Ceramide signaling in the gut.
Ceramide
Colon cancer
Inflammatory bowel disease
Intestine
NAFLD
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
15 03 2022
15 03 2022
Historique:
received:
07
06
2021
revised:
29
12
2021
accepted:
03
01
2022
pubmed:
10
1
2022
medline:
5
4
2022
entrez:
9
1
2022
Statut:
ppublish
Résumé
Sphingolipids are essential lipid components in the intestinal epithelial cells (IEC) along the intestinal tract. They play crucial roles in maintaining barrier integrity, regulating nutrient absorption, and acting as signaling molecules to regulate regeneration and differentiation of intestinal mucosa (Kurek et al., 2012). Ceramide is the central sphingolipid species and the precursor of all complex sphingolipids and other downstream simple intermediates like sphingosine (SPH), ceramide-1-phosphate (C-1-P), and sphingosine-1-phosphate (S-1-P). It is also a critical signaling molecule regulating numerous physiologic and pathologic processes. This review will summarize the metabolism of ceramides in the gut and their regulation in inflammatory bowel diseases and colorectal cancer.
Identifiants
pubmed: 34998898
pii: S0303-7207(22)00001-6
doi: 10.1016/j.mce.2022.111554
pmc: PMC8828712
mid: NIHMS1771468
pii:
doi:
Substances chimiques
Ceramides
0
Lysophospholipids
0
Sphingolipids
0
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111554Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK115824
Pays : United States
Organisme : NIDDK NIH HHS
ID : R44 DK116450
Pays : United States
Organisme : NIDDK NIH HHS
ID : R43 DK116450
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK131609
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK130296
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK122001
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK091317
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
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