Robotic system for top to bottom MRgFUS therapy of multiple cancer types.
MRI compatible
ex vivo tissue ablation
focussed ultrasound
multipurpose
robotic system
top to bottom
Journal
The international journal of medical robotics + computer assisted surgery : MRCAS
ISSN: 1478-596X
Titre abrégé: Int J Med Robot
Pays: England
ID NLM: 101250764
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
revised:
05
01
2022
received:
10
12
2021
accepted:
05
01
2022
pubmed:
8
1
2022
medline:
4
3
2022
entrez:
7
1
2022
Statut:
ppublish
Résumé
A robotic system for Magnetic Resonance guided Focussed Ultrasound (MRgFUS) therapy of tumours in the breast, bone, thyroid, and abdomen was developed. A special C-shaped structure was designed to be attached to the table of conventional magnetic resonance imaging (MRI) systems carrying 4 computer-controlled motion stages dedicated to positioning a 2.75 MHz spherically focussed transducer relative to a patient placed in the supine position. The developed system was evaluated for its MRI compatibility and heating abilities in agar-based phantoms and freshly excised tissue. Compatibility of the system with a clinical high-field MRI scanner was demonstrated. FUS heating in the phantom was successfully monitored by magnetic resonance thermometry without any evidence of magnetically induced phenomena. Cigar-shaped discrete lesions and well-defined areas of overlapping lesions were inflicted in excised tissue by robotic movement along grid patterns. The developed MRgFUS robotic system was proven safe and efficient by ex-vivo feasibility studies.
Sections du résumé
BACKGROUND
BACKGROUND
A robotic system for Magnetic Resonance guided Focussed Ultrasound (MRgFUS) therapy of tumours in the breast, bone, thyroid, and abdomen was developed.
METHODS
METHODS
A special C-shaped structure was designed to be attached to the table of conventional magnetic resonance imaging (MRI) systems carrying 4 computer-controlled motion stages dedicated to positioning a 2.75 MHz spherically focussed transducer relative to a patient placed in the supine position. The developed system was evaluated for its MRI compatibility and heating abilities in agar-based phantoms and freshly excised tissue.
RESULTS
RESULTS
Compatibility of the system with a clinical high-field MRI scanner was demonstrated. FUS heating in the phantom was successfully monitored by magnetic resonance thermometry without any evidence of magnetically induced phenomena. Cigar-shaped discrete lesions and well-defined areas of overlapping lesions were inflicted in excised tissue by robotic movement along grid patterns.
CONCLUSIONS
CONCLUSIONS
The developed MRgFUS robotic system was proven safe and efficient by ex-vivo feasibility studies.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2364Subventions
Organisme : Research and Innovation Foundation of Cyprus
ID : SOUNDPET (INTEGRATED/0918/0008)
Organisme : Research and Innovation Foundation of Cyprus under the project SOUNDPET
ID : INTEGRATED/0918/0008
Informations de copyright
© 2022 John Wiley & Sons Ltd.
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