Use of Tranexamic Acid for Elective Resection of Intracranial Neoplasms: A Systematic Review.

Antifibrinolytic Agents / therapeutic use Blood Loss, Surgical / prevention & control Brain Neoplasms / surgery Humans Prospective Studies Retrospective Studies Tranexamic Acid / therapeutic use
Intracranial Neoplasms Skull base Tranexamic acid

Journal

World neurosurgery
ISSN: 1878-8769
Titre abrégé: World Neurosurg
Pays: United States
ID NLM: 101528275

Informations de publication

Date de publication:
04 2022
Historique:
received: 27 11 2021
revised: 29 12 2021
accepted: 30 12 2021
pubmed: 8 1 2022
medline: 6 4 2022
entrez: 7 1 2022
Statut: ppublish

Résumé

As an established antifibrinolytic agent, tranexamic acid (TXA) has garnered widespread use during surgery to limit intraoperative blood loss. In the field of neurosurgery, TXA is often introduced in cases of traumatic brain injury or elective spine surgeries; however, its role during elective cranial surgeries is not well established. We report a systematic review of the use of TXA in elective surgical resection of intracranial neoplasms. We performed this systematic review following PRISMA guidelines to identify studies investigating the use of TXA in elective neurosurgical resection of intracranial neoplasms. Variables extracted included patient demographics, surgical indications, type of surgery performed, TXA dose and route of administration, operative duration, blood loss, transfusion rate, postoperative hemoglobin level, and complications. After careful screening, 4 articles (consisting of 682 patients) met our inclusion/exclusion criteria. The studies included 2 prospective cohort studies, 1 retrospective cohort study, and 1 case series. A χ These results support the use of intraoperative TXA in tumor resection. However, its role in tumor resection has been less well investigated compared with its use in other areas of neurosurgery.

Sections du résumé

BACKGROUND
As an established antifibrinolytic agent, tranexamic acid (TXA) has garnered widespread use during surgery to limit intraoperative blood loss. In the field of neurosurgery, TXA is often introduced in cases of traumatic brain injury or elective spine surgeries; however, its role during elective cranial surgeries is not well established. We report a systematic review of the use of TXA in elective surgical resection of intracranial neoplasms.
METHODS
We performed this systematic review following PRISMA guidelines to identify studies investigating the use of TXA in elective neurosurgical resection of intracranial neoplasms. Variables extracted included patient demographics, surgical indications, type of surgery performed, TXA dose and route of administration, operative duration, blood loss, transfusion rate, postoperative hemoglobin level, and complications.
RESULTS
After careful screening, 4 articles (consisting of 682 patients) met our inclusion/exclusion criteria. The studies included 2 prospective cohort studies, 1 retrospective cohort study, and 1 case series. A χ
CONCLUSIONS
These results support the use of intraoperative TXA in tumor resection. However, its role in tumor resection has been less well investigated compared with its use in other areas of neurosurgery.

Identifiants

DOI: 10.1016/j.wneu.2021.12.117 PMID: 34995825
pubmed: 34995825
pii: S1878-8750(21)01962-8
doi: 10.1016/j.wneu.2021.12.117
pii:
doi:

Substances chimiques

Antifibrinolytic Agents 0
Tranexamic Acid 6T84R30KC1

Types de publication

Journal Article Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e209-e219

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Nolan J Brown (NJ)

Department of Neurological Surgery, University of California Irvine, Irvine, California, USA.

Bayard Wilson (B)

Department of Neurological Surgery, University of California Los Angeles, Los Angeles, California, USA.

Vera Ong (V)

John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.

Julian L Gendreau (JL)

Department of Biomedical Engineering, Johns Hopkins Whiting School of Engineering, Baltimore, Maryland, USA. Electronic address: jgendre1@jhu.edu.

Chen Yi Yang (CY)

Department of Neurological Surgery, University of California Irvine, Irvine, California, USA.

Alexander S Himstead (AS)

Department of Neurological Surgery, University of California Irvine, Irvine, California, USA.

Shane Shahrestani (S)

Keck School of Medicine of USC, Los Angeles, California, USA; Medical Scientist Training Program, California Institute of Technology, Pasadena, California, USA.

Nathan A Shlobin (NA)

Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Taylor Reardon (T)

Kentucky College of Osteopathic Medicine, University of Pikeville, Pikeville, Kentucky, USA.

Elliot H Choi (EH)

Department of Neurological Surgery, University of California Irvine, Irvine, California, USA.

Jack Birkenbeuel (J)

Department of Neurological Surgery, University of California Irvine, Irvine, California, USA.

Sebastian J Cohn (SJ)

Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Ronald Sahyouni (R)

Department of Neurological Surgery, University of California San Diego, La Jolla, California, USA.

Isaac Yang (I)

Department of Neurological Surgery, University of California Los Angeles, Los Angeles, California, USA.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents hématologiques › Coagulants › Hémostatiques › Antifibrinolytiques › Use of Tranexamic Acid for Elective Resection...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications peropératoires › Perte sanguine peropératoire › Use of Tranexamic Acid for Elective Resection...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Use of Tranexamic Acid for Elective Resection...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Use of Tranexamic Acid for Elective Resection...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Use of Tranexamic Acid for Elective Resection...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Use of Tranexamic Acid for Elective Resection...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Acide tranéxamique › Use of Tranexamic Acid for Elective Resection...