Feeding Brassica vegetables to rats leads to the formation of characteristic DNA adducts (from 1-methoxy-3-indolylmethyl glucosinolate) in many tissues.
Broccoli
DNA adducts
Glucosinolates
Neoglucobrassicin
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
17
07
2021
accepted:
23
12
2021
pubmed:
9
1
2022
medline:
30
3
2022
entrez:
8
1
2022
Statut:
ppublish
Résumé
Juices of Brassica vegetables are mutagenic and form characteristic DNA adducts in bacteria and mammalian cells. In this study, we examined whether such adducts are also formed in vivo in animal models. Rats fed raw broccoli ad libitum in addition to normal laboratory chow for 5 weeks showed one major adduct spot and sometimes an additional minor adduct spot in liver, kidney, lung, blood and the gastrointestinal tract, as determined by
Identifiants
pubmed: 34997255
doi: 10.1007/s00204-021-03216-8
pii: 10.1007/s00204-021-03216-8
pmc: PMC8850215
doi:
Substances chimiques
1-methoxy-3-indolylmethyl glucosinolate
0
DNA Adducts
0
Glucosinolates
0
Indoles
0
neoglucobrassicin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
933-944Informations de copyright
© 2022. The Author(s).
Références
Food Funct. 2014 Jun;5(6):1073-81
pubmed: 24714741
Mutat Res. 1999 Mar 8;424(1-2):237-47
pubmed: 10064864
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3147-50
pubmed: 8159717
Mol Nutr Food Res. 2007 Dec;51(12):1537-46
pubmed: 18030659
Nat Protoc. 2007;2(11):2772-81
pubmed: 18007613
Chem Biol Interact. 2011 Jun 30;192(1-2):81-6
pubmed: 20846518
Int J Mol Sci. 2013 Jul 18;14(7):14996-5016
pubmed: 23873294
Proc Natl Acad Sci U S A. 1984 Nov;81(22):6943-7
pubmed: 6594673
Nature. 2019 Feb;566(7743):249-253
pubmed: 30700914
Mutat Res. 1995 Feb;341(4):265-79
pubmed: 7531286
Arch Toxicol. 2014 Mar;88(3):823-36
pubmed: 24154822
Arch Toxicol. 2019 Jun;93(6):1515-1527
pubmed: 30993378
Chem Res Toxicol. 2012 Oct 15;25(10):2007-35
pubmed: 22827593
Chem Res Toxicol. 2014 Feb 17;27(2):188-99
pubmed: 24422435
Chem Res Toxicol. 1996 Jan-Feb;9(1):247-54
pubmed: 8924599
J Agric Food Chem. 2015 Sep 30;63(38):8418-28
pubmed: 26365197
Anal Chem. 2017 Nov 7;89(21):11728-11736
pubmed: 28977750
Chem Biol Interact. 1996 Sep 27;102(1):1-16
pubmed: 8827059
Mol Nutr Food Res. 2011 May;55(5):783-92
pubmed: 21213326
Anal Chem. 2012 Jul 17;84(14):6256-62
pubmed: 22816785
Mutagenesis. 2011 May;26(3):407-13
pubmed: 21193518
Food Chem Toxicol. 2014 May;67:10-6
pubmed: 24530313
Mol Nutr Food Res. 2015 Apr;59(4):685-97
pubmed: 25559983