Exosomal MicroRNAs as Potential Biomarkers of Hepatic Injury and Kidney Disease in Glycogen Storage Disease Type Ia Patients.
Adolescent
Adult
Age Factors
Animals
Biomarkers
/ metabolism
Case-Control Studies
Child
Child, Preschool
Cohort Studies
Exosomes
/ genetics
Female
Gene Expression Profiling
Gene Expression Regulation
Gene Ontology
Glucose-6-Phosphatase
/ metabolism
Glycogen Storage Disease Type I
/ blood
Humans
Kidney Diseases
/ blood
Liver
/ injuries
Male
Mice
MicroRNAs
/ genetics
Middle Aged
Time Factors
Young Adult
GSDIa
biomarkers
exosomes
hepatocellular adenoma
kidney
liver
microRNA
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Dec 2021
28 Dec 2021
Historique:
received:
18
11
2021
revised:
15
12
2021
accepted:
23
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
3
2
2022
Statut:
epublish
Résumé
Glycogen storage disease type Ia (GSDIa) is an inherited metabolic disorder caused by mutations in the enzyme glucose-6-phosphatase-α (G6Pase-α). Affected individuals develop renal and liver complications, including the development of hepatocellular adenoma/carcinoma and kidney failure. The purpose of this study was to identify potential biomarkers of the evolution of the disease in GSDIa patients. To this end, we analyzed the expression of exosomal microRNAs (Exo-miRs) in the plasma exosomes of 45 patients aged 6 to 63 years. Plasma from age-matched normal individuals were used as controls. We found that the altered expression of several Exo-miRs correlates with the pathologic state of the patients and might help to monitor the progression of the disease and the development of late GSDIa-associated complications.
Identifiants
pubmed: 35008754
pii: ijms23010328
doi: 10.3390/ijms23010328
pmc: PMC8745197
pii:
doi:
Substances chimiques
Biomarkers
0
MicroRNAs
0
Glucose-6-Phosphatase
EC 3.1.3.9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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