Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia.
Alcoholism
Anxiety Disorders
Attention Deficit Disorder with Hyperactivity
/ genetics
Case-Control Studies
Female
Genetic Predisposition to Disease
/ genetics
Genome-Wide Association Study
Humans
Loneliness
Male
Mendelian Randomization Analysis
Multifactorial Inheritance
Phenotype
Schizophrenia
/ genetics
Social Isolation
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 01 2022
10 01 2022
Historique:
received:
18
12
2020
accepted:
26
11
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
28
1
2022
Statut:
epublish
Résumé
Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control sample (N = 3,488). We then subset schizophrenia predisposing variation based on its effect on LNL-ISO. We find that genetic variation with concordant effects in both phenotypes shows significant SNP-based heritability enrichment, higher polygenic contribution in females, and positive covariance with mental disorders such as depression, anxiety, attention-deficit hyperactivity disorder, alcohol dependence, and autism. Conversely, genetic variation with discordant effects only contributes to schizophrenia risk in males and is negatively correlated with those disorders. Mendelian randomization analyses demonstrate a plausible bi-directional causal relationship between LNL-ISO and schizophrenia, with a greater effect of LNL-ISO liability on schizophrenia than vice versa. These results illustrate the genetic footprint of LNL-ISO on schizophrenia.
Identifiants
pubmed: 35013163
doi: 10.1038/s41467-021-27598-6
pii: 10.1038/s41467-021-27598-6
pmc: PMC8748758
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
51Informations de copyright
© 2022. The Author(s).
Références
Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5797-801
pubmed: 23530191
Epidemiol Rev. 2008;30:67-76
pubmed: 18480098
Soc Psychiatry Psychiatr Epidemiol. 2020 Feb;55(2):251-257
pubmed: 31115597
Psychol Bull. 1995 May;117(3):497-529
pubmed: 7777651
Am J Hum Genet. 2019 Aug 1;105(2):334-350
pubmed: 31374203
Aging Ment Health. 2004 Nov;8(6):475-85
pubmed: 15724829
Int Rev Psychiatry. 2019 Aug - Sep;31(5-6):471-490
pubmed: 31331209
Genet Epidemiol. 2016 May;40(4):304-14
pubmed: 27061298
BMC Psychiatry. 2017 Mar 20;17(1):97
pubmed: 28320380
Am J Hum Genet. 2018 Jun 7;102(6):1185-1194
pubmed: 29754766
Psychol Med. 2019 Jan;49(2):268-277
pubmed: 29684289
Ann N Y Acad Sci. 2011 Aug;1231:17-22
pubmed: 21651565
PLoS One. 2018 Mar 22;13(3):e0194021
pubmed: 29566046
J Gen Intern Med. 2014 Nov;29(11):1429-31
pubmed: 25092012
Soc Psychiatry Psychiatr Epidemiol. 2013 Jan;48(1):5-13
pubmed: 22570258
Psychiatry Res. 2017 Jan;247:345-351
pubmed: 27987484
Schizophr Res. 2010 Sep;122(1-3):193-8
pubmed: 20842798
Res Aging. 2004;26(6):655-672
pubmed: 18504506
BMC Psychiatry. 2020 Apr 5;20(1):149
pubmed: 32248839
Psychiatr Prax. 1985 May;12(3):104-6
pubmed: 4023115
Neuropsychopharmacology. 2019 Aug;44(9):1562-1569
pubmed: 31078131
Int J Epidemiol. 2017 Dec 1;46(6):1985-1998
pubmed: 29040600
Nat Genet. 2015 Mar;47(3):291-5
pubmed: 25642630
Nat Genet. 2015 Nov;47(11):1236-41
pubmed: 26414676
Elife. 2018 May 30;7:
pubmed: 29846171
Soc Psychiatry Psychiatr Epidemiol. 2016 Mar;51(3):339-48
pubmed: 26843197
Nat Commun. 2019 Jan 18;10(1):333
pubmed: 30659178
Br J Psychiatry Suppl. 1994 Apr;(23):29-38
pubmed: 8037899
J Affect Disord. 2015 Aug 15;182:26-31
pubmed: 25965692
Neuropharmacology. 2019 Jun;151:45-54
pubmed: 30935859
Am J Hum Genet. 2017 Dec 7;101(6):939-964
pubmed: 29220677
Ann Behav Med. 2010 Oct;40(2):218-27
pubmed: 20652462
Eur Psychiatry. 2012 Aug;27(6):406-8
pubmed: 21616645
J Neurosci. 2008 Jan 2;28(1):264-78
pubmed: 18171944
Nature. 2014 Jul 24;511(7510):421-7
pubmed: 25056061
Schizophr Bull. 2018 Feb 15;44(2):242-249
pubmed: 28637195
Schizophr Bull. 2017 May 1;43(3):654-664
pubmed: 27338279
Compr Psychiatry. 2017 Apr;74:35-43
pubmed: 28092774
Psychiatry Res. 2018 May;263:101-107
pubmed: 29524907
Mol Psychiatry. 2020 Apr;25(4):703-705
pubmed: 30610204
Psychol Aging. 2006 Mar;21(1):140-51
pubmed: 16594799
Int J Epidemiol. 2015 Apr;44(2):512-25
pubmed: 26050253
Nat Genet. 2018 May;50(5):693-698
pubmed: 29686387
Arch Womens Ment Health. 2018 Dec;21(6):627-648
pubmed: 29766281
Nat Rev Neurosci. 2017 Jun;18(6):335-346
pubmed: 28469276
Acta Psychiatr Scand. 2018 Sep;138(3):253-266
pubmed: 29984409
Psychol Med. 2020 Sep;50(12):1949-1965
pubmed: 32684198
Hum Mol Genet. 2014 Sep 15;23(R1):R89-98
pubmed: 25064373
J Pers Assess. 1996 Feb;66(1):20-40
pubmed: 8576833
Schizophr Bull. 2018 Oct 17;44(6):1195-1203
pubmed: 29762765
Genet Epidemiol. 2018 Dec;42(8):783-795
pubmed: 30251275
Schizophr Bull. 2013 Nov;39(6):1180-6
pubmed: 24062592
Nat Genet. 2015 Nov;47(11):1228-35
pubmed: 26414678
Nat Genet. 2018 Mar;50(3):381-389
pubmed: 29483656
World Psychiatry. 2020 Oct;19(3):350-359
pubmed: 32931100
Nat Commun. 2020 Dec 15;11(1):6393
pubmed: 33319780
Nat Genet. 2020 Jul;52(7):740-747
pubmed: 32451458
Am J Epidemiol. 2017 Nov 1;186(9):1026-1034
pubmed: 28641372
Hum Mol Genet. 2019 Nov 15;28(22):3853-3865
pubmed: 31518406
J Child Psychol Psychiatry. 2014 Oct;55(10):1068-87
pubmed: 25132410
Psychosom Med. 2013 Feb;75(2):161-70
pubmed: 23362501
Annu Rev Psychol. 2015 Jan 3;66:733-67
pubmed: 25148851
Eur Child Adolesc Psychiatry. 2020 Jul;29(7):1003-1010
pubmed: 31595438
Soc Psychiatry Psychiatr Epidemiol. 2019 Nov;54(11):1343-1351
pubmed: 31456027
Soc Psychiatry Psychiatr Epidemiol. 2018 Mar;53(3):221-238
pubmed: 29327166
Wellcome Open Res. 2019 Nov 26;4:186
pubmed: 32760811
Schizophr Res. 2015 Dec;169(1-3):268-273
pubmed: 26527247
Schizophr Bull. 2018 Jan 13;44(1):114-125
pubmed: 28369646
Genome Biol. 2021 Sep 7;22(1):262
pubmed: 34493297
J Pers Soc Psychol. 1986 Nov;51(5):1069-74
pubmed: 3794995
Nat Genet. 2018 Feb;50(2):229-237
pubmed: 29292387
Schizophr Bull. 2006 Oct;32(4):592-8
pubmed: 16849399
Arch Gen Psychiatry. 2007 Jan;64(1):19-28
pubmed: 17199051
Genet Epidemiol. 2012 Apr;36(3):214-24
pubmed: 22714935
Nat Commun. 2018 Jul 3;9(1):2457
pubmed: 29970889
Nat Genet. 2018 Apr;50(4):621-629
pubmed: 29632380
Neuropsychopharmacology. 2017 Mar;42(4):811-821
pubmed: 27629369
J Affect Disord. 2020 Jun 15;271:131-138
pubmed: 32479308
Genes Brain Behav. 2018 Jul;17(6):e12472
pubmed: 29573219
Hippocampus. 2018 Sep;28(9):672-679
pubmed: 28843041
Clin Psychol Rev. 2006 Oct;26(6):695-718
pubmed: 16952717
Early Interv Psychiatry. 2018 Dec;12(6):1157-1165
pubmed: 28524542
Perspect Psychol Sci. 2015 Mar;10(2):227-37
pubmed: 25910392
Schizophr Res Treatment. 2012;2012:916198
pubmed: 22966451
J Abnorm Psychol. 1985 Aug;94(3):384-96
pubmed: 4031235
Nat Hum Behav. 2019 May;3(5):513-525
pubmed: 30962613
Am J Psychiatry. 1995 May;152(5):698-703
pubmed: 7726309
PLoS One. 2013;8(2):e55851
pubmed: 23405221