Prenatal diagnosis of fetal growth restriction with polyhydramnios, etiology and impact on postnatal outcome.
Abortion, Induced
Female
Fetal Death
Fetal Growth Retardation
/ diagnosis
Humans
Infant, Newborn
Live Birth
Male
Perinatal Death
Polyhydramnios
/ diagnosis
Predictive Value of Tests
Pregnancy
Prognosis
Retrospective Studies
Risk Assessment
Risk Factors
Ultrasonography, Doppler
Ultrasonography, Prenatal
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 01 2022
10 01 2022
Historique:
received:
06
06
2021
accepted:
13
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
23
2
2022
Statut:
epublish
Résumé
To assess the spectrum of different etiologies, the intrauterine course, outcome and possible prognostic markers in prenatally detected fetal growth restriction (FGR) combined with polyhydramnios. Retrospective study of 153 cases with FGR combined with Polyhydramnios diagnosed by prenatal ultrasound over a period of 17 years. Charts were reviewed for ultrasound findings, prenatal and postnatal outcome. All cases were categorized into etiological groups and examined for differences. Five etiological groups were identified: chromosomal anomalies (n = 64, 41.8%), complex malformation syndromes (n = 37, 24.1%), isolated malformations (n = 24, 15.7%), musculoskeletal disorders (n = 14, 9.2%) and prenatal non-anomalous fetuses (n = 14, 9.2%). Subgroups showed significant disparities in initial diagnosis of combination of both pathologies, Ratio AFI/ gestational weeks and Doppler ultrasound examinations. Overall mortality rate was 64.7%. Fetuses prenatally assigned to be non-anomalous, showed further complications in 42.9% (n = 6). Fetuses prenatally diagnosed with FGR combined with polyhydramnios are affected by a high morbidity and mortality. Five etiologic groups can be differentiated, showing significant disparities in prenatal and postnatal outcome. Even without recognizable patterns prenatally, long-term-follow up is necessary, as neurodevelopmental or growth delay may occur.
Identifiants
pubmed: 35013541
doi: 10.1038/s41598-021-04371-9
pii: 10.1038/s41598-021-04371-9
pmc: PMC8748543
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
415Informations de copyright
© 2022. The Author(s).
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