Corticosterone and Glucocorticoid Receptor in the Cortex of Rats during Aging-The Effects of Long-Term Food Restriction.
11-beta-Hydroxysteroid Dehydrogenase Type 1
/ genetics
Aging
/ physiology
Animals
Cerebral Cortex
/ metabolism
Corticosterone
/ metabolism
Cyclin-Dependent Kinase 5
/ genetics
Food Deprivation
Gene Expression Regulation
Glial Fibrillary Acidic Protein
/ genetics
HSP90 Heat-Shock Proteins
/ genetics
Male
NF-kappa B
/ genetics
Neuroprotection
Proto-Oncogene Proteins c-fos
/ genetics
RNA, Messenger
/ genetics
Random Allocation
Rats
Rats, Wistar
Receptors, Glucocorticoid
/ metabolism
Tacrolimus Binding Proteins
/ genetics
Time Factors
bcl-2-Associated X Protein
/ genetics
11β-HSD1
GRα isoforms
c-fos
food restriction
glucocorticoids
intermittent fasting
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
17 Dec 2021
17 Dec 2021
Historique:
received:
19
11
2021
revised:
09
12
2021
accepted:
10
12
2021
entrez:
28
12
2021
pubmed:
29
12
2021
medline:
15
1
2022
Statut:
epublish
Résumé
Numerous beneficial effects of food restriction on aging and age-related pathologies are well documented. It is also well-established that both short- and long-term food restriction regimens induce elevated circulating levels of glucocorticoids, stress-induced hormones produced by adrenal glands that can also exert deleterious effects on the brain. In the present study, we examined the effect of long-term food restriction on the glucocorticoid hormone/glucocorticoid receptor (GR) system in the cortex during aging, in 18- and 24-month-old rats. Corticosterone level was increased in the cortex of aged ad libitum-fed rats. Food restriction induced its further increase, accompanied with an increase in the level of 11β-hydroxysteroid dehydrogenase type 1. However, alterations in the level of GR phosphorylated at Ser
Identifiants
pubmed: 34960078
pii: nu13124526
doi: 10.3390/nu13124526
pmc: PMC8703853
pii:
doi:
Substances chimiques
GFAP protein, rat
0
Glial Fibrillary Acidic Protein
0
HSP90 Heat-Shock Proteins
0
NF-kappa B
0
Proto-Oncogene Proteins c-fos
0
RNA, Messenger
0
Receptors, Glucocorticoid
0
bcl-2-Associated X Protein
0
11-beta-Hydroxysteroid Dehydrogenase Type 1
EC 1.1.1.146
Cyclin-Dependent Kinase 5
EC 2.7.11.1
Cdk5 protein, rat
EC 2.7.11.22
Tacrolimus Binding Proteins
EC 5.2.1.-
tacrolimus binding protein 5
EC 5.2.1.8
Corticosterone
W980KJ009P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education, Science and Technological Development of the Republic of Serbia
ID : 451-03-9/2021-14/200007
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