Optogenetic activation of striatal D1R and D2R cells differentially engages downstream connected areas beyond the basal ganglia.

Animals Basal Ganglia / metabolism Corpus Striatum / metabolism Female Male Mice Neostriatum / metabolism Neurons / metabolism Optogenetics Receptors, Dopamine D1 / metabolism Receptors, Dopamine D2 / metabolism
D1R/D2R basal ganglia brain networks caudate putamen direct/indirect pathway fMRI movement disorders opto-fMRI optogenetics

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
28 12 2021
Historique:
received: 08 03 2021
revised: 20 10 2021
accepted: 01 12 2021
entrez: 29 12 2021
pubmed: 30 12 2021
medline: 16 2 2022
Statut: ppublish

Résumé

The basal ganglia (BG) are a group of subcortical nuclei responsible for motor and executive function. Central to BG function are striatal cells expressing D1 (D1R) and D2 (D2R) dopamine receptors. D1R and D2R cells are considered functional antagonists that facilitate voluntary movements and inhibit competing motor patterns, respectively. However, whether they maintain a uniform function across the striatum and what influence they exert outside the BG is unclear. Here, we address these questions by combining optogenetic activation of D1R and D2R cells in the mouse ventrolateral caudoputamen with fMRI. Striatal D1R/D2R stimulation evokes distinct activity within the BG-thalamocortical network and differentially engages cerebellar and prefrontal regions. Computational modeling of effective connectivity confirms that changes in D1R/D2R output drive functional relationships between these regions. Our results suggest a complex functional organization of striatal D1R/D2R cells and hint toward an interconnected fronto-BG-cerebellar network modulated by striatal D1R and D2R cells.

Identifiants

DOI: 10.1016/j.celrep.2021.110161 PMID: 34965430
pubmed: 34965430
pii: S2211-1247(21)01657-0
doi: 10.1016/j.celrep.2021.110161
pii:
doi:

Substances chimiques

Receptors, Dopamine D1 0
Receptors, Dopamine D2 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

110161

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Christina Grimm (C)

Neural Control of Movement Lab, Department of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland; Neuroscience Center Zurich, ETH Zürich and University of Zurich, Zürich, Switzerland.

Stefan Frässle (S)

Translational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zürich and ETH Zürich, Zürich, Switzerland.

Céline Steger (C)

Neuroscience Center Zurich, ETH Zürich and University of Zurich, Zürich, Switzerland; Center for MR Research, University Children's Hospital Zurich, Zürich, Switzerland.

Lukas von Ziegler (L)

Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland; Neuroscience Center Zurich, ETH Zürich and University of Zurich, Zürich, Switzerland.

Oliver Sturman (O)

Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland; Neuroscience Center Zurich, ETH Zürich and University of Zurich, Zürich, Switzerland.

Noam Shemesh (N)

Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal.

Daria Peleg-Raibstein (D)

Laboratory of Neurobehavioral Dynamics, Department of Health Sciences and Technology, Institute for Neuroscience, ETH Zürich, Zürich, Switzerland; Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Zürich, Switzerland.

Denis Burdakov (D)

Laboratory of Neurobehavioral Dynamics, Department of Health Sciences and Technology, Institute for Neuroscience, ETH Zürich, Zürich, Switzerland; Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Zürich, Switzerland; Neuroscience Center Zurich, ETH Zürich and University of Zurich, Zürich, Switzerland.

Johannes Bohacek (J)

Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland; Neuroscience Center Zurich, ETH Zürich and University of Zurich, Zürich, Switzerland.

Klaas Enno Stephan (KE)

Translational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zürich and ETH Zürich, Zürich, Switzerland.

Daniel Razansky (D)

Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zürich, Zürich, Switzerland; Institute of Biological and Medical Imaging (IBMI), Technical University of Munich and Helmholtz Center Munich, Munich, Germany; Neuroscience Center Zurich, ETH Zürich and University of Zurich, Zürich, Switzerland.

Nicole Wenderoth (N)

Neural Control of Movement Lab, Department of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland; Neuroscience Center Zurich, ETH Zürich and University of Zurich, Zürich, Switzerland.

Valerio Zerbi (V)

Neural Control of Movement Lab, Department of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland; Neuroscience Center Zurich, ETH Zürich and University of Zurich, Zürich, Switzerland. Electronic address: valerio.zerbi@hest.ethz.ch.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Optogenetic activation of striatal D1R and D2R...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Optogenetic activation of striatal D1R and D2R...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Optogenetic activation of striatal D1R and D2R...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Optogenetic activation of striatal D1R and D2R...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Néostriatum › Optogenetic activation of striatal D1R and D2R...
questionsmedicales.fr › Cellules › Neurones › Optogenetic activation of striatal D1R and D2R...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Optogénétique › Optogenetic activation of striatal D1R and D2R...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs catécholaminergiques › Récepteurs dopaminergiques › Récepteur dopamine D1 › Optogenetic activation of striatal D1R and D2R...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs catécholaminergiques › Récepteurs dopaminergiques › Récepteur D2 de la dopamine › Optogenetic activation of striatal D1R and D2R...