TNFα Mediates Inflammation-Induced Effects on
3T3-L1 Cells
Adipose Tissue
/ pathology
Animals
Humans
Inflammation
/ genetics
Macrophages
/ metabolism
Mesenchymal Stem Cells
/ metabolism
Mice
Mice, Inbred C57BL
Middle Aged
Obesity
/ genetics
PPAR gamma
/ genetics
Phosphatidylinositol 3-Kinases
/ metabolism
Phosphorylation
Proto-Oncogene Proteins c-akt
/ metabolism
RNA Splicing
/ genetics
Serine-Arginine Splicing Factors
/ metabolism
Signal Transduction
THP-1 Cells
Tumor Necrosis Factor-alpha
/ adverse effects
PPARG splicing
TNFα
adipocyte precursors
dominant negative isoform
hypertrophic obesity
inflammation
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
24 12 2021
24 12 2021
Historique:
received:
10
08
2021
revised:
16
12
2021
accepted:
20
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Low-grade chronic inflammation and reduced differentiation capacity are hallmarks of hypertrophic adipose tissue (AT) and key contributors of insulin resistance. We identified PPARGΔ5 as a dominant-negative splicing isoform overexpressed in the AT of obese/diabetic patients able to impair adipocyte differentiation and PPARγ activity in hypertrophic adipocytes. Herein, we investigate the impact of macrophage-secreted pro-inflammatory factors on
Identifiants
pubmed: 35011604
pii: cells11010042
doi: 10.3390/cells11010042
pmc: PMC8750445
pii:
doi:
Substances chimiques
PPAR gamma
0
SRSF5 protein, human
0
Tumor Necrosis Factor-alpha
0
Serine-Arginine Splicing Factors
170974-22-8
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PON Ricerca e Innovazione 2014-2020, PON Ars01_01270 "Innovative Device For SHAping the Risk of Diabetes" (IDF SHARID)
Organisme : European Foundation for the Study of Diabetes
ID : Boehringer Ingelheim European Research Programme in Microvascular Complications of Diabetes
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