Are All Anxieties Created Equal? Stress-related Networks and Anxiety Phenotypes in Old Age.
Late Life
anxiety
connectivity
resting state
stress
worry
Journal
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
ISSN: 1545-7214
Titre abrégé: Am J Geriatr Psychiatry
Pays: England
ID NLM: 9309609
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
02
09
2021
revised:
01
12
2021
accepted:
08
12
2021
pubmed:
11
1
2022
medline:
9
6
2022
entrez:
10
1
2022
Statut:
ppublish
Résumé
The dysregulation of stress-related networks due to chronic symptoms such as severe worry and/or rumination is one of the putative pathways linking anxiety in late-life with cognitive decline and increased cardiovascular burden. Symptoms such as severe worry or rumination respond poorly to standard treatment and drive the morbidity associated with anxiety in older adults. We assessed if any of the neural networks anchored in the stress-related regions of interest (ROIs) are associated with distinct anxiety phenotypes (worry, rumination and global anxiety). We recruited older participants (over 50 years of age) with varying levels of worry (N = 91) to undergo resting state fMRI. We computed seed-based connectivity for each ROI: the bed nucleus of the stria terminalis, the paraventricular nucleus of the hypothalamus, habenula, and amygdala. We limited our connectivity analyses to extracted regions for each seeded ROI-based network based on their canonical networks in 1,000 participants (Neurosynth). Using connectivity and clinical factors, we fit cross-validated elastic net models to predict scores on Penn State Worry Questionnaire, Rumination Subscale Questionnaire, Hamilton Anxiety Rating Scale, and Perceived Stress Scale. We identified several distinct connectivity patterns that predict anxiety phenotypes' severity. Greater worry was associated with greater paraventricular nucleus of the hypothalamus -subgenual anterior cingulate cortex, parahippocampal, and olfactory and amygdala-PHC connectivity. Greater global anxiety was associated with lower amygdala-superior temporal gyrus connectivity. Greater perceived stress was associated with lower amygdala-inferior temporal gyrus and amygdala-fusiform gyrus connectivity. Our study suggests that various late-life anxiety phenotypes (worry, global anxiety, rumination) may be associated with varying functional connectivity related to stress and emotion regulation. This may aid in the development of future targeted interventions.
Identifiants
pubmed: 35000866
pii: S1064-7481(21)00560-1
doi: 10.1016/j.jagp.2021.12.007
pmc: PMC9177511
mid: NIHMS1763707
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
801-812Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM113243
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH019986
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG023651
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH108509
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG025516
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG055381
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH076079
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH121619
Pays : United States
Informations de copyright
Copyright © 2021 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.
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