Subamniotic Hemorrhage, a Possible New Presentation of Fetal and Neonatal Alloimmune Thrombocytopenia.
Allo-antibodies
Fetal and neonatal alloimmune thrombocytopenia
Hematoma
Human platelet antigens-5b
Placenta
Subamniotic
Journal
Fetal diagnosis and therapy
ISSN: 1421-9964
Titre abrégé: Fetal Diagn Ther
Pays: Switzerland
ID NLM: 9107463
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
08
2021
accepted:
23
12
2021
pubmed:
13
1
2022
medline:
6
4
2022
entrez:
12
1
2022
Statut:
ppublish
Résumé
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare fetal disease in which maternal antibodies directed toward fetal human platelet antigens (HPA) are formed during pregnancy and cause fetal thrombocytopenia. The diagnosis FNAIT is suspected when a fetus or neonate presents with signs of bleeding. We describe a pregnancy complicated by a placental hematoma in the 20th week of gestation as the first manifestation of FNAIT. Further evaluation showed signs of germinal matrix hemorrhage and HPA-5b allo-antibodies. After the diagnosis, intravenous immunoglobulin was administered weekly and a healthy daughter was born at 37 weeks. Histopathological analysis revealed that the hematoma was caused by a subamniotic hemorrhage of fetal origin. A subamniotic hematoma appears to be the first manifestation of FNAIT.
Sections du résumé
BACKGROUND
BACKGROUND
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare fetal disease in which maternal antibodies directed toward fetal human platelet antigens (HPA) are formed during pregnancy and cause fetal thrombocytopenia. The diagnosis FNAIT is suspected when a fetus or neonate presents with signs of bleeding.
CASE
METHODS
We describe a pregnancy complicated by a placental hematoma in the 20th week of gestation as the first manifestation of FNAIT. Further evaluation showed signs of germinal matrix hemorrhage and HPA-5b allo-antibodies. After the diagnosis, intravenous immunoglobulin was administered weekly and a healthy daughter was born at 37 weeks. Histopathological analysis revealed that the hematoma was caused by a subamniotic hemorrhage of fetal origin.
CONCLUSION
CONCLUSIONS
A subamniotic hematoma appears to be the first manifestation of FNAIT.
Identifiants
pubmed: 35021176
pii: 000521866
doi: 10.1159/000521866
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
60-64Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2022 The Author(s). Published by S. Karger AG, Basel.