One-Pot Synthesis and Antiproliferative Activity of Highly Functionalized Pyrazole Derivatives.
antiproliferative agents
docking simulations
one-pot synthesis
pyrazole derivatives
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
04 03 2022
04 03 2022
Historique:
revised:
28
12
2021
received:
20
10
2021
pubmed:
8
1
2022
medline:
3
5
2022
entrez:
7
1
2022
Statut:
ppublish
Résumé
A series of highly functionalized pyrazole derivatives has been prepared by a one-pot, versatile and regioselective procedure. Pyrazoles 1-29 were tested in cell-based assay to assess their antiproliferative activity against a panel of tumour cells. Additionally, the cytotoxicity of prepared compounds was evaluated against normal human fibroblasts. The antiproliferative activity of the synthesized molecules emerged to be affected by the nature of the substituents of the pyrazole scaffold and derivatives 21-23 proved to inhibit the growth of melanoma and cervical cancer cells. Compound 23 was identified as the most active derivative and docking simulations predicted its ability to interact with estrogen receptors.
Identifiants
pubmed: 34994095
doi: 10.1002/cmdc.202100670
doi:
Substances chimiques
Antineoplastic Agents
0
Pyrazoles
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202100670Informations de copyright
© 2022 Wiley-VCH GmbH.
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