Reduction of CD8 T Cell Functionality but Not Inhibitory Capacity by Integrase Inhibitors.
CD8
antiretroviral agents
dolutegravir
human immunodeficiency virus
immune response
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
09 03 2022
09 03 2022
Historique:
pubmed:
13
1
2022
medline:
29
4
2022
entrez:
12
1
2022
Statut:
ppublish
Résumé
Although HIV-specific CD8 T cells are effective in controlling HIV infection, they fail to clear infection even in the presence of antiretroviral therapy (ART) and cure strategies such as "shock-and-kill." Little is known how ART is contributing to HIV-specific CD8 T cell function and the ability to clear HIV infection. Therefore, we first assessed the cytokine polyfunctionality and proliferation of CD8 T cells from ART-treated HIV+ individuals directly
Identifiants
pubmed: 35019724
doi: 10.1128/JVI.01730-21
pmc: PMC8906395
doi:
Substances chimiques
Anti-HIV Agents
0
HIV Integrase Inhibitors
0
Reverse Transcriptase Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0173021Références
Cell Rep. 2017 Dec 19;21(12):3458-3470
pubmed: 29262326
J Virus Erad. 2019 Jan 1;5(1):3-9
pubmed: 30800420
J Virol. 2005 Nov;79(21):13239-49
pubmed: 16227247
Medicine (Baltimore). 2016 Jul;95(30):e4429
pubmed: 27472741
J Int AIDS Soc. 2017 May 19;20(1):21171
pubmed: 28537062
PLoS Med. 2008 May 6;5(5):e100
pubmed: 18462013
Blood. 2011 Aug 25;118(8):2138-49
pubmed: 21734237
J Immunol. 2018 Dec 15;201(12):3546-3557
pubmed: 30446567
J Virol. 2007 Jul;81(14):7725-31
pubmed: 17494064
AIDS. 2010 May 15;24(8):1095-105
pubmed: 20400885
Cold Spring Harb Perspect Med. 2012 Apr;2(4):a007161
pubmed: 22474613
EBioMedicine. 2016 Jun;8:217-229
pubmed: 27428432
J Virol. 2003 Feb;77(3):2081-92
pubmed: 12525643
Curr Treat Options Infect Dis. 2019;11(4):372-387
pubmed: 33380904
J Virol. 2015 Oct;89(20):10176-89
pubmed: 26223643
Front Immunol. 2015 Oct 02;6:504
pubmed: 26483794
Obesity (Silver Spring). 2011 May;19(5):917-24
pubmed: 20885388
Immunology. 2011 Jun;133(2):190-6
pubmed: 21517838
Pathog Immun. 2016 Spring;1(1):68-106
pubmed: 27430032
Front Immunol. 2019 May 28;10:1168
pubmed: 31191539
Viral Immunol. 2017 Jan/Feb;30(1):3-12
pubmed: 27805477
J Virol. 2007 Nov;81(21):11749-57
pubmed: 17804505
PLoS Pathog. 2014 Nov 13;10(10):e1004473
pubmed: 25393648
Front Immunol. 2018 Jan 25;9:20
pubmed: 29422894
J Acquir Immune Defic Syndr. 2011 Mar 1;56(3):213-21
pubmed: 21079516
Nat Med. 2017 Nov;23(11):1271-1276
pubmed: 28967921
Antimicrob Agents Chemother. 2018 May 25;62(6):
pubmed: 29661866
Pharmacol Res. 2019 Jan;139:524-534
pubmed: 30366100
Int J Infect Dis. 2021 Sep;110:21-28
pubmed: 34273516
PLoS Pathog. 2018 Apr 13;14(4):e1006973
pubmed: 29652923
J Acquir Immune Defic Syndr. 2017 Dec 15;76(5):527-531
pubmed: 28825943
J Clin Invest. 2017 Aug 1;127(8):3126-3135
pubmed: 28714868
J Clin Invest. 2018 Feb 1;128(2):876-889
pubmed: 29355843
J Virol. 2014 Nov;88(21):12793-801
pubmed: 25165102
Am J Physiol Endocrinol Metab. 2010 Jan;298(1):E49-58
pubmed: 19887598
BMC Cancer. 2020 Jul 13;20(1):650
pubmed: 32660441
J Clin Invest. 2016 Feb;126(2):455-63
pubmed: 26731469
Curr Opin HIV AIDS. 2016 Sep;11(5):492-500
pubmed: 27254748
Blood. 2006 Jun 15;107(12):4781-9
pubmed: 16467198
Curr Opin Endocrinol Diabetes Obes. 2010 Oct;17(5):446-52
pubmed: 20585248
Methods Enzymol. 2014;542:125-49
pubmed: 24862264
Front Immunol. 2019 Feb 26;10:291
pubmed: 30863403
J Virol. 2020 Sep 15;94(19):
pubmed: 32669328
Front Immunol. 2018 Jun 22;9:1452
pubmed: 29988382
Sci Rep. 2017 Aug 10;7(1):7785
pubmed: 28798348
Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):5914-5919
pubmed: 30850527
Curr Opin Immunol. 2010 Jun;22(3):314-20
pubmed: 20189791
Mol Metab. 2015 Jul 15;4(9):631-42
pubmed: 26413469
J Virol. 2020 Apr 16;94(9):
pubmed: 32051267
Nat Immunol. 2015 Jun;16(6):584-9
pubmed: 25990814
Nat Med. 2015 Feb;21(2):132-9
pubmed: 25599132
Cell Host Microbe. 2018 Jan 10;23(1):14-26
pubmed: 29324227
Curr Opin HIV AIDS. 2016 Jul;11(4):409-16
pubmed: 27054280
JCI Insight. 2019 Jun 20;4(12):
pubmed: 31217351