Endothelial Retargeting of AAV9 In Vivo.

Animals Blood Pressure Dependovirus / genetics Endothelial Cells Mice Mice, Transgenic Swine RNA, Guide, CRISPR-Cas Systems
endothelium subject terms: gene therapy vascular biology

Journal

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569

Informations de publication

Date de publication:
03 2022
Historique:
revised: 22 11 2021
received: 02 09 2021
pubmed: 14 1 2022
medline: 8 4 2022
entrez: 13 1 2022
Statut: ppublish

Résumé

Adeno-associated viruses (AAVs) are frequently used for gene transfer and gene editing in vivo, except for endothelial cells, which are remarkably resistant to unmodified AAV-transduction. AAVs are retargeted here toward endothelial cells by coating with second-generation polyamidoamine dendrimers (G2) linked to endothelial-affine peptides (CNN). G2

Identifiants

DOI: 10.1002/advs.202103867 PMID: 35023328 PMC: PMC8895123
pubmed: 35023328
doi: 10.1002/advs.202103867
pmc: PMC8895123
doi:

Substances chimiques

RNA, Guide, CRISPR-Cas Systems 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2103867

Subventions

Organisme : German Ministry for Education and Research
ID : 01GU1105A
Organisme : DZHK Large animal platform
Organisme : German Research Foundation
ID : SFB-TRR127-A2
Organisme : German Research Foundation
ID : SFB-TRR 267-B8
Organisme : German Research Foundation
ID : SFB1123-A1
Organisme : German Research Foundation
ID : INST 409/150-1
Organisme : German Research Foundation
Organisme : European Research Council
Pays : International

Informations de copyright

© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.

Références

Gene Ther. 2012 Aug;19(8):800-9
pubmed: 21956692
Basic Res Cardiol. 2018 Nov 15;114(1):2
pubmed: 30443826
Mol Pharm. 2013 Feb 4;10(2):606-18
pubmed: 23281933
Am J Hypertens. 2008 Dec;21(12):1288-91
pubmed: 18846043
Acta Physiol Scand. 2000 Jan;168(1):155-60
pubmed: 10691794
Gene Ther. 2009 Mar;16(3):311-9
pubmed: 19052631
J Clin Invest. 2011 Jun;121(6):2427-35
pubmed: 21576824
Sci Transl Med. 2011 Jul 20;3(92):92ra64
pubmed: 21775667
Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8532-7
pubmed: 27402766
N Engl J Med. 2017 Dec 7;377(23):2215-2227
pubmed: 29211678
Nat Protoc. 2013 Nov;8(11):2281-2308
pubmed: 24157548
Mol Ther. 2015 Jan;23(1):192-201
pubmed: 25322757
J Am Coll Cardiol. 2010 Jul 27;56(5):414-22
pubmed: 20650363
Nat Med. 2019 Mar;25(3):427-432
pubmed: 30778238
Adv Sci (Weinh). 2022 Mar;9(7):e2103867
pubmed: 35023328
J Virol. 2012 Jul;86(13):7326-33
pubmed: 22514350
Hum Gene Ther Methods. 2012 Feb;23(1):18-28
pubmed: 22428977
Nat Med. 2020 Feb;26(2):207-214
pubmed: 31988462
Nature. 2014 Feb 20;506(7488):382-6
pubmed: 24390344
Am J Cardiol. 2019 Apr 1;123(7):1134-1141
pubmed: 30658919
J Clin Invest. 2019 Jun 17;129(7):2775-2791
pubmed: 31205027
Genesis. 2007 Sep;45(9):593-605
pubmed: 17868096
Sci Rep. 2016 May 09;6:25533
pubmed: 27156886
Mol Ther. 2014 Apr;22(4):692-701
pubmed: 24352214
Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):
pubmed: 33658378
EMBO Mol Med. 2016 Jun 01;8(6):609-25
pubmed: 27137490
Mol Ther Methods Clin Dev. 2019 Jul 23;14:261-269
pubmed: 31453264
Nat Med. 2009 Oct;15(10):1215-8
pubmed: 19749771
Nat Med. 2018 Oct;24(10):1519-1525
pubmed: 30297904
Microsc Microanal. 2007 Oct;13(5):384-9
pubmed: 17900390
Nat Rev Immunol. 2007 Sep;7(9):678-89
pubmed: 17717539
Nature. 2019 May;569(7755):236-240
pubmed: 31043745
Circulation. 2013 Sep 3;128(10):1066-75
pubmed: 23897866
Circulation. 2011 Jul 19;124(3):304-13
pubmed: 21709064
J Exp Med. 2008 Jun 9;205(6):1435-46
pubmed: 18519646
Mol Ther Methods Clin Dev. 2016 Mar 30;5:16019
pubmed: 27069952
PLoS One. 2014 Jul 15;9(7):e102455
pubmed: 25025770
Mol Ther. 2008 Jun;16(6):1073-80
pubmed: 18414476
Science. 2018 Oct 5;362(6410):86-91
pubmed: 30166439
Nat Commun. 2015 Apr 20;6:6915
pubmed: 25892652
Hum Mol Genet. 2019 Oct 1;28(R1):R3-R14
pubmed: 31261383
Mol Ther. 2008 Dec;16(12):1953-9
pubmed: 18813281
Circulation. 2004 Feb 3;109(4):513-9
pubmed: 14732747
Circulation. 2013 Oct 8;128(15):1612-22
pubmed: 23969695
J Am Coll Cardiol. 2019 Jun 18;73(23):2990-3002
pubmed: 31196457
J Immunol. 2001 Aug 15;167(4):2268-74
pubmed: 11490014

Auteurs

Tarik Bozoglu (T)

Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.

Seungmin Lee (S)

Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.

Tilman Ziegler (T)

Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
ORCID: 0000-0003-2291-5861

Victoria Jurisch (V)

Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.

Sanne Maas (S)

DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Institute for Cardiovascular Prevention, Ludwigs-Maximilians-University, Munich, Germany.

Andrea Baehr (A)

Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
ORCID: 0000-0001-8075-8222

Rabea Hinkel (R)

Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Deutsches Primatenzentrum GmbH, Leibnitz-Institut für Primatenforschung, Department of Laboratory Animal Science, Göttingen, Germany.
ORCID: 0000-0002-2936-0400

Amelie Hoenig (A)

Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.

Anjana Hariharan (A)

Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.

Christina Inyeop Kim (CI)

Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.

Simon Decker (S)

Faculty of Life Sciences, Department of Pharmaceutical Sciences, Laboratory of MacroMolecular Cancer Therapeutics (MMCT), University of Vienna, Althanstrasse 14, Vienna, 1090, Austria.

Haider Sami (H)

Faculty of Life Sciences, Department of Pharmaceutical Sciences, Laboratory of MacroMolecular Cancer Therapeutics (MMCT), University of Vienna, Althanstrasse 14, Vienna, 1090, Austria.

Tobias Koppara (T)

Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.

Ruppert Oellinger (R)

Institute of Molecular Oncology and Functional Genomics, University Clinic rechts der Isar, Technical University of Munic, Germany.

Oliver J Müller (OJ)

Klinik für Innere Medizin III and DZHK (German Center for Cardiovascular Research), partner site Hamburg, Kiel, Lübeck., UKSH, Kiel, Germany.

Derk Frank (D)

Klinik für Innere Medizin III and DZHK (German Center for Cardiovascular Research), partner site Hamburg, Kiel, Lübeck., UKSH, Kiel, Germany.

Remco Megens (R)

Institute for Cardiovascular Prevention, Ludwigs-Maximilians-University, Munich, Germany.

Peter Nelson (P)

Medizinische Klinik und Poliklinik IV, Poliklinik Innenstadt, Ludwigs-Maximilians-University, Munich, Germany.

Christian Weber (C)

DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Institute for Cardiovascular Prevention, Ludwigs-Maximilians-University, Munich, Germany.

Angelika Schnieke (A)

Department of Animal Sciences, Chair of Livestock Biotechnology, School of Life Sciences Weihenstephan, Technical University Munich, Germany.

Markus Sperandio (M)

Walter Brendel Centre of Experimental Medicine and Institute of Cardiovascular Physiology and Pathophysiology, BioMedical Centre, Ludwig Maximilians University of Munich, Germany.

Gianluca Santamaria (G)

Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.

Roland Rad (R)

Institute of Molecular Oncology and Functional Genomics, University Clinic rechts der Isar, Technical University of Munic, Germany.

Alessandra Moretti (A)

Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
ORCID: 0000-0001-5782-7832

Karl-Ludwig Laugwitz (KL)

Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.

Oliver Soehnlein (O)

DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Institute for Cardiovascular Prevention, Ludwigs-Maximilians-University, Munich, Germany.
Institute for Experimental Pathology (ExPat), Center for Molecular Biology of Inflammation (ZMBE), WWU Münster, Germany.

Manfred Ogris (M)

Faculty of Life Sciences, Department of Pharmaceutical Sciences, Laboratory of MacroMolecular Cancer Therapeutics (MMCT), University of Vienna, Althanstrasse 14, Vienna, 1090, Austria.

Christian Kupatt (C)

Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University Munich, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
ORCID: 0000-0002-3611-1218

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Endothelial Retargeting of AAV9 In Vivo.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Pression sanguine › Endothelial Retargeting of AAV9 In Vivo.
questionsmedicales.fr › Virus › Virus à ADN › Parvoviridae › Parvovirinae › Dependovirus › Endothelial Retargeting of AAV9 In Vivo.
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Endothelial Retargeting of AAV9 In Vivo.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Endothelial Retargeting of AAV9 In Vivo.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Endothelial Retargeting of AAV9 In Vivo.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Endothelial Retargeting of AAV9 In Vivo.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Systèmes CRISPR-Cas, ARN, guide › Endothelial Retargeting of AAV9 In Vivo.