Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19.
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
14
03
2021
accepted:
29
11
2021
pubmed:
15
1
2022
medline:
25
2
2022
entrez:
14
1
2022
Statut:
ppublish
Résumé
The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13. This haplotype contains a splice variant of OAS1, which occurs in people of African ancestry independently of gene flow from Neanderthals. Using trans-ancestry fine-mapping approaches in 20,779 hospitalized cases, we demonstrate that this splice variant is likely to be the SNP responsible for the association at this locus, thus strongly implicating OAS1 as an effector gene influencing COVID-19 severity.
Identifiants
pubmed: 35027740
doi: 10.1038/s41588-021-00996-8
pii: 10.1038/s41588-021-00996-8
pmc: PMC8837537
doi:
Substances chimiques
2',5'-Oligoadenylate Synthetase
EC 2.7.7.84
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
125-127Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM008638
Pays : United States
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : UL1TR001878
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BBS/E/D/10002070
Organisme : NIDDK NIH HHS
ID : K25 DK128563
Pays : United States
Organisme : Gouvernement du Canada | Instituts de Recherche en Santé du Canada | CIHR Skin Research Training Centre (Skin Research Training Centre)
ID : 409511
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : K25DK128563
Organisme : Medical Research Council
ID : MC_PC_19025
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : UL1 TR001873
Pays : United States
Organisme : Gouvernement du Canada | Instituts de Recherche en Santé du Canada | CIHR Skin Research Training Centre (Skin Research Training Centre)
ID : 365825
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : UL1TR001873
Organisme : Medical Research Council
ID : MC_PC_19059
Pays : United Kingdom
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BBS/E/D/30002275
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2022. The Author(s).
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