Co-opting disorder into order: Intrinsically disordered proteins and the early evolution of complex multicellularity.

Intrinsically Disordered Proteins Volvox
Chlamydomonas reinhardtii Complex systems Intrinsically disordered proteins Multicellularity Protein interaction networks RegA protein Self-organization Volvox carteri

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
15 Mar 2022
Historique:
received: 29 11 2021
revised: 18 12 2021
accepted: 28 12 2021
pubmed: 10 1 2022
medline: 1 4 2022
entrez: 9 1 2022
Statut: ppublish

Résumé

Intrinsically disordered proteins (IDPs) are proteins that lack rigid structures yet play important roles in myriad biological phenomena. A distinguishing feature of IDPs is that they often mediate specific biological outcomes via multivalent weak cooperative interactions with multiple partners. Here, we show that several proteins specifically associated with processes that were key in the evolution of complex multicellularity in the lineage leading to the multicellular green alga Volvox carteri are IDPs. We suggest that, by rewiring cellular protein interaction networks, IDPs facilitated the co-option of ancestral pathways for specialized multicellular functions, underscoring the importance of IDPs in the early evolution of complex multicellularity.

Identifiants

DOI: 10.1016/j.ijbiomac.2021.12.182 PMID: 34998872
pubmed: 34998872
pii: S0141-8130(21)02826-9
doi: 10.1016/j.ijbiomac.2021.12.182
pii:
doi:

Substances chimiques

Intrinsically Disordered Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

29-36

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

Auteurs

Prakash Kulkarni (P)

Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA, USA. Electronic address: pkulkarni@coh.org.

Amita Behal (A)

Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA, USA.

Atish Mohanty (A)

Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA, USA.

Ravi Salgia (R)

Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA, USA.

Aurora M Nedelcu (AM)

Department of Biology, University of New Brunswick, Fredericton, Canada. Electronic address: anedelcu@unb.ca.

Vladimir N Uversky (VN)

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA; Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutskiy pereulok, 9, Dolgoprudny, Moscow region 141700, Russia. Electronic address: vuversky@usf.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines intrinsèquement désordonnées › Co-opting disorder into order: Intrinsically...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Chlorophyta › Volvox › Co-opting disorder into order: Intrinsically...