Acute effects of ketamine on the pregenual anterior cingulate: linking spontaneous activation, functional connectivity, and glutamate metabolism.


Journal

European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030

Informations de publication

Date de publication:
Jun 2022
Historique:
received: 13 09 2021
accepted: 16 12 2021
pubmed: 13 1 2022
medline: 17 5 2022
entrez: 12 1 2022
Statut: ppublish

Résumé

Ketamine exerts its rapid antidepressant effects via modulation of the glutamatergic system. While numerous imaging studies have investigated the effects of ketamine on a functional macroscopic brain level, it remains unclear how altered glutamate metabolism and changes in brain function are linked. To shed light on this topic we here conducted a multimodal imaging study in healthy volunteers (N = 23) using resting state fMRI and proton (

Identifiants

pubmed: 35020021
doi: 10.1007/s00406-021-01377-2
pii: 10.1007/s00406-021-01377-2
pmc: PMC9095553
doi:

Substances chimiques

Glutamine 0RH81L854J
Glutamic Acid 3KX376GY7L
Ketamine 690G0D6V8H

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

703-714

Subventions

Organisme : European Commission
ID : H2020-634541

Informations de copyright

© 2022. The Author(s).

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Auteurs

Matti Gärtner (M)

MSB Medical School Berlin, Rüdesheimer Straße 50, 14197, Berlin, Germany. matti.gaertner@medicalschool-berlin.de.
Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany. matti.gaertner@medicalschool-berlin.de.

Anne Weigand (A)

MSB Medical School Berlin, Rüdesheimer Straße 50, 14197, Berlin, Germany.

Milan Scheidegger (M)

Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland.

Mick Lehmann (M)

Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland.

Patrik O Wyss (PO)

Department of Radiology, Swiss Paraplegic Centre, Nottwil, Switzerland.

Andreas Wunder (A)

Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach an der Riss, Germany.

Anke Henning (A)

Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, USA.

Simone Grimm (S)

MSB Medical School Berlin, Rüdesheimer Straße 50, 14197, Berlin, Germany.
Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland.

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