Glucose fluxes in glycolytic and oxidative pathways detected in vivo by deuterium magnetic resonance spectroscopy reflect proliferation in mouse glioblastoma.
Deuterium magnetic resonance spectroscopy
Glioblastoma
Glycolysis
Magnetic resonance imaging
Mitochondrial oxidation
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
07
2021
revised:
29
12
2021
accepted:
30
12
2021
pubmed:
14
1
2022
medline:
4
3
2022
entrez:
13
1
2022
Statut:
ppublish
Résumé
Glioblastoma multiforme (GBM), the most aggressive glial brain tumors, can metabolize glucose through glycolysis and mitochondrial oxidation pathways. While specific dependencies on those pathways are increasingly associated with treatment response, detecting such GBM subtypes in vivo remains elusive. Here, we develop a dynamic glucose-enhanced deuterium spectroscopy (DGE GL261 and CT2A glioma allografts were induced in immunocompetent mice and scanned in vivo at 9.4 Tesla, harnessing DGE MP-PCA denoising of in vivo DGE Our fast DGE
Identifiants
pubmed: 35026626
pii: S2213-1582(21)00376-4
doi: 10.1016/j.nicl.2021.102932
pmc: PMC8760481
pii:
doi:
Substances chimiques
Deuterium
AR09D82C7G
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102932Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.