Screening-detected positive serology for celiac disease: a real clinical challenge.
Journal
European journal of gastroenterology & hepatology
ISSN: 1473-5687
Titre abrégé: Eur J Gastroenterol Hepatol
Pays: England
ID NLM: 9000874
Informations de publication
Date de publication:
01 12 2021
01 12 2021
Historique:
entrez:
20
1
2022
pubmed:
21
1
2022
medline:
12
4
2022
Statut:
ppublish
Résumé
According to European Society for Paediatric Gastroenterology, Hepatology, and Nutrition 2020 criteria for celiac disease diagnosis, the small bowel biopsy (SBB) can be omitted in selected circumstances, even in asymptomatic patients. Hence, we have conducted a retrospective study to identify the histological findings of the asymptomatic patients with antitransglutaminase IgA antibodies 10 times above the upper limit of normal and positive antiendomisium antibodies; 5/24 patients fulfilling these criteria had, however, a nonconclusive SBB and were diagnosed with potential celiac disease. The nonbiopsy approach in these cases needs to be carefully evaluated and the risk of overdiagnosis pondered as the management and evolution of potential celiac disease cases is still a matter of study.
Identifiants
pubmed: 35048660
doi: 10.1097/MEG.0000000000002093
pii: 00042737-202112001-00135
doi:
Substances chimiques
Autoantibodies
0
Immunoglobulin A
0
Transglutaminases
EC 2.3.2.13
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e999-e1002Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Références
Husby S, Koletzko S, Korponay-Szabó IR, Mearin ML, Phillips A, Shamir R, et al.; ESPGHAN Working Group on Coeliac Disease Diagnosis; ESPGHAN Gastroenterology Committee; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. European society for pediatric gastroenterology, hepatology, and nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012; 54:136–160.
Husby S, Koletzko S, Korponay-Szabó I, Kurppa K, Mearin ML, Ribes-Koninckx C, et al. European society paediatric gastroenterology, hepatology and nutrition guidelines for diagnosing coeliac disease 2020. J Pediatr Gastroenterol Nutr 2020; 70:141–156.
Ravelli A, Villanacci V. Tricks of the trade: how to avoid histological pitfalls in celiac disease. Pathol Res Pract 2012; 208:197–202.
Hill PG, Holmes GK. Coeliac disease: a biopsy is not always necessary for diagnosis. Aliment Pharmacol Ther 2008; 27:572–577.
Werkstetter KJ, Korponay-Szabó IR, Popp A, Villanacci V, Salemme M, Heilig G, et al.; ProCeDE study group. Accuracy in diagnosis of celiac disease without biopsies in clinical practice. Gastroenterology 2017; 153:924–935.
Wolf J, Petroff D, Richter T, Auth MKH, Uhlig HH, Laass MW, et al. Validation of antibody-based strategies for diagnosis of pediatric celiac disease without biopsy. Gastroenterology 2017; 153:410–419.e17.
Lionetti E, Castellaneta S, Francavilla R, Pulvirenti A, Tonutti E, Amarri S, et al.; SIGENP (Italian Society of Pediatric Gastroenterology, Hepatology, and Nutrition) Working Group on Weaning and CD Risk. Introduction of gluten, HLA status, and the risk of celiac disease in children. N Engl J Med 2014; 371:1295–1303.
Vriezinga SL, Auricchio R, Bravi E, Castillejo G, Chmielewska A, Crespo Escobar P, et al. Randomized feeding intervention in infants at high risk for celiac disease. N Engl J Med 2014; 371:1304–1315.
Donat E, Ramos JM, Sánchez-Valverde F, Moreno A, Martinez MJ, Leis R, et al.; SEGHNP Working Group on Coeliac Disease. ESPGHAN 2012 guidelines for coeliac disease diagnosis: validation through a retrospective spanish multicentric study. J Pediatr Gastroenterol Nutr 2016; 62:284–291.
Roca M, Donat E, Marco-Maestud N, Masip E, Hervás-Marín D, Ramos D, et al. Efficacy study of anti-endomysium antibodies for celiac disease diagnosis: a retrospective study in a spanish pediatric population. J Clin Med 2019; 11:8.
Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol 1999; 11:1185–1194.
Korponay-Szabó IR, Halttunen T, Szalai Z, Laurila K, Király R, Kovács JB, et al. In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies. Gut 2004; 53:641–648.
Salmi TT, Collin P, Järvinen O, Haimila K, Partanen J, Laurila K, et al. Immunoglobulin A autoantibodies against transglutaminase 2 in the small intestinal mucosa predict forthcoming coeliac disease. Aliment Pharmacol Ther 2006; 24:541–552.
Donat E, Roca M, Masip E, Polo B, Ramos D, Ribes-Koninckx C. Common problems found in the methodological approach to small bowel biopsies in the diagnosis of celiac disease. J Pediatr Gastroenterol Nutr 2019; 69:336–338.
Mandile R, Discepolo V, Scapaticci S, Del Vecchio MR, Maglio MA, Greco L, et al. The effect of gluten-free diet on clinical symptoms and the intestinal mucosa of patients with potential celiac disease. J Pediatr Gastroenterol Nutr 2018; 66:654–656.
Auricchio R, Mandile R, Del Vecchio MR, Scapaticci S, Galatola M, Maglio M, et al. Progression of celiac disease in children with antibodies against tissue transglutaminase and normal duodenal architecture. Gastroenterology 2019; 157:413–420.e3.
Borrelli M, Maglio M, Korponay-Szabó IR, Vass V, Mearin ML, Meijer C, et al. Intestinal anti-transglutaminase 2 immunoglobulin A deposits in children at risk for coeliac disease (CD): data from the PreventCD study. Clin Exp Immunol 2018; 191:311–317.
Trovato CM, Montuori M, Anania C, Barbato M, Vestri AR, Guida S, et al. Are ESPGHAN “biopsy-sparing” guidelines for celiac disease also suitable for asymptomatic patients? Am J Gastroenterol 2015; 110:1485–1489.
Paul SP, Sandhu BK, Spray CH, Basude D, Ramani P. Evidence supporting serology-based pathway for diagnosing celiac disease in asymptomatic children from high-risk groups. J Pediatr Gastroenterol Nutr 2018; 66:641–644.