Epitope Mapping of an Anti-Human CCR9 Monoclonal Antibody (C
C9Mab-1
enzyme-linked immunosorbent assay
epitope mapping
human CCR9
monoclonal antibody
Journal
Monoclonal antibodies in immunodiagnosis and immunotherapy
ISSN: 2167-9436
Titre abrégé: Monoclon Antib Immunodiagn Immunother
Pays: United States
ID NLM: 101590955
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
entrez:
27
12
2021
pubmed:
28
12
2021
medline:
14
1
2022
Statut:
ppublish
Résumé
One of G protein-coupled receptors, CCR9, is mainly expressed in the thymocytes and the small bowel. The ligand of CCR9 is CCL25 (TECK), and the CCR9-CCL25 axis controls T cell maturation and intestinal immune response. CCR9 is related to graft-versus-host disease and autoimmune diseases. Recent studies have been reported that CCR9 is also associated with tumor proliferation, apoptosis, migration, and drug resistance. Therefore, CCR9-targeting therapy is receiving a lot of attention. Previously, we developed an anti-human CCR9 (hCCR9) monoclonal antibody, C
Identifiants
pubmed: 34958276
doi: 10.1089/mab.2021.0037
doi:
Substances chimiques
Antibodies, Monoclonal
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM