ATP is an essential autocrine factor for pancreatic β-cell signaling and insulin secretion.


Journal

Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800

Informations de publication

Date de publication:
01 2022
Historique:
received: 30 08 2021
accepted: 05 09 2021
entrez: 10 1 2022
pubmed: 11 1 2022
medline: 5 4 2022
Statut: ppublish

Résumé

ATP has been previously identified as an autocrine signaling factor that is co-released with insulin to modulate and propagate β-cell activity within islets of Langerhans. Here, we show that β-cell activity and insulin secretion essentially rely on the presence of extracellular ATP. For this, we monitored changes of the intracellular Ca

Identifiants

pubmed: 35001557
doi: 10.14814/phy2.15159
pmc: PMC8743876
doi:

Substances chimiques

Insulin 0
Adenosine Triphosphate 8L70Q75FXE
Glucose IY9XDZ35W2
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e15159

Informations de copyright

© 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

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Auteurs

Sebastian Hauke (S)

Cell Biology & Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

Jona Rada (J)

Cell Biology & Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

Gergely Tihanyi (G)

Cell Biology & Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

Danny Schilling (D)

Cell Biology & Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

Carsten Schultz (C)

Cell Biology & Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Department of Chemical Physiology and Biochemistry, Oregon Health & Science University (OHSU), Portland, Oregon, USA.

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Classifications MeSH