SV2A PET Imaging Is a Noninvasive Marker for the Detection of Spinal Damage in Experimental Models of Spinal Cord Injury.


Journal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410

Informations de publication

Date de publication:
08 2022
Historique:
received: 14 09 2021
accepted: 30 11 2021
pubmed: 15 1 2022
medline: 4 8 2022
entrez: 14 1 2022
Statut: ppublish

Résumé

Traumatic spinal cord injury (SCI) is a neurologic condition characterized by long-term motor and sensory neurologic deficits as a consequence of an external physical impact damaging the spinal cord. Anatomic MRI is considered the gold-standard diagnostic tool to obtain structural information for the prognosis of acute SCI; however, it lacks functional objective information to assess SCI progression and recovery. In this study, we explored the use of synaptic vesicle glycoprotein 2A (SV2A) PET imaging to detect spinal cord lesions noninvasively after SCI.

Identifiants

pubmed: 35027368
pii: jnumed.121.263222
doi: 10.2967/jnumed.121.263222
pmc: PMC9364338
doi:

Substances chimiques

Biomarkers 0
Membrane Glycoproteins 0
Nerve Tissue Proteins 0
Pyrrolidinones 0
Sv2a protein, rat 0
Fluorodeoxyglucose F18 0Z5B2CJX4D

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1245-1251

Informations de copyright

© 2022 by the Society of Nuclear Medicine and Molecular Imaging.

Références

Neuroimage. 2021 Jun;233:117961
pubmed: 33741482
Nat Rev Dis Primers. 2017 Apr 27;3:17018
pubmed: 28447605
Neurosci Lett. 2016 May 16;621:126-132
pubmed: 27084688
Mayo Clin Proc. 2013 Nov;88(11):1204-12
pubmed: 24182701
J Nucl Med. 2011 Sep;52(9):1385-91
pubmed: 21852356
Exp Neurol. 2012 Jun;235(2):539-52
pubmed: 22465264
Neuroimage Clin. 2021;31:102692
pubmed: 33992987
Nat Med. 2004 Jul;10 Suppl:S10-7
pubmed: 15272267
Radiol Clin North Am. 2019 Mar;57(2):319-339
pubmed: 30709473
J Neurotrauma. 2012 Dec 10;29(18):2748-60
pubmed: 23176637
Mol Imaging. 2010 Apr;9(2):108-16
pubmed: 20236603
Lancet Neurol. 2019 Dec;18(12):1123-1135
pubmed: 31405713
Neuroimage. 2014 Aug 1;96:276-87
pubmed: 24736171
Biomed Phys Eng Express. 2020 May 06;6(4):045001
pubmed: 33444262
Neurosurg Focus. 2013 Jul;35(1):E2
pubmed: 23815247
World Neurosurg. 2020 Aug;140:574-590
pubmed: 32437998
Sci Transl Med. 2021 Oct 13;13(615):eabe5640
pubmed: 34644146
Neuroscientist. 2013 Aug;19(4):409-21
pubmed: 23204243
Nat Neurosci. 2017 Apr 25;20(5):637-647
pubmed: 28440805
J Spinal Cord Med. 2007;30(3):205-14
pubmed: 17684886
J Cereb Blood Flow Metab. 2020 Jun;40(6):1351-1362
pubmed: 31307287
Eur J Pharmacol. 2005 Sep 27;520(1-3):70-6
pubmed: 16125696
J Nucl Med. 2019 Dec;60(12):1780-1786
pubmed: 31101744
Neuroscientist. 2013 Apr;19(2):116-28
pubmed: 22730072
J Nucl Med. 2022 Jun;63(6):942-947
pubmed: 34531262
J Neurosci. 1994 Sep;14(9):5223-35
pubmed: 8083732
World Neurosurg. 2014 Dec;82(6):1351-8
pubmed: 23246741
EJNMMI Phys. 2022 May 3;9(1):32
pubmed: 35503134
Acta Neurobiol Exp (Wars). 2011;71(2):281-99
pubmed: 21731081
Neurosci Lett. 2019 Jan 19;691:44-50
pubmed: 30075287
Sci Transl Med. 2016 Jul 20;8(348):348ra96
pubmed: 27440727
Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9861-6
pubmed: 15210974
Front Neuroenergetics. 2014 Jan 09;5:13
pubmed: 24409143
Phys Med Rehabil Clin N Am. 2020 Aug;31(3):331-343
pubmed: 32624098
J Nucl Med. 2007 Feb;48(2):277-87
pubmed: 17268026
Evid Based Spine Care J. 2011 Feb;2(1):37-44
pubmed: 22956935
Front Neurol. 2019 Mar 22;10:282
pubmed: 30967837

Auteurs

Daniele Bertoglio (D)

Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.

Nicolas Halloin (N)

URPhyM-NARILIS, University of Namur, Namur, Belgium.

Stef De Lombaerde (S)

Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.
Department of Nuclear Medicine, Antwerp University Hospital, Antwerp, Belgium.

Aleksandar Jankovski (A)

Institute of NeuroScience, NEUR Division, Université Catholique de Louvain, Louvain, Belgium; and.
Department of Neurosurgery, CHU UCL Namur, Yvoir, Belgium.

Jeroen Verhaeghe (J)

Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.

Charles Nicaise (C)

URPhyM-NARILIS, University of Namur, Namur, Belgium.

Steven Staelens (S)

Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium; steven.staelens@uantwerpen.be.

Articles similaires

Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell
C-Reactive Protein Humans Biomarkers Inflammation
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Classifications MeSH