Engineering surgical stitches to prevent bacterial infection.
Anti-Bacterial Agents
/ administration & dosage
Anti-Infective Agents, Local
/ administration & dosage
Bacterial Infections
/ etiology
Coated Materials, Biocompatible
/ administration & dosage
Drug Resistance, Bacterial
Metal Nanoparticles
Pseudomonas aeruginosa
/ drug effects
Staphylococcus aureus
/ drug effects
Surgical Wound Infection
/ etiology
Sutures
/ adverse effects
Technology, Pharmaceutical
/ methods
Triclosan
/ administration & dosage
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 01 2022
17 01 2022
Historique:
received:
30
07
2021
accepted:
14
12
2021
entrez:
18
1
2022
pubmed:
19
1
2022
medline:
5
3
2022
Statut:
epublish
Résumé
Surgical site infections (SSIs) account for a massive economic, physiological, and psychological burden on patients and health care providers. Sutures provide a surface to which bacteria can adhere, proliferate, and promote SSIs. Current methods for fighting SSIs involve the use of sutures coated with common antibiotics (triclosan). Unfortunately, these antibiotics have been rendered ineffective due to the increasing rate of antibiotic resistance. A promising new avenue involves the use of metallic nanoparticles (MNPs). MNPs exhibit low cytotoxicity and a strong propensity for killing bacteria while evading the typical antibiotic resistance mechanisms. In this work, we developed a novel MNPs dip-coating method for PDS-II sutures and explored the capabilities of a variety of MNPs in killing bacteria while retaining the cytocompatibility. Our findings indicated that our technique provided a homogeneous coating for PDS-II sutures, maintaining the strength, structural integrity, and degradability. The MNP coatings possess strong in vitro antibacterial properties against P aeruginosa and S. aureus-varying the %of dead bacteria from ~ 40% (for MgO NPs) to ~ 90% (for Fe
Identifiants
pubmed: 35039588
doi: 10.1038/s41598-022-04925-5
pii: 10.1038/s41598-022-04925-5
pmc: PMC8764053
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Infective Agents, Local
0
Coated Materials, Biocompatible
0
Triclosan
4NM5039Y5X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
834Informations de copyright
© 2022. The Author(s).
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