West Virginia University, Morgantown, WV, United States.
Department of Medicine, Division of Oncology/Hematology, West Virginia University, Morgantown, WV, United States.

Randy J Nelson (RJ)

Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States.

Classifications MeSH