Racial differences in cardiopulmonary outcomes of hospitalized COVID-19 patients with acute kidney injury.
AKI
Black race
COVID-19
Cardiac events
Mortality
Journal
Reviews in cardiovascular medicine
ISSN: 1530-6550
Titre abrégé: Rev Cardiovasc Med
Pays: Singapore
ID NLM: 100960007
Informations de publication
Date de publication:
22 12 2021
22 12 2021
Historique:
received:
08
08
2021
revised:
12
10
2021
accepted:
01
11
2021
entrez:
27
12
2021
pubmed:
28
12
2021
medline:
31
12
2021
Statut:
ppublish
Résumé
In-hospital acute kidney injury (IH-AKI) has been reported in a significant proportion of patients with COVID-19 and is associated with increased disease burden and poor outcomes. However, the mechanisms of injury are not fully understood. We sought to determine the significance of race on cardiopulmonary outcomes and in-hospital mortality of hospitalized COVID-19 patients with AKI. We conducted a retrospective cohort study of consecutive patients hospitalized in Grady Health System in Atlanta, Georgia between February and July 2020, who tested positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on qualitative polymerase-chain-reaction assay. We evaluated the primary composite outcome of in-hospital cardiac events, and mortality in blacks with AKI versus non-blacks with AKI. In a subgroup analysis, we evaluated the impact of AKI in all blacks and in all non-blacks. Of 293 patients, effective sample size was 267 after all exclusion criteria were applied. The mean age was 61.4 ± 16.7, 39% were female, and 75 (28.1%) had IH-AKI. In multivariable analyses, blacks with IH-AKI were not more likely to have in-hospital cardiac events (aOR 0.3, 95% Confidence interval (CI) 0.04-1.86,
Identifiants
pubmed: 34957809
pii: S1530-6550(21)00259-3
doi: 10.31083/j.rcm2204174
pmc: PMC9054458
mid: NIHMS1800196
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1667-1675Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR002381
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002378
Pays : United States
Informations de copyright
© 2021 The Author(s). Published by IMR Press.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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