Ovarian Stiffness Is Significantly Increased in Polycystic Ovary Syndrome and Related With Anti-Mullerian Hormone: A Point Shear Wave Elastography Study.
Journal
Ultrasound quarterly
ISSN: 1536-0253
Titre abrégé: Ultrasound Q
Pays: United States
ID NLM: 8809459
Informations de publication
Date de publication:
10 Jan 2022
10 Jan 2022
Historique:
pubmed:
13
1
2022
medline:
8
3
2022
entrez:
12
1
2022
Statut:
epublish
Résumé
Parenchymal stiffness obtained by point shear-wave elastography (pSWE) in solid organs is used as a sign of damage in these organs. However, its clinical use and whether patients with polycystic ovary syndrome (PCOS) have increased ovarian tissue stiffness are still unclear. The aim of this study is to determine the parameters related to ovarian stiffness and whether there is an increase in ovarian stiffness in patients with PCOS compared with healthy controls. Forty-five women who were followed up regularly with the diagnosis of PCOS and 30 healthy controls similar to age and sex were included in this study. In addition to the routine follow-up parameters for PCOS, serum homeostatic model assessment of insulin resistance and anti-Mullerian hormone (AMH) levels were examined in all patients, and pSWE examination was performed with pelvic ultrasound (US) and ElastPQ technique. Serum dehydroepiandrosterone sulfate, luteinizing hormone/follicle-stimulating hormone, testosterone, homeostatic model assessment of insulin resistance, and AMH were higher in PCOS compared with healthy controls (P < 0.001). Right, left, and mean ovary stiffness and volumes were significantly higher in PCOS group than healthy controls (P < 0.001). Correlation analysis was performed between mean ovary stiffness and dehydroepiandrosterone sulfate, luteinizing hormone/follicle-stimulating hormone, testosterone, homeostatic model assessment, and AMH and ovary volumes (P < 0.01 for each one). In linear regression analysis, only AMH was found to be related to mean ovary stiffness (P < 0.001 and β = 0.734). Ovarian stiffness value obtained by ElastPQ technique and pSWE method increases in PCOS patients compared with healthy controls and is closely related to serum AMH levels. In patients with PCOS, in addition to the conventional US, ovarian stiffness measured by pSWE may be an auxiliary examination in the follow-up of the disease. However, it was concluded that the ovarian stiffness measurement obtained in our current study should be supported by studies involving more patients and the transvaginal US method.
Identifiants
pubmed: 35020692
doi: 10.1097/RUQ.0000000000000592
pii: 00013644-202203000-00014
doi:
Substances chimiques
Anti-Mullerian Hormone
80497-65-0
Luteinizing Hormone
9002-67-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
83-88Informations de copyright
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Rackow BW. Polycystic ovary syndrome in adolescents. Curr Opin Obstet Gynecol . 2012;24:281–287.
Fauser BC, Tarlatzis BC, Rebar RW, et al. Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-sponsored 3rd PCOS consensus workshop group. Fertil Steril . 2012;97:28–38.e25.
Azziz R, Marin C, Hoq L, et al. Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span. J Clin Endocrinol Metab . 2005;90:4650–4658.
Ehrmann DA. Polycystic ovary syndrome. N Engl J Med . 2005;352:1223–1236.
Vrbikova J, Hill M, Starka L, et al. The effects of long-term metformin treatment on adrenal and ovarian steroidogenesis in women with polycystic ovary syndrome. Eur J Endocrinol . 2001;144:619–628.
Yang S, Gu YY, Jing F, et al. The effect of statins on levels of dehydroepiandrosterone (DHEA) in women with polycystic ovary syndrome: a systematic review and Meta-analysis. Med Sci Monit . 2019;25:590–597.
Wiweko B, Indra I, Susanto C, et al. The correlation between serum AMH and HOMA-IR among PCOS phenotypes. BMC Res Notes . 2018;11:114. doi:10.1186/s13104-018-3207-y.
doi: 10.1186/s13104-018-3207-y
Orsino A, Van Eyk N, Hamilton J. Clinical features, investigations and management of adolescents with polycystic ovary syndrome. Paediatr Child Health . 2005;10:602–608.
Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod . 2004;19:41–47.
Sumbul HE, Koc AS, Gülümsek E. Renal cortical stiffness is markedly increased in pre-diabetes mellitus and associated with albuminuria. Singapore Med J . 2020;61:435–442. doi:10.11622/smedj.2019052.
doi: 10.11622/smedj.2019052
Demirtas AO, Koc AS, Sumbul HE, et al. Liver stiffness obtained by ElastPQ ultrasound shear wave elastography independently determines mean right atrial pressure. Abdom Radiol (NY) . 2019;44(9):3030–3039. doi:10.1007/s00261-019-02083-3.
doi: 10.1007/s00261-019-02083-3
Koc AS, Pekoz BC, Donmez Y, et al. Usability of Achilles tendon strain elastography for the diagnosis of coronary artery disease. J Med Ultrason (2001) . 2019;46(3):343–351. doi:10.1007/s10396-019-00931-9.
doi: 10.1007/s10396-019-00931-9
Bankir M, Sumbul HE, Koc AS, et al. Elastography detected solid organ stiffness increased in patients with acromegaly. Medicine (Baltimore) . 2019;98(3):e14212.
Ertekin E, Turan OD, Tuncyurek O. Is shear wave elastography relevant in the diagnosis of polycystic ovarian syndrome? Med Ultrason . 2019;21(2):158–162. doi:10.11152/mu-1849.
doi: 10.11152/mu-1849
Çiraci S, Tan S, Özcan AŞ, et al. Contribution of real-time elastography in diagnosis of polycystic ovary syndrome. Diagn Interv Radiol . 2015;21(2):118–122. doi:10.5152/dir.2014.14094.
doi: 10.5152/dir.2014.14094
Mutharasan P, Galdones E, Peñalver Bernabé B, et al. Evidence for chromosome 2p16.3 polycystic ovary syndrome susceptibility locus in affected women of European ancestry. J Clin Endocrinol Metab . 2013;98:E185–E190.
Senaldi L, Gopi RP, Milla S, et al. Is ultrasound useful in the diagnosis of adolescents with polycystic ovary syndrome? J Pediatr Endocrinol Metab . 2015;28(5–6):605–612. doi:10.1515/jpem-2014-0307.
doi: 10.1515/jpem-2014-0307
Sun L, Fu Q. Three-dimensional transrectal ultrasonography in adolescent patients with polycystic ovarian syndrome. Int J Gynaecol Obstet . 2007;98:34–38.
Panchal S, Nagori CB. Baseline scan and ultrasound diagnosis of PCOS. Donald School J Ultrasound Obstet Gynecol . 2012;6:290–299.
Shah B, Parnell L, Milla S, et al. Endometrial thickness, uterine, and ovarian ultrasonographic features in adolescents with polycystic ovarian syndrome. J Pediatr Adolesc Gynecol . 2010;23:146–152.
Pawelczak M, Kenigsberg L, Milla S, et al. Elevated serum anti-Mullerian hormone in adolescents with polycystic ovary syndrome: relationship to ultrasound features. J Pediatr Endocrinol Metab . 2012;25:983–989.
Silfen ME, Denburg MR, Manibo AM, et al. Early endocrine, metabolic, and sonographic characteristics of polycystic ovary syndrome (PCOS): comparison between nonobese and obese adolescents. J Clin Endocrinol Metab . 2003;88:4682–4688.
Battaglia C, Battaglia B, Morotti E, et al. Two- and three-dimensional sonographic and color Doppler techniques for diagnosis of polycystic ovary syndrome. The stromal/ovarian volume ratio as a new diagnostic criterion. J Ultrasound Med . 2012;31:1015–1024.
Villa P, Rossodivita A, Sagnella F, et al. Ovarian volume and gluco-insulinaemic markers in the diagnosis of PCOS during adolescence. Clin Endocrinol (Oxf) . 2013;78:285–290.
Rattansingh A, Amooshahi H, Menezes RJ, et al. Utility of shear-wave elastography to differentiate low from advanced degrees of liver fibrosis in patients with hepatitis C virus infection of native and transplant livers. J Clin Ultrasound . 2018;46:311–318.
Chen SH, Lai HC, Chiang IP, et al. Changes in liver stiffness measurement using acoustic radiation force impulse elastography after antiviral therapy in patients with chronic hepatitis C. PLoS One . 2018;13:e0190455.
Lee MS, Bae JM, Joo SK, et al. Prospective comparison among transient elastography, supersonic shear imaging, and ARFI imaging for predicting fibrosis in nonalcoholic fatty liver disease. PLoS One . 2017;12:e0188321.
Ahn SJ, Lee JM, Chang W, et al. Prospective validation of intra- and interobserver reproducibility of a new point shear wave elastographic technique for assessing liver stiffness in patients with chronic liver disease. Korean J Radiol . 2017;18:926–935.
Zhou F, Shi LB, Zhang SY. Ovarian fibrosis: a phenomenon of concern. Chin Med J (Engl) . 2017;130:365–371.
Miao ZL, Guo L, Wang YX, et al. The intervention effect of Rosiglitozone in ovarian fibrosis of PCOS rats. Biomed Environ Sci . 2012;25:46–52.
Takahashi N, Harada M, Hirota Y, et al. Activation of endoplasmic reticulum stress in granulosa cells from patients with polycystic ovary syndrome contributes to ovarian fibrosis. Sci Rep . 2017;7:10824.
Young JM, McNeilly AS. Theca: the forgotten cell of the ovarian follicle. Reproduction . 2010;140:489–504.