Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton.

Aniline Compounds / chemical synthesis Benzamides / chemical synthesis Dose-Response Relationship, Drug Drug Design Humans Molecular Structure Naphthalenes / chemical synthesis Orexin Receptors / agonists Structure-Activity Relationship
Agonist Conformational restriction GPCR Naphthalene OX1R OX2R Orexin Orexin receptor

Journal

Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377

Informations de publication

Date de publication:
01 03 2022
Historique:
received: 24 11 2021
revised: 27 12 2021
accepted: 04 01 2022
pubmed: 11 1 2022
medline: 22 3 2022
entrez: 10 1 2022
Statut: ppublish

Résumé

A novel series of naphthalene derivatives were designed and synthesized based on the strategy focusing on the restriction of the flexible bond rotation of OX

Identifiants

DOI: 10.1016/j.bmcl.2022.128530 PMID: 35007725
pubmed: 35007725
pii: S0960-894X(22)00006-3
doi: 10.1016/j.bmcl.2022.128530
pii:
doi:

Substances chimiques

Aniline Compounds 0
Benzamides 0
Naphthalenes 0
Orexin Receptors 0
YNT-185 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

128530

Informations de copyright

Copyright © 2022. Published by Elsevier Ltd.

Auteurs

Tsubasa Hino (T)

Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan.

Tsuyoshi Saitoh (T)

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

Yasuyuki Nagumo (Y)

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

Naoshi Yamamoto (N)

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

Noriki Kutsumura (N)

Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

Yoko Irukayama-Tomobe (Y)

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

Yukiko Ishikawa (Y)

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

Ryuji Tanimura (R)

Pharmaceutical Research Laboratories, Toray Industries Inc., 10-1, Tebiro 6-choume, Kamakura, Kanagawa 248-8555, Japan.

Masashi Yanagisawa (M)

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; R&D Center for Frontiers of Mirai in Policy and Technology (F-MIRAI), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States.

Hiroshi Nagase (H)

Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. Electronic address: nagase.hiroshi.gt@u.tsukuba.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Dérivés de l'aniline › Design and synthesis of novel orexin 2...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Benzamides › Design and synthesis of novel orexin 2...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Design and synthesis of novel orexin 2...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Design and synthesis of novel orexin 2...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Design and synthesis of novel orexin 2...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Design and synthesis of novel orexin 2...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Design and synthesis of novel orexin 2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs des orexines › Design and synthesis of novel orexin 2...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Design and synthesis of novel orexin 2...