Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans.

Adaptation, Physiological / genetics Amino Acid Sequence Animals Caenorhabditis elegans / drug effects Caenorhabditis elegans Proteins / genetics Caloric Restriction Eating / genetics Gene Expression Regulation Glucose / metabolism Glycerol / metabolism Glycerol-3-Phosphate O-Acyltransferase / genetics Glycerophosphates / metabolism Helminth Proteins / genetics Isoenzymes / genetics Longevity / genetics Osmolar Concentration Phosphoric Monoester Hydrolases / genetics Sequence Alignment Sequence Homology, Amino Acid Stearoyl-CoA Desaturase / genetics Stress, Physiological / genetics

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
11 01 2022
Historique:
received: 12 01 2021
accepted: 07 12 2021
entrez: 12 1 2022
pubmed: 13 1 2022
medline: 9 2 2022
Statut: epublish

Résumé

Metabolic stress due to nutrient excess and lipid accumulation is at the root of many age-associated disorders and the identification of therapeutic targets that mimic the beneficial effects of calorie restriction has clinical importance. Here, using C. elegans as a model organism, we study the roles of a recently discovered enzyme at the heart of metabolism in mammalian cells, glycerol-3-phosphate phosphatase (G3PP) (gene name Pgp) that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol. We identify three Pgp homologues in C. elegans (pgph) and demonstrate in vivo that their protein products have G3PP activity, essential for glycerol synthesis. We demonstrate that PGPH/G3PP regulates the adaptation to various stresses, in particular hyperosmolarity and glucotoxicity. Enhanced G3PP activity reduces fat accumulation, promotes healthy aging and acts as a calorie restriction mimetic at normal food intake without altering fertility. Thus, PGP/G3PP can be considered as a target for age-related metabolic disorders.

Identifiants

DOI: 10.1038/s41467-021-27803-6 PMID: 35017476 PMC: PMC8752807
pubmed: 35017476
doi: 10.1038/s41467-021-27803-6
pii: 10.1038/s41467-021-27803-6
pmc: PMC8752807
doi:

Substances chimiques

Caenorhabditis elegans Proteins 0
Glycerophosphates 0
Helminth Proteins 0
Isoenzymes 0
alpha-glycerophosphoric acid 9NTI6P3O4X
Stearoyl-CoA Desaturase EC 1.14.19.1
fat-6 protein, C elegans EC 1.14.19.1
Acl-6 protein, C elegans EC 2.3.1.15
Glycerol-3-Phosphate O-Acyltransferase EC 2.3.1.15
Phosphoric Monoester Hydrolases EC 3.1.3.2
glycerol-1-phosphatase EC 3.1.3.21
Glucose IY9XDZ35W2
Glycerol PDC6A3C0OX

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

177

Subventions

Organisme : CIHR
Pays : Canada

Informations de copyright

© 2022. The Author(s).

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Auteurs

Elite Possik (E)

Department of Nutrition, Université de Montréal, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.
Department of Biochemistry and Molecular Medicine, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.
ORCID: 0000-0003-1578-5819

Clémence Schmitt (C)

Department of Nutrition, Université de Montréal, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.
Department of Biochemistry and Molecular Medicine, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.
ORCID: 0000-0003-3434-7718

Anfal Al-Mass (A)

Department of Nutrition, Université de Montréal, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.
Department of Biochemistry and Molecular Medicine, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.
ORCID: 0000-0003-1558-4734

Ying Bai (Y)

Department of Nutrition, Université de Montréal, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.
Department of Biochemistry and Molecular Medicine, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.

Laurence Côté (L)

Department of Nutrition, Université de Montréal, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.
Department of Biochemistry and Molecular Medicine, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.
ORCID: 0000-0002-3674-4218

Johanne Morin (J)

Department of Nutrition, Université de Montréal, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.
Department of Biochemistry and Molecular Medicine, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.

Heidi Erb (H)

Department of Nutrition, Université de Montréal, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.
Department of Biochemistry and Molecular Medicine, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.

Abel Oppong (A)

Department of Nutrition, Université de Montréal, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.
Department of Biochemistry and Molecular Medicine, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.
ORCID: 0000-0002-8006-1537

Wahab Kahloan (W)

Department of Nutrition, Université de Montréal, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.
Department of Biochemistry and Molecular Medicine, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada.
ORCID: 0000-0003-2628-1149

J Alex Parker (JA)

Department of Neurosciences, CRCHUM, Montréal, Canada.
ORCID: 0000-0002-3333-2445

S R Murthy Madiraju (SRM)

Department of Nutrition, Université de Montréal, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada. s.r.murthy.madiraju.chum@ssss.gouv.qc.ca.
Department of Biochemistry and Molecular Medicine, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada. s.r.murthy.madiraju.chum@ssss.gouv.qc.ca.
ORCID: 0000-0002-2613-2074

Marc Prentki (M)

Department of Nutrition, Université de Montréal, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada. marc.prentki@umontreal.ca.
Department of Biochemistry and Molecular Medicine, Montreal Diabetes Research Center, CRCHUM, Montréal, Canada. marc.prentki@umontreal.ca.

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Classifications MeSH

questionsmedicales.fr › Phénomènes biologiques › Adaptation biologique › Adaptation physiologique › Phosphoglycolate phosphatase homologs act as...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Phosphoglycolate phosphatase homologs act as...
questionsmedicales.fr › Eucaryotes › Animaux › Phosphoglycolate phosphatase homologs act as...
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questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Protéines de Caenorhabditis elegans › Phosphoglycolate phosphatase homologs act as...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Ration calorique › Restriction calorique › Phosphoglycolate phosphatase homologs act as...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil buccodentaire et de l'appareil digestif › Phénomènes physiologiques de l'appareil digestif › Consommation alimentaire › Phosphoglycolate phosphatase homologs act as...
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questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Phosphoglycolate phosphatase homologs act as...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Phosphoglycolate phosphatase homologs act as...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Isoenzymes › Phosphoglycolate phosphatase homologs act as...
questionsmedicales.fr › Phénomènes physiologiques › Longévité › Phosphoglycolate phosphatase homologs act as...
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questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphoric monoester hydrolases › Phosphoglycolate phosphatase homologs act as...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Alignement de séquences › Phosphoglycolate phosphatase homologs act as...
questionsmedicales.fr › Phénomènes génétiques › Similitude de séquences › Similitude de séquences d'acides aminés › Phosphoglycolate phosphatase homologs act as...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Fatty acid desaturases › Acyl-(acyl-carrier-protein)desaturase › Phosphoglycolate phosphatase homologs act as...
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