A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD

Animals Behavior, Animal Fatty Acids, Unsaturated / metabolism Glucagon-Like Peptide 1 / metabolism Hippocampus / pathology Liraglutide / pharmacology Male Mice Mice, Inbred C57BL Mice, Knockout Microglia / pathology Neurodegenerative Diseases / genetics Neuroinflammatory Diseases / genetics Prostaglandin D2 / biosynthesis Receptors, G-Protein-Coupled / genetics Suppression, Genetic / genetics
G-protein-coupled receptor 120 (GPR120) Neuroinflammation Prostaglandin

Journal

Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974

Informations de publication

Date de publication:
27 Dec 2021
Historique:
received: 24 06 2021
accepted: 16 12 2021
entrez: 28 12 2021
pubmed: 29 12 2021
medline: 29 3 2022
Statut: epublish

Résumé

Neuroinflammation is a key pathological component of neurodegenerative disease and is characterized by microglial activation and the secretion of proinflammatory mediators. We previously reported that a surge in prostaglandin D To reveal the relationship between PGD In the current study, we discovered notable neuroinflammation (increased PGD Our results suggest that neurological phenotypes in GPR120 KO mice are probably caused by dysfunction of intestinal GPR120. These observations raise the possibility that intestinal GLP-1 secretion, stimulated by intestinal GPR120, may remotely contributed to suppress PGD

Sections du résumé

BACKGROUND BACKGROUND
Neuroinflammation is a key pathological component of neurodegenerative disease and is characterized by microglial activation and the secretion of proinflammatory mediators. We previously reported that a surge in prostaglandin D
METHODS METHODS
To reveal the relationship between PGD
RESULTS RESULTS
In the current study, we discovered notable neuroinflammation (increased PGD
CONCLUSIONS CONCLUSIONS
Our results suggest that neurological phenotypes in GPR120 KO mice are probably caused by dysfunction of intestinal GPR120. These observations raise the possibility that intestinal GLP-1 secretion, stimulated by intestinal GPR120, may remotely contributed to suppress PGD

Identifiants

DOI: 10.1186/s12974-021-02361-2 PMID: 34961526 PMC: PMC8711188
pubmed: 34961526
doi: 10.1186/s12974-021-02361-2
pii: 10.1186/s12974-021-02361-2
pmc: PMC8711188
doi:

Substances chimiques

FFAR4 protein, mouse 0
Fatty Acids, Unsaturated 0
Receptors, G-Protein-Coupled 0
Liraglutide 839I73S42A
Glucagon-Like Peptide 1 89750-14-1
Prostaglandin D2 RXY07S6CZ2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

304

Subventions

Organisme : ministry of education, culture, sports, science and technology
ID : 18K06899
Organisme : ministry of education, culture, sports, science and technology
ID : 18K17933
Organisme : ministry of education, culture, sports, science and technology
ID : 18K07354
Organisme : ministry of education, culture, sports, science and technology
ID : 25870677
Organisme : saitama medical university
ID : 17-B-1-23
Organisme : Grant from Ochiai memorial award
ID : 2021

Informations de copyright

© 2021. The Author(s).

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Auteurs

Kensuke Iwasa (K)

Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.

Shinji Yamamoto (S)

Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.

Kota Yamashina (K)

Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.

Nan Yagishita-Kyo (N)

Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.

Kei Maruyama (K)

Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.

Takeo Awaji (T)

Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.

Yoshinori Takei (Y)

Department of Translational Research and Cellular Therapeutics, School of Medicine, Faculty of Medicine, Toho University, 5-21-16 Omori-Nishi, Ota-ku, Tokyo, 143-8540, Japan.

Akira Hirasawa (A)

Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimo-Adachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Institute for Integrated Medical Sciences, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Keisuke Yoshikawa (K)

Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan. keisukey@saitama-med.ac.jp.
ORCID: 0000-0002-6348-6138

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A peripheral lipid sensor GPR120 remotely...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › A peripheral lipid sensor GPR120 remotely...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › A peripheral lipid sensor GPR120 remotely...
questionsmedicales.fr › Hormones gastrointestinales › Peptides glucagon-like › Glucagon-like peptide 1 › A peripheral lipid sensor GPR120 remotely...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › A peripheral lipid sensor GPR120 remotely...
questionsmedicales.fr › Hormones gastrointestinales › Peptides glucagon-like › Glucagon-like peptide 1 › Liraglutide › A peripheral lipid sensor GPR120 remotely...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A peripheral lipid sensor GPR120 remotely...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › A peripheral lipid sensor GPR120 remotely...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › A peripheral lipid sensor GPR120 remotely...
questionsmedicales.fr › Cellules › Névroglie › Microglie › A peripheral lipid sensor GPR120 remotely...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › A peripheral lipid sensor GPR120 remotely...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Maladies neuro-inflammatoires › A peripheral lipid sensor GPR120 remotely...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Prostaglandines D › Prostaglandine D2 › A peripheral lipid sensor GPR120 remotely...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › A peripheral lipid sensor GPR120 remotely...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Suppression génétique › A peripheral lipid sensor GPR120 remotely...