The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study.

Adolescent Cardiometabolic Risk Factors Child Child, Preschool Female Humans Insulin Resistance Male Nutritional Status Pediatric Obesity / metabolism Puberty / physiology Vitamin D / analogs & derivatives
cardiometabolic risk factors child insulin resistance obesity puberty vitamin D

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
15 Dec 2021
Historique:
received: 16 11 2021
revised: 07 12 2021
accepted: 10 12 2021
entrez: 28 12 2021
pubmed: 29 12 2021
medline: 14 1 2022
Statut: epublish

Résumé

Obesity and cardiometabolic risk have been associated with vitamin D levels even in children. The objective of the present study was to evaluate the association between insulin resistance (IR), cardiometabolic risk factors, and vitamin D in children from prepubertal to pubertal stages. A total of 76 children from the PUBMEP study, aged 4-12 years at baseline, were included. Children were evaluated in prepubertal and pubertal stages. Anthropometric measurements and selected cardiometabolic risk biomarkers, such as plasma glucose, blood lipids, insulin, adiponectin, leptin, and blood pressure, and serum 25-hydroxyvitamin D (25(OH)D) were determined. Children were categorized by obesity degree and IR status combined before and after puberty. Paired

Identifiants

DOI: 10.3390/nu13124488 PMID: 34960039 PMC: PMC8709093
pubmed: 34960039
pii: nu13124488
doi: 10.3390/nu13124488
pmc: PMC8709093
pii:
doi:

Substances chimiques

Vitamin D 1406-16-2
25-hydroxyvitamin D A288AR3C9H

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Instituto de Salud Carlos III
ID : PI11/01425, PI11/02042, PI11/02059, PI16/01301, PI16/01205, PI16/00871 and PI20/00563
Organisme : Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
ID : CB15/00131, CB15/00043

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Auteurs

Liliane Viana Pires (LV)

Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain.
Center of Biomedical Research, Institute of Nutrition and Food Technology "José Mataix", University of Granada, Avda. del Conocimiento s/n, 18016 Armilla, Spain.
Nutrition Sciences Post-Graduation Program, Department of Nutrition, Federal University of Sergipe, Saint Cristopher 49100-000, Brazil.
ORCID: 0000-0003-1710-0836

Esther M González-Gil (EM)

Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain.
Center of Biomedical Research, Institute of Nutrition and Food Technology "José Mataix", University of Granada, Avda. del Conocimiento s/n, 18016 Armilla, Spain.
Growth, Exercise, Nutrition and Development (GENUD) Research Group, University of Zaragoza, 50009 Zaragoza, Spain.

Augusto Anguita-Ruiz (A)

Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain.
Center of Biomedical Research, Institute of Nutrition and Food Technology "José Mataix", University of Granada, Avda. del Conocimiento s/n, 18016 Armilla, Spain.
CIBEROBN (Physiopathology of Obesity and Nutrition), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
ORCID: 0000-0001-6888-1041

Gloria Bueno (G)

Growth, Exercise, Nutrition and Development (GENUD) Research Group, University of Zaragoza, 50009 Zaragoza, Spain.
CIBEROBN (Physiopathology of Obesity and Nutrition), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Instituto Agroalimentario de Aragón (IA2) and Instituto de Investigación Sanitaria de Aragón (IIS Aragón), 50009 Zaragoza, Spain.

Mercedes Gil-Campos (M)

CIBEROBN (Physiopathology of Obesity and Nutrition), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Department of Pediatric Endocrinology, Institute Maimónides of Biomedicine Investigation of Córdoba (IMIBIC), Reina Sofia University Clinical Hospital, University of Córdoba, Avda. Menéndez Pidal s/n, 14004 Cordoba, Spain.
ORCID: 0000-0002-9007-0242

Rocío Vázquez-Cobela (R)

CIBEROBN (Physiopathology of Obesity and Nutrition), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Pediatric Department (USC), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), University Clinical Hospital, 15706 Santiago de Compostela, Spain.
ORCID: 0000-0002-3155-1601

Alexandra Pérez-Ferreirós (A)

Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Pediatric Department (USC), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), University Clinical Hospital, 15706 Santiago de Compostela, Spain.
ORCID: 0000-0002-7482-4374

Luis A Moreno (LA)

Growth, Exercise, Nutrition and Development (GENUD) Research Group, University of Zaragoza, 50009 Zaragoza, Spain.
CIBEROBN (Physiopathology of Obesity and Nutrition), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Instituto Agroalimentario de Aragón (IA2) and Instituto de Investigación Sanitaria de Aragón (IIS Aragón), 50009 Zaragoza, Spain.
ORCID: 0000-0003-0454-653X

Ángel Gil (Á)

Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain.
Center of Biomedical Research, Institute of Nutrition and Food Technology "José Mataix", University of Granada, Avda. del Conocimiento s/n, 18016 Armilla, Spain.
CIBEROBN (Physiopathology of Obesity and Nutrition), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Instituto de Investigación Biosanitaria ibs., 18012 Granada, Spain.
ORCID: 0000-0001-7663-0939

Rosaura Leis (R)

CIBEROBN (Physiopathology of Obesity and Nutrition), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Instituto de Investigación Biosanitaria ibs., 18012 Granada, Spain.
ORCID: 0000-0002-0540-4210

Concepción M Aguilera (CM)

Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain.
Center of Biomedical Research, Institute of Nutrition and Food Technology "José Mataix", University of Granada, Avda. del Conocimiento s/n, 18016 Armilla, Spain.
CIBEROBN (Physiopathology of Obesity and Nutrition), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
Department of Pediatric Endocrinology, Institute Maimónides of Biomedicine Investigation of Córdoba (IMIBIC), Reina Sofia University Clinical Hospital, University of Córdoba, Avda. Menéndez Pidal s/n, 14004 Cordoba, Spain.
ORCID: 0000-0002-1451-4788

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › The Vitamin D Decrease in Children with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Facteurs de risque de maladie cardiaque › Facteurs de risque cardiométabolique › The Vitamin D Decrease in Children with...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › The Vitamin D Decrease in Children with...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › The Vitamin D Decrease in Children with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Vitamin D Decrease in Children with...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › The Vitamin D Decrease in Children with...
questionsmedicales.fr › Caractéristiques de la population › État nutritionnel › The Vitamin D Decrease in Children with...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Obésité pédiatrique › The Vitamin D Decrease in Children with...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Puberté › The Vitamin D Decrease in Children with...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Sécostéroïdes › Vitamine D › The Vitamin D Decrease in Children with...