EEG and fMRI coupling and decoupling based on joint independent component analysis (jICA).
Auditory Processing
EEG
Event-Related Potentials (ERPs)
FMRI
Joint Independent Component Analysis (jICA)
Speech
Spoken Syllables
Journal
Journal of neuroscience methods
ISSN: 1872-678X
Titre abrégé: J Neurosci Methods
Pays: Netherlands
ID NLM: 7905558
Informations de publication
Date de publication:
01 Mar 2022
01 Mar 2022
Historique:
received:
01
09
2021
revised:
20
12
2021
accepted:
04
01
2022
pubmed:
10
1
2022
medline:
8
4
2022
entrez:
9
1
2022
Statut:
ppublish
Résumé
Meaningful integration of functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) requires knowing whether these measurements reflect the activity of the same neural sources, i.e., estimating the degree of coupling and decoupling between the neuroimaging modalities. This paper proposes a method to quantify the coupling and decoupling of fMRI and EEG signals based on the mixing matrix produced by joint independent component analysis (jICA). The method is termed fMRI/EEG-jICA. fMRI and EEG acquired during a syllable detection task with variable syllable presentation rates (0.25-3 Hz) were separated with jICA into two spatiotemporally distinct components, a primary component that increased nonlinearly in amplitude with syllable presentation rate, putatively reflecting an obligatory auditory response, and a secondary component that declined nonlinearly with syllable presentation rate, putatively reflecting an auditory attention orienting response. The two EEG subcomponents were of similar amplitude, but the secondary fMRI subcomponent was ten folds smaller than the primary one. FMRI multiple regression analysis yielded a map more consistent with the primary than secondary fMRI subcomponent of jICA, as determined by a greater area under the curve (0.5 versus 0.38) in a sensitivity and specificity analysis of spatial overlap. fMRI/EEG-jICA revealed spatiotemporally distinct brain networks with greater sensitivity than fMRI multiple regression analysis, demonstrating how this method can be used for leveraging EEG signals to inform the detection and functional characterization of fMRI signals. fMRI/EEG-jICA may be useful for studying neurovascular coupling at a macro-level, e.g., in neurovascular disorders.
Sections du résumé
BACKGROUND
BACKGROUND
Meaningful integration of functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) requires knowing whether these measurements reflect the activity of the same neural sources, i.e., estimating the degree of coupling and decoupling between the neuroimaging modalities.
NEW METHOD
METHODS
This paper proposes a method to quantify the coupling and decoupling of fMRI and EEG signals based on the mixing matrix produced by joint independent component analysis (jICA). The method is termed fMRI/EEG-jICA.
RESULTS
RESULTS
fMRI and EEG acquired during a syllable detection task with variable syllable presentation rates (0.25-3 Hz) were separated with jICA into two spatiotemporally distinct components, a primary component that increased nonlinearly in amplitude with syllable presentation rate, putatively reflecting an obligatory auditory response, and a secondary component that declined nonlinearly with syllable presentation rate, putatively reflecting an auditory attention orienting response. The two EEG subcomponents were of similar amplitude, but the secondary fMRI subcomponent was ten folds smaller than the primary one.
COMPARISON TO EXISTING METHOD
METHODS
FMRI multiple regression analysis yielded a map more consistent with the primary than secondary fMRI subcomponent of jICA, as determined by a greater area under the curve (0.5 versus 0.38) in a sensitivity and specificity analysis of spatial overlap.
CONCLUSION
CONCLUSIONS
fMRI/EEG-jICA revealed spatiotemporally distinct brain networks with greater sensitivity than fMRI multiple regression analysis, demonstrating how this method can be used for leveraging EEG signals to inform the detection and functional characterization of fMRI signals. fMRI/EEG-jICA may be useful for studying neurovascular coupling at a macro-level, e.g., in neurovascular disorders.
Identifiants
pubmed: 34998799
pii: S0165-0270(22)00004-8
doi: 10.1016/j.jneumeth.2022.109477
pmc: PMC8879823
mid: NIHMS1770708
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109477Subventions
Organisme : NCRR NIH HHS
ID : M01 RR000058
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC006287
Pays : United States
Organisme : NIDCD NIH HHS
ID : R21 DC004880
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
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