Left ventricular contractile reserve as a determinant of adverse clinical outcomes: a systematic review.
adverse outcome
clinical outcome
contractile reserve
echocardiography
left ventricular contractile response to stress
Journal
Internal medicine journal
ISSN: 1445-5994
Titre abrégé: Intern Med J
Pays: Australia
ID NLM: 101092952
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
revised:
02
07
2020
received:
16
02
2020
accepted:
10
07
2020
pubmed:
12
1
2022
medline:
18
3
2022
entrez:
11
1
2022
Statut:
ppublish
Résumé
An abnormal left ventricular contractile reserve is often seen in patients undergoing stress echocardiogram and may indicate the presence of obstructive coronary artery disease. The techniques and indexes used to identify abnormal left ventricular contractile response and its prognostic value in the absence of known causes has not been well studied. To describe the characteristics and clinical outcomes associated with an abnormal left ventricular contractile response, we performed a systematic review that identified 27 eligible studies. A diverse range of indices were utilised to measure left ventricular contractile reserve, most commonly Δleft ventricular ejection fraction in 11 studies. Dobutamine stress echocardiogram was the most commonly performed modality (19 studies) followed by exercise stress echocardiogram (4 studies), dipyridamole stress echocardiogram (2 studies), invasive hemodynamic measurement (1 study) and dobutamine stress magnetic resonance imaging (1 study). All but one study demonstrated a significant association between the absence of left ventricular contractile reserve and increased rate of cardiovascular events, cardiac death and all-cause mortality.
Substances chimiques
Dobutamine
3S12J47372
Types de publication
Journal Article
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
186-197Informations de copyright
© 2022 Royal Australasian College of Physicians.
Références
Shah BN, Balaji G, Alhajiri A, Ramzy IS, Ahmadvazir S, Senior R. Incremental diagnostic and prognostic value of contemporary stress echocardiography in a chest pain unit: mortality and morbidity outcomes from a real-world setting. Circ Cardiovasc Imaging 2013; 6: 202-9.
Marwick TH. Stress echocardiography. Heart 2003; 89: 113-8.
Task Force M, Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C et al. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J 2013; 34: 2949-3003.
American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Society of Echocardiography, American Heart Association, American Society of Nuclear Cardiology, Heart Failure Society of America; Heart Rhythm Society et al. ACCF/ASE/AHA/ASNC/HFSA/HRS/SCAI/SCCM/SCCT/SCMR 2011 Appropriate Use Criteria for Echocardiography. A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Society of Echocardiography, American Heart Association, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Critical Care Medicine, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance American College of Chest Physicians. J Am Soc Echocardiogr 2011; 24: 229-67.
Paulsen WJ, DRB AF, Persaud JA. Ventricular response to isometric and isotonic exercise, echocardiographic assessment. Br Heart J 1979; 42: 521-7.
Armstrong WF, Zoghbi WA. Stress echocardiography: current methodology and clinical applications. J Am Coll Cardiol 2005; 45: 1739-47.
Tonino Bombardini MZ, Ciampi Q, Cortigiani L, Agricola E, Salvadori S, Loni T et al. Myocardial contractility in the stress echo lab: from pathophysiological toy to clinical tool. Cardiovasc Ultrasound 2013; 11: 41.
Holland DJ, Marwick TH, Haluska BA, Leano R, Hordern MD, Hare JL et al. Subclinical LV dysfunction and 10-year outcomes in type 2 diabetes mellitus. Heart 2015; 101: 1061-6.
Edwards NC, Hirth A, Ferro CJ, Townend JN, Steeds RP. Subclinical abnormalities of left ventricular myocardial deformation in early-stage chronic kidney disease: the precursor of uremic cardiomyopathy? J Am Soc Echocardiogr 2008; 21: 1293-8.
Nasis A, Moir S, Meredith IT, Barton TL, Nerlekar N, Wong DT et al. Abnormal left ventricular contractile response to exercise in the absence of obstructive coronary artery disease is associated with resting left ventricular long-axis dysfunction. J Am Soc Echocardiogr 2015; 28: 95-105.
Marwick TH. Application of stress echocardiography to the evaluation of non-coronary heart disease. Eur J Echocardiogr 2000; 1: 171-9.
Marwick TH. Accuracy and limitations of exercise echocardiography in a routine clinical setting. J Am Coll Cardiol 1992; 19: 74-81.
Marwick TH. Abnormal contractile reserve to exercise: a stress echocardiographic abnormality that may be associated with myocardial rather than coronary artery disease. J Am Soc Echocardiogr 2015; 28: 106-7.
Ha J-W, Juracan EM, Mahoney DW, Jae KO, Shub C, Seward JB et al. Hypertensive response to exercise: a potential cause for new wall motion abnormality in the absence of coronary artery disease. J Am Coll Cardiol 2002; 39: 323-7.
Gulli G, Cemin R, Pancera P, Menegatti G, Vassanelli C, Cevese A. Evidence of parasympathetic impairment in some patients with cardiac syndrome X. Cardiovasc Res 2001; 52: 208-16.
Lanza GA, Giordano A, Pristipino C, Calcagni ML, Meduri G, Trani C et al. Abnormal cardiac adrenergic nerve function in patients with syndrome X detected by (123I)metaiodobenzylguanidine myocardial scintigraphy. Circulation 1997; 96: 821-6.
From AM, Kane G, Bruce C, Pellikka PA, Scott C, RB MC. Characteristics and outcomes of patients with abnormal stress echocardiograms and angiographically mild coronary artery disease (<50% stenoses) or normal coronary arteries. J Am Soc Echocardiogr 2010; 23: 207-14.
David Moher AL, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses - the PRISMA statement. PLoS Med 2009; 6: 3.
Otasevic P, Popovic Z, Pratali L, Vlahovic A, Vasiljevic JD, Neskovic AN. Right vs. left ventricular contractile reserve in one-year prognosis of patients with idiopathic dilated cardiomyopathy: assessment by dobutamine stress echocardiography. Eur J Echocardiogr 2005; 6: 429-34.
Hideki Nagaoka NI, Kubota S, Lizuka T, Imai S, Suzuki T, Nagai R. Myocardial contractile reserve as prognostic determinant in patients with idiopathic dilated cardiomyopathy without overt heart failure. Chest 1997; 111: 344-50.
Ramahi TM, Longo MD, Cadariu AR, Rohlfs K, Slade M, Carolan S et al. Dobutamine-induced augmentation of left ventricular ejection fraction predicts survival of heart failure patients with severe non-ischaemic cardiomyopathy. Eur Heart J 2001; 22: 849-56.
Matsumoto K, Tanaka H, Onishi A, Motoji Y, Tatsumi K, Sawa T et al. Bi-ventricular contractile reserve offers an incremental prognostic value for patients with dilated cardiomyopathy. Eur Heart J Cardiovasc Imaging 2015; 16: 1213-23.
Rigo F, Gherardi S, Galderisi M, Sicari R, Picano E. The independent prognostic value of contractile and coronary flow reserve determined by dipyridamole stress echocardiography in patients with idiopathic dilated cardiomyopathy. Am J Cardiol 2007; 99: 1154-8.
Pratali L, Otasevic P, Rigo F, Gherardi S, Neskovic A, Picano E. The additive prognostic value of restrictive pattern and dipyridamole-induced contractile reserve in idiopathic dilated cardiomyopathy. Eur J Heart Fail 2005; 7: 844-51.
Marmor A, Schneeweiss A. Prognostic value of noninvasively obtained left ventricular contractile reserve in patients with severe heart failure. J Am Coll Cardiol 1997; 29: 422-8.
Matsumoto K, Tanaka H, Miyoshi T, Hiraishi M, Kaneko A, Fukuda Y et al. Dynamic left ventricular dyssynchrony assessed on 3-dimensional speckle-tracking area strain during dobutamine stress has a negative impact on cardiovascular events in patients with idiopathic dilated cardiomyopathy. Circ J 2013; 77: 1750-9.
Fougeres E, Tribouilloy C, Monchi M, Petit-Eisenmann H, Baleynaud S, Pasquet A et al. Outcomes of pseudo-severe aortic stenosis under conservative treatment. Eur Heart J 2012; 33: 2426-33.
Monin JL, Quere JP, Monchi M, Petit H, Baleynaud S, Chauvel C et al. Low-gradient aortic stenosis: operative risk stratification and predictors for long-term outcome: a multicenter study using dobutamine stress hemodynamics. Circulation 2003; 108: 319-24.
Clavel MA, Fuchs C, Burwash IG, Mundigler G, Dumesnil JG, Baumgartner H et al. Predictors of outcomes in low-flow, low-gradient aortic stenosis: results of the multicenter TOPAS Study. Circulation 2008; 118: S234-42.
Lee R, Haluska B, Leung DY, Case C, Mundy J, Marwick TH. Functional and prognostic implications of left ventricular contractile reserve in patients with asymptomatic severe mitral regurgitation. Heart 2005; 91: 1407-12.
Barbash IM, Minha S, Ben-Dor I, Dvir D, Magalhaes MA, Torguson R et al. Relation of preprocedural assessment of myocardial contractility reserve on outcomes of aortic stenosis patients with impaired left ventricular function undergoing transcatheter aortic valve implantation. Am J Cardiol 2014; 113: 1536-42.
Magne J, Mahjoub H, Dulgheru R, Pibarot P, Pierard LA, Lancellotti P. Left ventricular contractile reserve in asymptomatic primary mitral regurgitation. Eur Heart J 2014; 35: 1608-16.
Cigarroa CG, deFilippi CR, Brickner ME, Alvarez LG, Wait MA, Grayburn PA. Dobutamine stress echocardiography identifies hibernating myocardium and predicts recovery of left ventricular function after coronary revascularization. Circulation 1993; 88: 430-6.
Chaudhry FA, Tauke JT, Alessandrini RS, Vardi G, Parker MA, Bonow RO. Prognostic implications of myocardial contractile reserve in patients with coronary artery disease and left ventricular dysfunction. J Am Coll Cardiol 1999; 34: 730-8.
Jourdain P, Funck F, Fulla Y, Hagege A, Bellorini M, Guillard N et al. Myocardial contractile reserve under low doses of dobutamine and improvement of left ventricular ejection fraction with treatment by carvedilol. Eur J Heart Fail 2002; 4: 269-76.
Bax JJ, Poldermans D, Schinkel AF, Boersma E, Elhendy A, Maat A et al. Perfusion and contractile reserve in chronic dysfunctional myocardium: relation to functional outcome after surgical revascularization. Circulation 2002; 106(Suppl 1): I14-8.
Sawada S, Bapat A, Vaz D, Weksler J, Fineberg N, Greene A et al. Incremental value of myocardial viability for prediction of Long-Term prognosis in surgically revascularized patients with left ventricular dysfunction. J Am Coll Cardiol 2003; 42: 2099-105.
Kelle S, Roes SD, Klein C, Kokocinski T, de Roos A, Fleck E et al. Prognostic value of myocardial infarct size and contractile reserve using magnetic resonance imaging. J Am Coll Cardiol 2009; 54: 1770-7.
Wever-Pinzon O, Bangalore S, Romero J, Silva Enciso J, Chaudhry FA. Inotropic contractile reserve can risk-stratify patients with HIV cardiomyopathy: a dobutamine stress echocardiography study. JACC Cardiovasc Imaging 2011; 4: 1231-8.
Muto C, Gasparini M, Neja CP, Iacopino S, Davinelli M, Zanon F et al. Presence of left ventricular contractile reserve predicts midterm response to cardiac resynchronization therapy - results from the LOw dose DObutamine stress-echo test in cardiac resynchronization therapy (LODO-CRT) trial. Heart Rhythm 2010; 7: 1600-5.
Eichhorn EJ, Grayburn PA, Mayer SA, St John Sutton M, Appleton C, Plehn J et al. Myocardial contractile reserve by dobutamine stress echocardiography predicts improvement in ejection fraction with beta-blockade in patients with heart failure: the Beta-Blocker Evaluation of Survival Trial (BEST). Circulation 2003; 108: 2336-41.
Civelli M, Cardinale D, Martinoni A, Lamantia G, Colombo N, Colombo A et al. Early reduction in left ventricular contractile reserve detected by dobutamine stress echo predicts high-dose chemotherapy-induced cardiac toxicity. Int J Cardiol 2006; 111: 120-6.
Ha TH, Seo HS, Choo WJ, Choi J, Suh J, Cho YH et al. The effect of metabolic syndrome on myocardial contractile reserve during exercise in non-diabetic hypertensive subjects. J Cardiovasc Ultrasound 2011; 19: 176-82.
Acquatella H, Perez JE, Condado JA, Sanchez I. Limited myocardial contractile reserve and chronotropic incompetence in patients with chronic Chagas' disease: assessment by dobutamine stress echocardiography. J Am Coll Cardiol 1999; 33: 522-9.
Shizukuda Y, Bolan CD, Tripodi DJ, Yau YY, Smith KP, Sachdev V et al. Left ventricular systolic function during stress echocardiography exercise in subjects with asymptomatic hereditary hemochromatosis. Am J Cardiol 2006; 98: 694-8.
Okumura T, Murohara T. Contractile reserve in dilated cardiomyopathy. In: Milei J (ed.). Cardiomyopathies. London: IntechOpen; 2013.
Otasevic P, Popovic ZB, Vasiljevic JD, Pratali L, Vlahovic-Stipac A, Boskovic SD et al. Head-to-head comparison of indices of left ventricular contractile reserve assessed by high-dose dobutamine stress echocardiography in idiopathic dilated cardiomyopathy: five-year follow up. Heart 2006; 92:1253-8.
Kalam K, Otahal P, Marwick TH. Prognostic implications of global LV dysfunction: a systematic review and meta-analysis of global longitudinal strain and ejection fraction. Heart 2014; 100: 1673-80.
Mariotti E, Agostini A, Angelucci E, Lucarelli G, Sgarbi E, Picano E. Reduced left ventricular contractile reserve identified by low dose dobutamine echocardiography as an early marker of cardiac involvement in asymptomatic patients with thalassemia major. Echocardiography (Mount Kisco, NY) 1996; 13: 463-72.
Fearon WF, Low AF, Yong AS, McGeoch R, Berry C, Shah MG et al. Prognostic value of the index of microcirculatory resistance measured after primary percutaneous coronary intervention. Circulation 2013; 127: 2436-41.
Mangiacapra F, Peace AJ, Di Serafino L, Pyxaras SA, Bartunek J, Wyffels E et al. Intracoronary EnalaPrilat to reduce microvascular damage during percutaneous coronary intervention (ProMicro) study. J Am Coll Cardiol 2013; 61: 615-21.
Streiner DL, Norman GR. "Precision" and "accuracy": two terms that are neither. J Clin Epidemiol 2006; 59: 327-30.