Allergen disrupts amygdala-respiration coupling.

Allergens / pharmacology Amygdala / physiopathology Animals Asthma / physiopathology Brain Waves / physiology Disease Models, Animal Hypersensitivity / physiopathology Inflammation / physiopathology Rats Respiratory Center / physiopathology Respiratory Rate / physiology
Allergic asthma Amygdala activity Amygdala-respiration coupling Respiration rhythm

Journal

Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022

Informations de publication

Date de publication:
03 2022
Historique:
received: 27 08 2021
revised: 25 11 2021
accepted: 27 12 2021
pubmed: 1 1 2022
medline: 1 3 2022
entrez: 31 12 2021
Statut: ppublish

Résumé

Allergic asthma affects both the respiratory function and central nervous system. Communication between the amygdala and respiratory control system is critical for regulating breathing function. To date, no study provides the effect of allergic inflammation on amygdala-respiration coupling. Here, we simultaneously recorded respiration and local field potentials of the amygdala during awake immobility in a rat model of allergic asthma. A decreased synchrony was found between amygdala and respiration in asthmatic rats. Allergen also reduced the modulatory effect of the respiration phase on amygdala power at delta, theta and gamma2 (80-120 Hz) frequencies. Moreover, in the animal model of allergic asthma, delta and theta oscillations strongly coordinate local gamma2 activity in the amygdala. These findings suggest that allergen can induce brain alterations and therefore shed light on future works to address how disruption of amygdala-respiration coupling contributes to respiratory dysfunction in allergic asthma.

Identifiants

DOI: 10.1016/j.resp.2021.103835 PMID: 34971764
pubmed: 34971764
pii: S1569-9048(21)00221-4
doi: 10.1016/j.resp.2021.103835
pii:
doi:

Substances chimiques

Allergens 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103835

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Kolsoum Dehdar (K)

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Morteza Salimi (M)

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Mohammad Reza Raoufy (MR)

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Institute for Brain Sciences and Cognition, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: raoufy@modares.ac.ir.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Antigènes › Allergènes › Allergen disrupts amygdala-respiration coupling.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Amygdale (système limbique) › Allergen disrupts amygdala-respiration coupling.
questionsmedicales.fr › Eucaryotes › Animaux › Allergen disrupts amygdala-respiration coupling.
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Allergen disrupts amygdala-respiration coupling.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Ondes du cerveau › Allergen disrupts amygdala-respiration coupling.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Allergen disrupts amygdala-respiration coupling.
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Allergen disrupts amygdala-respiration coupling.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Allergen disrupts amygdala-respiration coupling.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Allergen disrupts amygdala-respiration coupling.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Formation réticulaire › Centre respiratoire › Allergen disrupts amygdala-respiration coupling.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Respiration › Fréquence respiratoire › Allergen disrupts amygdala-respiration coupling.