[
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
10 01 2022
10 01 2022
Historique:
received:
31
07
2021
accepted:
07
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
19
2
2022
Statut:
epublish
Résumé
Hyperpolarized [1-
Identifiants
pubmed: 35013537
doi: 10.1038/s42003-021-02978-2
pii: 10.1038/s42003-021-02978-2
pmc: PMC8748681
doi:
Substances chimiques
Bicarbonates
0
Biomarkers
0
Pyruvic Acid
8558G7RUTR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10Subventions
Organisme : EC | EC Seventh Framework Programm | FP7 People: Marie-Curie Actions (FP7-PEOPLE - Specific Programme "People" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013))
ID : 264780
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)
ID : PP00P2_133562
Organisme : European Research Council
ID : 682574
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)
ID : PZ00P3_167871
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : 682574
Organisme : Cancer Research UK (CRUK)
ID : A29580
Informations de copyright
© 2022. The Author(s).
Références
Owen, O. E., Kalhan, S. C. & Hanson, R. W. The key role of anaplerosis and cataplerosis for citric acid cycle function. J. Biol. Chem. 277, 30409–30412 (2002).
pubmed: 12087111
doi: 10.1074/jbc.R200006200
Stark, R. et al. A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis. J. Biol. Chem. 289, 7257–7263 (2014).
pubmed: 24497630
pmcid: 3953244
doi: 10.1074/jbc.C113.544759
Koliaki, C. et al. Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab. 21, 739–746 (2015).
pubmed: 25955209
doi: 10.1016/j.cmet.2015.04.004
Magnusson, I., Rothman, D. L., Katz, L. D., Shulman, R. G. & Shulman, G. I. Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. J. Clin. Invest. 90, 1323–1327 (1992).
pubmed: 1401068
pmcid: 443176
doi: 10.1172/JCI115997
Moreira, C. C. et al. Changes in liver gluconeogenesis during the development of Walker-256 tumour in rats. Int J. Exp. Pathol. 94, 47–55 (2013).
pubmed: 23317353
pmcid: 3575873
doi: 10.1111/iep.12002
Satapati, S. et al. Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver. J. Lipid Res. 53, 1080–1092 (2012).
Rines, A. K., Sharabi, K., Tavares, C. D. & Puigserver, P. Targeting hepatic glucose metabolism in the treatment of type 2 diabetes. Nat. Rev. Drug Discov. 15, 786–804 (2016).
pubmed: 27516169
pmcid: 5751421
doi: 10.1038/nrd.2016.151
Jin, E. S. et al. Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative. Anal. Biochem. 327, 149–155 (2004).
pubmed: 15051530
doi: 10.1016/j.ab.2003.12.036
Jones, J. G. et al. Measurement of gluconeogenesis and pyruvate recycling in the rat liver: a simple analysis of glucose and glutamate isotopomers during metabolism of [1,2,3-13C3]propionate. FEBS Lett. 412, 131–137 (1997).
Browning, J. D. et al. Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction. Hepatology 48, 1487–1496 (2008).
pubmed: 18925642
doi: 10.1002/hep.22504
Burgess, S. C. et al. Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine. Anal. Biochem. 312, 228–234 (2003).
pubmed: 12531210
doi: 10.1016/S0003-2697(02)00465-7
Jones, J. G., Solomon, M. A., Cole, S. M., Sherry, A. D. & Malloy, C. R. An integrated 2H and 13C NMR study of gluconeogenesis and TCA cycle flux in humans. Am. J. Physiol. 281, E848–E856 (2001).
Befroy, D. E. et al. Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy. Nat. Med. 20, 98–102 (2014).
pubmed: 24317120
doi: 10.1038/nm.3415
Comment, A. & Merritt, M. E. Hyperpolarized magnetic resonance as a sensitive detector of metabolic function. Biochemistry 53, 7333–7357 (2014).
pubmed: 25369537
doi: 10.1021/bi501225t
Marco-Rius, I. & Comment, A. in eMagRes (ed. Harris, R. K. & Wasylishen, R. L.) 167–178 (2018).
Nelson, S. J. et al. Metabolic imaging of patients with prostate cancer using hyperpolarized [1-13C]Pyruvate. Sci. Transl. Med. 5, 198ra108 (2013).
pubmed: 23946197
pmcid: 4201045
doi: 10.1126/scitranslmed.3006070
Merritt, M. E., Harrison, C., Sherry, A. D., Malloy, C. R. & Burgess, S. C. Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance. Proc. Natl Acad. Sci. USA 108, 19084–19089 (2011).
pubmed: 22065779
pmcid: 3223470
doi: 10.1073/pnas.1111247108
Jin, E. S. et al. Metabolism of hyperpolarized [1-(13)C]pyruvate through alternate pathways in rat liver. NMR Biomed. 29, 466–474 (2016).
Faarkrog Hoyer, K. et al. Assessment of mouse liver [1-13C]pyruvate metabolism by dynamic hyperpolarized MRS. J. Endocrinol. 242, 251–260 (2019).
pubmed: 31311004
doi: 10.1530/JOE-19-0159
Lee, P. et al. In Vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model. Hepatology 57, 515–524 (2013).
pubmed: 22911492
doi: 10.1002/hep.26028
von Morze, C. et al. Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13C-lactate and 13C-pyruvate in kidney and liver. Magn. Reson. Med. 77, 1429–1437 (2017).
doi: 10.1002/mrm.26245
Sharma, P., Walsh, K. T., Kerr-Knott, K. A., Karaian, J. E. & Mongan, P. D. Pyruvate modulates hepatic mitochondrial functions and reduces apoptosis indicators during hemorrhagic shock in rats. Anesthesiology 103, 65–73 (2005).
pubmed: 15983458
doi: 10.1097/00000542-200507000-00013
Shaghaghi, H. et al. Ascorbic acid prolongs the viability and stability of isolated perfused lungs: A mechanistic study using P-31 and hyperpolarized C-13 nuclear magnetic resonance. Free Rad. Biol. Med. 89, 62–71 (2015).
pubmed: 26165188
doi: 10.1016/j.freeradbiomed.2015.06.042
Yoshihara, H. A., Bastiaansen, J. A., Berthonneche, C., Comment, A. & Schwitter, J. An intact small animal model of myocardial ischemia-reperfusion: characterization of metabolic changes by hyperpolarized 13C MR spectroscopy. Am. J. Physiol. Heart Circ. Physiol. 309, H2058–H2066 (2015).
pubmed: 26453328
doi: 10.1152/ajpheart.00376.2015
Hu, S. et al. In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate. Mol. Imaging Biol. 11, 399–407 (2009).
pubmed: 19424761
pmcid: 2763080
doi: 10.1007/s11307-009-0218-z
Zierhut, M. L. et al. Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice. J. Magn. Reson. 202, 85–92 (2010).
pubmed: 19884027
doi: 10.1016/j.jmr.2009.10.003
Bastiaansen, J. A. M. et al. In vivo enzymatic activity of acetylCoA synthetase in skeletal muscle revealed by C-13 turnover from hyperpolarized [1-C-13]acetate to [1-C-13]acetylcarnitine. Biochim. Biophys. Acta Gen. Subj. 1830, 4171–4178 (2013).
doi: 10.1016/j.bbagen.2013.03.023
Janich, M. A. et al. Effects of pyruvate dose on in vivo metabolism and quantification of hyperpolarized 13C spectra. NMR Biomed. 25, 142–151 (2012).
pubmed: 21823181
doi: 10.1002/nbm.1726
Williamson, D. H., Lopes-Vieira, O. & Walker, B. Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses. Biochem. J. 104, 497–502 (1967).
pubmed: 6048791
pmcid: 1270611
doi: 10.1042/bj1040497
Behal, R. H., Buxton, D. B., Robertson, J. G. & Olson, M. S. Regulation of the pyruvate dehydrogenase multienzyme complex. Annu. Rev. Nutr. 13, 497–520 (1993).
pubmed: 8369156
doi: 10.1146/annurev.nu.13.070193.002433
Dennis, S. C., DeBuysere, M., Scholz, R. & Olson, M. S. Studies on the relationship between ketogenesis and pyruvate oxidation in isolated rat liver mitochondria. J. Biol. Chem. 253, 2229–2237 (1978).
pubmed: 632266
doi: 10.1016/S0021-9258(17)38063-8
Ponsot, E. et al. Mitochondrial tissue specificity of substrates utilization in rat cardiac and skeletal muscles. J. Cell Physiol. 203, 479–486 (2005).
pubmed: 15521069
doi: 10.1002/jcp.20245
Rao, Y. et al. Hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane. Proc. Natl Acad. Sci. USA 117, 22378–22389 (2020).
pubmed: 32839325
pmcid: 7486767
doi: 10.1073/pnas.2003537117
Chen, J., Hackett, E. P., Kovacs, Z., Malloy, C. R. & Park, J. M. Assessment of hepatic pyruvate carboxylase activity using hyperpolarized [1-13C]-L-lactate. Magn. Reson. Med. 85, 1175–1182 (2021).
pubmed: 32936474
doi: 10.1002/mrm.28489
DiTullio, N. W. et al. 3-mercaptopicolinic acid, an inhibitor of gluconeogenesis. Biochem. J. 138, 387–394 (1974).
pubmed: 4429541
pmcid: 1166224
doi: 10.1042/bj1380387
Burt, M. E. et al. Hypoglycemia with glycerol infusion as antineoplastic therapy: a hypothesis. Surgery 97, 231–233 (1985).
pubmed: 3969626
She, P. et al. Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol. Cell Biol. 20, 6508–6517 (2000).
pubmed: 10938127
pmcid: 86125
doi: 10.1128/MCB.20.17.6508-6517.2000
Vinay, P., Coutlee, F., Martel, P., Lemieux, G. & Gougoux, A. Effect of phosphoenolpyruvate carboxykinase inhibition on renal metabolism of glutamine: in vivo studies in the dog and rat. Can. J. Biochem. 58, 103–111 (1980).
pubmed: 7388677
doi: 10.1139/o80-015
Scrutton, M. C. & White, M. D. Pyruvate carboxylase. Inhibition of the mammalian and avian liver enzymes by alpha-ketoglutarate and L-glutamate. J. Biol. Chem. 249, 5405–5415 (1974).
pubmed: 4415414
doi: 10.1016/S0021-9258(20)79742-5
Moreno, K. X. et al. Production of hyperpolarized 13CO2 from [1-13C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production. Metabolomics 11, 1144–1156 (2015).
pubmed: 26543443
pmcid: 4629494
doi: 10.1007/s11306-014-0768-1
Perry, R. J. et al. Propionate increases hepatic pyruvate cycling and anaplerosis and alters mitochondrial metabolism. J. Biol. Chem. 291, 12161–12170 (2016).
pubmed: 27002151
pmcid: 4933266
doi: 10.1074/jbc.M116.720631
Hui, S. et al. Quantitative fluxomics of circulating metabolites. Cell Metab. 32, 676–688 (2020).
pubmed: 32791100
pmcid: 7544659
doi: 10.1016/j.cmet.2020.07.013
Cornell, N. W., Schramm, V. L., Kerich, M. J. & Emig, F. A. Subcellular location of phosphoenolpyruvate carboxykinase in hepatocytes from fed and starved rats. J. Nutr. 116, 1101–1108 (1986).
pubmed: 3723205
doi: 10.1093/jn/116.6.1101
Nordlie, R. C. & Lardy, H. A. Mammalian liver phosphoneolpyruvate carboxykinase activities. J. Biol. Chem. 238, 2259–2263 (1963).
pubmed: 13938894
doi: 10.1016/S0021-9258(19)67962-7
Saggerson, D. & Evans, C. J. The activities and intracellular distribution of nicotinamide-adenine dinucleotide phosphate-malate dehydrogenase, phosphoenolpyruvate carboxykinase and pyruvate carboxylase in rat, guinea-pig and rabbit tissues. Biochem. J. 146, 329–332 (1975).
pubmed: 239692
pmcid: 1165309
doi: 10.1042/bj1460329
Amoedo, N. D. et al. AGC1/2, the mitochondrial aspartate-glutamate carriers. Biochim. Biophys. Acta 1863, 2394–2412 (2016).
pubmed: 27132995
doi: 10.1016/j.bbamcr.2016.04.011
Bowes, T., Singh, B. & Gupta, R. S. Subcellular localization of fumarase in mammalian cells and tissues. Histochem Cell Biol. 127, 335–346 (2007).
pubmed: 17111171
doi: 10.1007/s00418-006-0249-3
Shchepin, R. V., Coffey, A. M., Waddell, K. W. & Chekmenev, E. Y. PASADENA hyperpolarized 13C phospholactate. J. Am. Chem. Soc. 134, 3957–3960 (2012).
pubmed: 22352377
pmcid: 3318994
doi: 10.1021/ja210639c
Larson, P. E. Z. et al. Multiband excitation pulses for hyperpolarized C-13 dynamic chemical-shift imaging. J. Magn. Reson. 194, 121–127 (2008).
pubmed: 18619875
pmcid: 3739981
doi: 10.1016/j.jmr.2008.06.010
Cunningham, C. H. et al. Hyperpolarized 13C metabolic MRI of the human heart: initial experience. Circ. Res. 119, 1177–1182 (2016).
pubmed: 27635086
pmcid: 5102279
doi: 10.1161/CIRCRESAHA.116.309769
Grist, J. T. et al. Quantifying normal human brain metabolism using hyperpolarized [1-13C]pyruvate and magnetic resonance imaging. Neuroimage 189, 171–179 (2019).
pubmed: 30639333
doi: 10.1016/j.neuroimage.2019.01.027
Cheng, T., Capozzi, A., Takado, Y., Balzan, R. & Comment, A. Over 35% liquid-state 13C polarization obtained via dissolution dynamic nuclear polarization at 7 T and 1 K using ubiquitous nitroxyl radicals. Phys. Chem. Chem. Phys. 15, 20819–20822 (2013).
pubmed: 24217111
doi: 10.1039/c3cp53022a
Yoshihara, H. A. I. et al. High-field dissolution dynamic nuclear polarization of [1-13C]pyruvic acid. Phys. Chem. Chem. Phys. 18, 12409–12413 (2016).
pubmed: 27093499
doi: 10.1039/C6CP00589F
Cheng, T. et al. Automated transfer and injection of hyperpolarized molecules with polarization measurement prior to in vivo NMR. NMR Biomed. 26, 1582–1588 (2013).
pubmed: 23893539
doi: 10.1002/nbm.2993
Comment, A. et al. Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner. Concepts Magn. Reson. 31B, 255–269 (2007).
doi: 10.1002/cmr.b.20099
Lee, H. B. & Blaufox, M. D. Blood volume in the rat. J. Nucl. Med. 26, 72–76 (1985).
pubmed: 3965655
Stasinopoulos, M., Rigby, R., Heller, G., Voudouris, V. & De Bastiani, F. Flexible Regression and Smoothing 1st edn. (Chapman and Hall/CRC, 2017).