Metabolic sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum.
AgRP
FED3
dopamine
fasting
medicine
motivation
mouse
neuroscience
photometry
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
12 01 2022
12 01 2022
Historique:
received:
30
07
2021
accepted:
11
01
2022
pubmed:
13
1
2022
medline:
25
2
2022
entrez:
12
1
2022
Statut:
epublish
Résumé
Agouti-related peptide (AgRP) neurons increase motivation for food, however, whether metabolic sensing of homeostatic state in AgRP neurons potentiates motivation by interacting with dopamine reward systems is unexplored. As a model of impaired metabolic-sensing, we used the AgRP-specific deletion of carnitine acetyltransferase (
Identifiants
pubmed: 35018884
doi: 10.7554/eLife.72668
pii: 72668
pmc: PMC8803314
doi:
pii:
Substances chimiques
Agouti-Related Protein
0
Agrp protein, mouse
0
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022, Reichenbach et al.
Déclaration de conflit d'intérêts
AR, RC, RS, SL, MM, HD, SR, FR, TS, MD, AM, JN, DS, RM, AK, CD, RB, ZA No competing interests declared
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