Association of plasma tryptophan concentration with periaqueductal gray matter functional connectivity in migraine patients.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 01 2022
14 01 2022
Historique:
received:
13
05
2021
accepted:
14
12
2021
entrez:
15
1
2022
pubmed:
16
1
2022
medline:
1
3
2022
Statut:
epublish
Résumé
Altered periaqueductal gray matter (PAG) functional connectivity contributes to brain hyperexcitability in migraine. Although tryptophan modulates neurotransmission in PAG projections through its metabolic pathways, the effect of plasma tryptophan on PAG functional connectivity (PAG-FC) in migraine has not been investigated yet. In this study, using a matched case-control design PAG-FC was measured during a resting-state functional magnetic resonance imaging session in migraine without aura patients (n = 27) and healthy controls (n = 27), and its relationship with plasma tryptophan concentration (TRP) was assessed. In addition, correlations of PAG-FC with age at migraine onset, migraine frequency, trait-anxiety and depressive symptoms were tested and the effect of TRP on these correlations was explored. Our results demonstrated that migraineurs had higher TRP compared to controls. In addition, altered PAG-FC in regions responsible for fear-cascade and pain modulation correlated with TRP only in migraineurs. There was no significant correlation in controls. It suggests increased sensitivity to TRP in migraine patients compared to controls. Trait-anxiety and depressive symptoms correlated with PAG-FC in migraine patients, and these correlations were modulated by TRP in regions responsible for emotional aspects of pain processing, but TRP did not interfere with processes that contribute to migraine attack generation or attack frequency.
Identifiants
pubmed: 35031640
doi: 10.1038/s41598-021-04647-0
pii: 10.1038/s41598-021-04647-0
pmc: PMC8760301
doi:
Substances chimiques
Tryptophan
8DUH1N11BX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
739Subventions
Organisme : Development of scientific workshops of medical, health sciences and pharmaceutical educations
ID : EFOP-3.6.3-VEKOP-16-2017-00009
Organisme : Magyar Tudományos Akadémia
ID : 2017-1.2.1-NKP-2017-00002
Organisme : Nemzeti Kutatási, Fejlesztési és Innovaciós Alap
ID : ÚNKP-20-3-II-SE-51
Organisme : Ministry for Innovation and Technology in Hungary
ID : 2020-4.1.1.-TKP2020
Organisme : Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
ID : 2019-2.1.7-ERA-NET-2020-00005
Informations de copyright
© 2022. The Author(s).
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