Higher-order structures of the foot-and-mouth disease virus RNA-dependent RNA polymerase required for genome replication.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
17 01 2022
17 01 2022
Historique:
received:
23
03
2021
accepted:
20
12
2021
entrez:
18
1
2022
pubmed:
19
1
2022
medline:
4
3
2022
Statut:
epublish
Résumé
Replication of many positive-sense RNA viruses occurs within intracellular membrane-associated compartments. These are thought to provide a favourable environment for replication to occur, concentrating essential viral structural and nonstructural components, as well as protecting these components from host-cell pathogen recognition and innate immune responses. However, the details of the molecular interactions and dynamics within these structures is very limited. One of the key components of the replication machinery is the RNA-dependent RNA polymerase, RdRp. This enzyme has been shown to form higher-order fibrils in vitro. Here, using the RdRp from foot-and-mouth disease virus (termed 3D
Identifiants
pubmed: 35039618
doi: 10.1038/s42003-021-02989-z
pii: 10.1038/s42003-021-02989-z
pmc: PMC8764057
doi:
Substances chimiques
RNA, Viral
0
RNA-Dependent RNA Polymerase
EC 2.7.7.48
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
61Subventions
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/K003801/1
Organisme : RCUK | Medical Research Council (MRC)
ID : MC_UU_12014/7
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/S007229/1
Organisme : Medical Research Council
ID : MR/M000451/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/P001459/1
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/F01614X/1
Organisme : Wellcome Trust (Wellcome)
ID : 096670/Z/11/Z
Organisme : Wellcome Trust (Wellcome)
ID : 108466/Z/15/Z
Informations de copyright
© 2022. The Author(s).
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