Pancreatectomy With Artery
Adenocarcinoma
/ diagnostic imaging
Adult
Aged
Female
Hepatic Artery
/ pathology
Humans
Indocyanine Green
/ administration & dosage
Male
Middle Aged
Pancreas
/ pathology
Pancreatic Neoplasms
/ diagnostic imaging
Pancreaticoduodenectomy
/ trends
Pilot Projects
Portal Vein
/ pathology
Postoperative Complications
Pancreatic Neoplasms
Pancreas neck cancer
artery reconstruction
artery resection
indocyanine green fluorescence imaging
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
07
10
2021
revised:
27
10
2021
accepted:
29
11
2021
entrez:
31
12
2021
pubmed:
1
1
2022
medline:
14
1
2022
Statut:
ppublish
Résumé
The potential benefits of pancreatectomy with major arterial resection have been studied in the past, but findings remain controversial. Pancreatic neck/body cancer (PNBC) involving arteries frequently requires combined resection of the pancreas, artery and portal vein. Nine prospectively-registered consecutive patients with PNBC were enrolled, all underwent pancreatoduodenectomy with common hepatic artery en-bloc resection (PD-CHAR). We investigated the safety of PD-CHAR by blood flow evaluation with intraoperative indocyanine green fluorescence imaging in reconstructed vessels/organs. Among patients who underwent PD-CHAR, there was no severe morbidity. Artery/portal vein combined resection and reconstruction was performed in all patients. Four (44%) patients had pathological positivity for cancer cell invasion into the nerve plexus of artery at the site of radiographic artery involvement, although one (11%) was diagnosed with pathological artery involvement. PD-CHAR following neoadjuvant therapy might be feasible for PNBC without severe postoperative complications. Survival benefits in PNBC should be confirmed in further studies.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
The potential benefits of pancreatectomy with major arterial resection have been studied in the past, but findings remain controversial. Pancreatic neck/body cancer (PNBC) involving arteries frequently requires combined resection of the pancreas, artery and portal vein.
PATIENTS AND METHODS
METHODS
Nine prospectively-registered consecutive patients with PNBC were enrolled, all underwent pancreatoduodenectomy with common hepatic artery en-bloc resection (PD-CHAR). We investigated the safety of PD-CHAR by blood flow evaluation with intraoperative indocyanine green fluorescence imaging in reconstructed vessels/organs.
RESULTS
RESULTS
Among patients who underwent PD-CHAR, there was no severe morbidity. Artery/portal vein combined resection and reconstruction was performed in all patients. Four (44%) patients had pathological positivity for cancer cell invasion into the nerve plexus of artery at the site of radiographic artery involvement, although one (11%) was diagnosed with pathological artery involvement.
CONCLUSION
CONCLUSIONS
PD-CHAR following neoadjuvant therapy might be feasible for PNBC without severe postoperative complications. Survival benefits in PNBC should be confirmed in further studies.
Identifiants
pubmed: 34969728
pii: 42/1/217
doi: 10.21873/anticanres.15476
doi:
Substances chimiques
Indocyanine Green
IX6J1063HV
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
217-227Informations de copyright
Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.