DUSP-1 Induced by PGE

Adult Aged Aged, 80 and over Alprostadil / pharmacology Dinoprostone / pharmacology Dual Specificity Phosphatase 1 / metabolism Humans Interleukin-1beta / metabolism Intervertebral Disc / metabolism MAP Kinase Signaling System / drug effects Middle Aged Nerve Growth Factor / metabolism Phosphorylation / drug effects Protein Kinase Inhibitors / pharmacology RNA, Small Interfering / metabolism
dual-specificity phosphatase (DUSP)-1 interleukin-1β (IL-1β) intervertebral disc (IVD) mitogen-activated protein kinase (MAPK) nerve growth factor (NGF) prostaglandin E1 (PGE1) prostaglandin E2 (PGE2)

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
29 Dec 2021
Historique:
received: 26 11 2021
revised: 25 12 2021
accepted: 28 12 2021
entrez: 11 1 2022
pubmed: 12 1 2022
medline: 10 2 2022
Statut: epublish

Résumé

The molecular mechanism of discogenic low back pain (LBP) involves nonphysiological nerve invasion into a degenerated intervertebral disc (IVD), induced by nerve growth factor (NGF). Selective cyclooxygenase (COX)-2 inhibitors are mainly used in the treatment of LBP, and act by suppressing the inflammatory mediator prostaglandin E

Identifiants

DOI: 10.3390/ijms23010371 PMID: 35008797 PMC: PMC8745672
pubmed: 35008797
pii: ijms23010371
doi: 10.3390/ijms23010371
pmc: PMC8745672
pii:
doi:

Substances chimiques

Interleukin-1beta 0
Protein Kinase Inhibitors 0
RNA, Small Interfering 0
Nerve Growth Factor 9061-61-4
Dual Specificity Phosphatase 1 EC 3.1.3.48
Alprostadil F5TD010360
Dinoprostone K7Q1JQR04M

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Japan Society for the Promotion of Science
ID : 17K11028
Organisme : Japan Society for the Promotion of Science
ID : 19K09609

Références

Lancet. 2017 Sep 16;390(10100):1211-1259
pubmed: 28919117
Science. 1987 Sep 4;237(4819):1154-62
pubmed: 3306916
Biochem Biophys Res Commun. 2010 Dec 10;403(2):184-9
pubmed: 21059338
Spine (Phila Pa 1976). 2012 Mar 15;37(6):439-44
pubmed: 22020607
Arthritis Res Ther. 2005;7(4):R732-45
pubmed: 15987475
Eur Spine J. 2008 Dec;17 Suppl 4:428-31
pubmed: 19005695
Lancet. 1997 Jul 19;350(9072):178-81
pubmed: 9250186
Spine (Phila Pa 1976). 2008 Jul 15;33(16):1766-74
pubmed: 18580547
J Pathol. 2002 Jul;197(3):286-92
pubmed: 12115873
Spine (Phila Pa 1976). 2016 Jun;41(12):E710-E716
pubmed: 26656048
J Orthop Sci. 2013 Mar;18(2):208-15
pubmed: 23203845
Biochim Biophys Acta. 2005 Dec 30;1754(1-2):253-62
pubmed: 16198162
Pain. 2003 Jul;104(1-2):241-7
pubmed: 12855334
J Immunol. 2006 Feb 1;176(3):1899-907
pubmed: 16424221
Eur Spine J. 2003 Feb;12(1):66-75
pubmed: 12592549
Spine (Phila Pa 1976). 2000 Jan 15;25(2):166-9
pubmed: 10685479
Spine (Phila Pa 1976). 1997 Oct 15;22(20):2342-9; discussion 2349-50
pubmed: 9355214
Exp Neurol. 1990 Jul;109(1):111-30
pubmed: 2141574
Immunol Rev. 2009 Mar;228(1):212-24
pubmed: 19290930
Spine (Phila Pa 1976). 2012 Jan 1;37(1):18-25
pubmed: 22179320
Mol Med Rep. 2017 Dec;16(6):8441-8447
pubmed: 28983624
Spine (Phila Pa 1976). 2005 Jan 1;30(1):44-53; discussion 54
pubmed: 15626980
Life Sci. 2012 Feb 13;90(7-8):237-48
pubmed: 22197448
Spine (Phila Pa 1976). 2006 Oct 1;31(21):2418-22
pubmed: 17023849
Spine (Phila Pa 1976). 2002 Jun 15;27(12):1278-85
pubmed: 12065974
Eur Spine J. 2011 Jun;20(6):942-6
pubmed: 20953967
J Neurosci. 1993 May;13(5):2136-48
pubmed: 8478693
Protein Cell. 2010 Mar;1(3):218-26
pubmed: 21203968
Science. 2002 Dec 6;298(5600):1911-2
pubmed: 12471242
Arthritis Res Ther. 2008;10(4):R99
pubmed: 18727839
Br J Pharmacol. 1997 Sep;122(2):217-24
pubmed: 9313928
Pain. 2020 Sep 1;161(9):2068-2078
pubmed: 32453139
Osteoarthritis Cartilage. 2009 Dec;17(12):1662-9
pubmed: 19583958
J Exp Med. 2006 Aug 7;203(8):1883-9
pubmed: 16880258
Biomed Pharmacother. 2020 Nov;131:110660
pubmed: 32853910
Spine (Phila Pa 1976). 2013 Aug 1;38(17):1466-72
pubmed: 23574818
J Orthop Res. 2008 Jul;26(7):991-8
pubmed: 18302237
Neurology. 1997 Feb;48(2):501-5
pubmed: 9040746
Cell Res. 2005 Jan;15(1):11-8
pubmed: 15686620
Arthritis Rheum. 2010 Jun;62(6):1650-9
pubmed: 20178133
J Neurosci. 1996 Apr 15;16(8):2716-23
pubmed: 8786447
Spine (Phila Pa 1976). 2001 Sep 1;26(17):1873-8
pubmed: 11568697
Nature. 2001 Mar 1;410(6824):37-40
pubmed: 11242034
Nat Rev Cancer. 2009 Aug;9(8):537-49
pubmed: 19629069
Rheumatology (Oxford). 2008 Apr;47(4):409-14
pubmed: 18187523
Eur Spine J. 2012 Oct;21(10):2079-84
pubmed: 22350007
Curr Opin Cell Biol. 2000 Apr;12(2):186-92
pubmed: 10712927
Biochim Biophys Acta. 2007 Aug;1773(8):1358-75
pubmed: 17481747
Spine (Phila Pa 1976). 1995 Sep 1;20(17):1878-83
pubmed: 8560335
Spine (Phila Pa 1976). 2007 Mar 15;32(6):635-42
pubmed: 17413467
Prostaglandins Other Lipid Mediat. 2021 Jun;154:106550
pubmed: 33857603
Arthritis Res Ther. 2007;9(4):R77
pubmed: 17688691
Biochem Soc Trans. 2006 Dec;34(Pt 6):1018-23
pubmed: 17073741
Cell Mol Life Sci. 2013 Jan;70(2):223-37
pubmed: 22695679
J Neurosci. 2003 Apr 1;23(7):2517-21
pubmed: 12684435
Eur Spine J. 2013 Apr;22(4):794-801
pubmed: 23090093
Exp Neurol. 2003 Dec;184(2):606-14
pubmed: 14769353
Spine (Phila Pa 1976). 2003 Dec 15;28(24):2685-93
pubmed: 14673370
Brain Res. 2004 Jun 11;1011(1):1-6
pubmed: 15140639

Auteurs

Takuya Kusakabe (T)

Department of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Yasunobu Sawaji (Y)

Department of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
ORCID: 0000-0002-2692-0126

Kenji Endo (K)

Department of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Hidekazu Suzuki (H)

Department of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
ORCID: 0000-0002-1556-1199

Takamitsu Konishi (T)

Department of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Asato Maekawa (A)

Department of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Kazuma Murata (K)

Department of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Kengo Yamamoto (K)

Department of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › DUSP-1 Induced by PGE
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › DUSP-1 Induced by PGE
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › DUSP-1 Induced by PGE
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Prostaglandines E › Alprostadil › DUSP-1 Induced by PGE
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Prostaglandines E › Dinoprostone › DUSP-1 Induced by PGE
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein Tyrosine Phosphatases › Dual-specificity phosphatases › Dual Specificity Phosphatase 1 › DUSP-1 Induced by PGE
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › DUSP-1 Induced by PGE
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Monokines › Interleukine-1 › Interleukine-1 bêta › DUSP-1 Induced by PGE
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › Fibrocartilage › Disque intervertébral › DUSP-1 Induced by PGE
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Système de signalisation des MAP kinases › DUSP-1 Induced by PGE
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › DUSP-1 Induced by PGE
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur de croissance nerveuse › DUSP-1 Induced by PGE
questionsmedicales.fr › Métabolisme › Phosphorylation › DUSP-1 Induced by PGE
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › DUSP-1 Induced by PGE
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › DUSP-1 Induced by PGE