Similar Gut Hormone Secretions Two Years After One Anastomosis Gastric Bypass and Roux-en-Y Gastric Bypass: a Pilot Study.

Anastomosis, Roux-en-Y / methods Blood Glucose / analysis C-Peptide Gastric Bypass / methods Ghrelin Glucagon-Like Peptide 1 Glucose Humans Insulin Obesity, Morbid / surgery Pilot Projects Weight Loss
GIP GLP-1 Gut hormones One anastomosis gastric bypass Roux-en-Y gastric bypass

Journal

Obesity surgery
ISSN: 1708-0428
Titre abrégé: Obes Surg
Pays: United States
ID NLM: 9106714

Informations de publication

Date de publication:
03 2022
Historique:
received: 02 07 2021
accepted: 04 12 2021
revised: 18 11 2021
pubmed: 8 1 2022
medline: 27 4 2022
entrez: 7 1 2022
Statut: ppublish

Résumé

One-anastomosis gastric bypass (OAGB) is as effective as Roux-en-Y gastric bypass (RYGB) regarding weight loss and diabetes remission. However, there are no data on gut hormone secretions after OAGB. The aim of this study was to compare fasting and postprandial secretions of gut and pancreatic hormones in OAGB versus RYGB patients. Twenty-nine patients, 16 OAGB- and 13 RYGB-operated, underwent a liquid mixed-meal tolerance test at 2 years' post-surgery. Blood was sampled before and 15, 30, 60, 90, and 120 min after meal for plasma measurement of glucose, C-peptide, insulin, glucagon, GLP-1, GIP, GLP-2, PYY, and ghrelin. Percentage of total weight loss 2 years post-surgery were -33.9 ± 1.8% for OAGB and -31.2 ± 1.6% for RYGB (p = 0.6). Four patients with persistent diabetes were excluded for further analysis. Fasting and postprandial glucose levels (peaks and area under curve values) were similar between groups. HOMA index was lower in the OAGB group (0.8 ± 0.1 vs 1.3 ± 0.2 in RYGB, p < 0.05). Levels of C-peptide (or insulin) measured at 30 min were significantly lower in OAGB vs RYGB patients (6.9 ± 0.5 vs 9.7 ± 1.1 µg/l, p < 0.05). No difference was observed between OAGB and RYGB groups for GLP-1, GLP-2, PYY, or ghrelin postprandial secretions, but GIP tended to be lower in OAGB vs RYGB patients (756 ± 155 vs 1100 ± 188 pg/ml for postprandial peak concentrations, p = 0.06). This is the first clinical study showing that OAGB procedure, like RYGB, results in high postprandial secretions of gut hormones, in particular GLP-1. Clinical Trials NCT03482895.

Identifiants

DOI: 10.1007/s11695-021-05837-5 PMID: 34993850
pubmed: 34993850
doi: 10.1007/s11695-021-05837-5
pii: 10.1007/s11695-021-05837-5
doi:

Substances chimiques

Blood Glucose 0
C-Peptide 0
Ghrelin 0
Insulin 0
Glucagon-Like Peptide 1 89750-14-1
Glucose IY9XDZ35W2

Banques de données

ClinicalTrials.gov
['NCT03482895']

Types de publication

Clinical Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

757-762

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Références

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Auteurs

David De Bandt (D)

AP-HP, Hôpital Européen Georges-Pompidou, Nutrition, APHP.Centre - Université de Paris, Paris, France.

Claire Rives-Lange (C)

AP-HP, Hôpital Européen Georges-Pompidou, Nutrition, APHP.Centre - Université de Paris, Paris, France.

Yvann Frigout (Y)

AP-HP, Hôpital Européen Georges-Pompidou, Unité de Recherche Clinique, APHP.Centre - Université de Paris, Paris, France.
INSERM, Centre d'Investigation Clinique 1418, Hôpital Européen Georges-Pompidou, APHP.Centre - Université de Paris, Paris, France.

Damien Bergerot (D)

INSERM, Centre d'Investigation Clinique 1418, Hôpital Européen Georges-Pompidou, APHP.Centre - Université de Paris, Paris, France.

Anne Blanchard (A)

INSERM, Centre d'Investigation Clinique 1418, Hôpital Européen Georges-Pompidou, APHP.Centre - Université de Paris, Paris, France.

Maude Le Gall (M)

INSERM, UMR 1149 Centre de Recherche Sur L'Inflammation, Université de Paris, Paris, France.

Jean-Marc Lacorte (JM)

AP-HP, Hôpital Pitié-Salpêtrière, Biochimie Endocrinienne Et Oncologique, APHP.6 - Sorbonne Université, Paris, France.

Jean-Marc Chevallier (JM)

AP-HP, Hôpital Européen Georges-Pompidou, Chirurgie digestive, APHP.Centre - Université de Paris, Paris, France.

Sébastien Czernichow (S)

AP-HP, Hôpital Européen Georges-Pompidou, Nutrition, APHP.Centre - Université de Paris, Paris, France.

Tigran Poghosyan (T)

AP-HP, Hôpital Européen Georges-Pompidou, Chirurgie digestive, APHP.Centre - Université de Paris, Paris, France.

Claire Carette (C)

AP-HP, Hôpital Européen Georges-Pompidou, Nutrition, APHP.Centre - Université de Paris, Paris, France.
INSERM, Centre d'Investigation Clinique 1418, Hôpital Européen Georges-Pompidou, APHP.Centre - Université de Paris, Paris, France.

Johanne Le Beyec (J)

INSERM, UMR 1149 Centre de Recherche Sur L'Inflammation, Université de Paris, Paris, France. johanne.lebihan@aphp.fr.
AP-HP, Hôpital Pitié-Salpêtrière, Biochimie Endocrinienne Et Oncologique, APHP.6 - Sorbonne Université, Paris, France. johanne.lebihan@aphp.fr.

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Classifications MeSH

questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie digestive › Anastomose de Roux-en-Y › Similar Gut Hormone Secretions Two Years After...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Similar Gut Hormone Secretions Two Years After...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Peptide C › Similar Gut Hormone Secretions Two Years After...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie digestive › Gastroentérostomie › Dérivation gastrique › Similar Gut Hormone Secretions Two Years After...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Ghréline › Similar Gut Hormone Secretions Two Years After...
questionsmedicales.fr › Hormones gastrointestinales › Peptides glucagon-like › Glucagon-like peptide 1 › Similar Gut Hormone Secretions Two Years After...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Similar Gut Hormone Secretions Two Years After...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Similar Gut Hormone Secretions Two Years After...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Similar Gut Hormone Secretions Two Years After...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Obésité morbide › Similar Gut Hormone Secretions Two Years After...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Projets pilotes › Similar Gut Hormone Secretions Two Years After...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Poids › Modifications du poids corporel › Perte de poids › Similar Gut Hormone Secretions Two Years After...