Tilting the Balance: Therapeutic Prospects of CD83 as a Checkpoint Molecule Controlling Resolution of Inflammation.
Animals
Antigens, CD
/ chemistry
Biomarkers
Dendritic Cells
/ immunology
Diagnosis, Differential
Disease Management
Disease Susceptibility
Gene Expression Regulation
Humans
Immune Checkpoint Proteins
/ genetics
Immunoglobulins
/ chemistry
Inflammation
/ diagnosis
Lymphocytes
/ immunology
Membrane Glycoproteins
/ chemistry
Signal Transduction
Structure-Activity Relationship
CD83 Antigen
CD83
IDO/TGF-β-axis
adoptive transfer
pro-resolving macrophages
resolution of inflammation
transplantation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Jan 2022
10 Jan 2022
Historique:
received:
08
12
2021
revised:
05
01
2022
accepted:
08
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
8
2
2022
Statut:
epublish
Résumé
Chronic inflammatory diseases and transplant rejection represent major challenges for modern health care. Thus, identification of immune checkpoints that contribute to resolution of inflammation is key to developing novel therapeutic agents for those conditions. In recent years, the CD83 (cluster of differentiation 83) protein has emerged as an interesting potential candidate for such a "pro-resolution" therapy. This molecule occurs in a membrane-bound and a soluble isoform (mCD83 and sCD83, respectively), both of which are involved in resolution of inflammation. Originally described as a maturation marker on dendritic cells (DCs), mCD83 is also expressed by activated B and T cells as well as regulatory T cells (Tregs) and controls turnover of MHC II molecules in the thymus, and thereby positive selection of CD4
Identifiants
pubmed: 35054916
pii: ijms23020732
doi: 10.3390/ijms23020732
pmc: PMC8775349
pii:
doi:
Substances chimiques
Antigens, CD
0
Biomarkers
0
Immune Checkpoint Proteins
0
Immunoglobulins
0
Membrane Glycoproteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1181 project B03
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK 2599 project P3
Organisme : Deutsche Forschungsgemeinschaft
ID : STE 432/11-1
Organisme : Deutsche Forschungsgemeinschaft
ID : STE 432/15-1
Organisme : Deutsche Forschungsgemeinschaft
ID : ZI 1225/1-1
Organisme : Deutsche Forschungsgemeinschaft
ID : ZI 1225/2-1
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK 2504, project B1
Organisme : IZKF from the Universitätsklinikum Erlangen
ID : Grant A89
Organisme : Else Kröner-Fresenius-Stiftung
ID : 2020_EKEA.81
Organisme : Bavarian Equal Opportunities Sponsorship - Realisierung von Chancengleichheit von Frauen in Forschung und Lehre (FFL) - Realization Equal Opportunities for Women in Research and Teaching
ID : Bavarian Equal Opportunities Sponsorship - Realisierung von Chancengleichheit von Frauen in Forschung und Lehre (FFL) - Realization Equal Opportunities for Women in Research and Teaching
Références
Front Cell Dev Biol. 2021 Jan 22;8:605713
pubmed: 33585445
Immunobiology. 2004;209(1-2):129-40
pubmed: 15481147
J Immunol. 2016 May 1;196(9):3581-94
pubmed: 26983787
Cancers (Basel). 2020 Aug 13;12(8):
pubmed: 32823589
Am J Transplant. 2021 Sep 1;:
pubmed: 34467638
Am J Physiol Cell Physiol. 2020 Sep 1;319(3):C510-C532
pubmed: 32667864
J Immunol. 2008 May 1;180(9):5890-7
pubmed: 18424708
J Cell Biol. 2018 Apr 2;217(4):1395-1410
pubmed: 29371232
Cell Death Dis. 2018 Jun 4;9(6):665
pubmed: 29867198
Front Immunol. 2020 Apr 17;11:721
pubmed: 32362900
Transpl Immunol. 2021 Feb;64:101351
pubmed: 33171217
J Exp Med. 2005 Oct 3;202(7):941-53
pubmed: 16203865
Front Immunol. 2019 Jul 24;10:1751
pubmed: 31404274
Immunobiology. 2013 Nov;218(11):1411-5
pubmed: 23886695
Tissue Antigens. 2006 Jan;67(1):57-60
pubmed: 16451202
J Innate Immun. 2021;13(5):295-305
pubmed: 34182560
Semin Immunopathol. 2019 Nov;41(6):711-726
pubmed: 31732775
Front Immunol. 2019 Jun 07;10:1312
pubmed: 31231400
EMBO Mol Med. 2013 May;5(5):661-74
pubmed: 23592557
J Immunol. 2013 Aug 15;191(4):1965-75
pubmed: 23851696
JCI Insight. 2018 Jun 7;3(11):
pubmed: 29875316
Blood. 2000 Dec 1;96(12):3958-63
pubmed: 11090084
J Immunol. 2005 Jun 1;174(11):6672-6
pubmed: 15905506
Front Immunol. 2019 Jun 25;10:1442
pubmed: 31293592
J Immunol. 1992 Jul 15;149(2):735-42
pubmed: 1378080
Trends Immunol. 2002 Jun;23(6):273-5
pubmed: 12072358
J Neuroimmunol. 2018 Jul 15;320:11-14
pubmed: 29759135
J Exp Med. 2016 Aug 22;213(9):1695-703
pubmed: 27503069
Immunobiology. 2015 Feb;220(2):270-9
pubmed: 25151500
Cell. 2019 Apr 18;177(3):541-555.e17
pubmed: 30955887
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18778-83
pubmed: 22065790
Viruses. 2020 Jan 16;12(1):
pubmed: 31963276
Nat Rev Drug Discov. 2016 Aug;15(8):551-67
pubmed: 27020098
Phytother Res. 2021 Feb;35(2):835-845
pubmed: 32929778
Transpl Int. 2007 Mar;20(3):266-76
pubmed: 17291220
J Exp Med. 2001 Dec 17;194(12):1813-21
pubmed: 11748282
Cell Mol Immunol. 2017 Feb;14(2):146-179
pubmed: 27721455
Nat Nanotechnol. 2021 Jan;16(1):37-46
pubmed: 33349685
Immunol Lett. 2008 Oct 30;120(1-2):87-95
pubmed: 18675848
J Clin Invest. 2019 May 20;129(7):2619-2628
pubmed: 31107246
Gut. 2010 May;59(5):595-604
pubmed: 20427394
Haematologica. 2018 Apr;103(4):655-665
pubmed: 29351987
N Engl J Med. 2011 Dec 8;365(23):2205-19
pubmed: 22150039
Front Immunol. 2021 May 04;12:656452
pubmed: 34017333
Nat Immunol. 2017 Jul 19;18(8):826-831
pubmed: 28722720
Sci Rep. 2017 Oct 16;7(1):12895
pubmed: 29038541
Int Immunol. 2018 Oct 29;30(11):511-528
pubmed: 30165385
J Exp Med. 2019 May 6;216(5):1170-1181
pubmed: 30910796
Transplantation. 2010 Dec 27;90(12):1278-85
pubmed: 21079552
J Immunol. 2016 Dec 15;197(12):4613-4625
pubmed: 27837105
Int Immunol. 2007 Aug;19(8):977-92
pubmed: 17804692
Nat Rev Rheumatol. 2019 Jun;15(6):319
pubmed: 31028371
Nat Commun. 2018 Aug 15;9(1):3261
pubmed: 30111884
J Immunol Res. 2019 Apr 24;2019:5763430
pubmed: 31179346
J Gen Virol. 2014 Jun;95(Pt 6):1366-1375
pubmed: 24643878
J Exp Med. 1999 Jun 7;189(11):1777-82
pubmed: 10359581
J Immunol. 2007 Oct 1;179(7):4550-62
pubmed: 17878352
J Immunol. 2020 Jun 15;204(12):3217-3226
pubmed: 32341061
Curr Opin Gastroenterol. 2013 Mar;29(2):146-52
pubmed: 23283180
Nat Commun. 2021 Jan 12;12(1):301
pubmed: 33436596
Mucosal Immunol. 2015 Mar;8(2):414-28
pubmed: 25204675
Semin Immunol. 2016 Apr;28(2):137-45
pubmed: 27021499
Immunology. 2021 Jul;163(3):310-322
pubmed: 33539546
Trends Immunol. 2019 Mar;40(3):212-227
pubmed: 30772190
Lancet. 2020 May 23;395(10237):1627-1639
pubmed: 32446407
J Immunol. 2017 Mar 15;198(6):2286-2301
pubmed: 28193829
Leuk Res. 2009 Aug;33(8):1089-95
pubmed: 19195701
J Exp Med. 2011 Jan 17;208(1):149-65
pubmed: 21220452
Front Microbiol. 2017 Feb 01;8:119
pubmed: 28203230
J Immunol. 2004 Sep 1;173(5):2995-3001
pubmed: 15322158
Front Immunol. 2018 Jul 09;9:1567
pubmed: 30050530
Transplantation. 2010 Dec 27;90(12):1286-93
pubmed: 21076370
J Exp Med. 2016 Aug 22;213(9):1685-94
pubmed: 27503071
Immunol Rev. 2014 Mar;258(1):132-44
pubmed: 24517430
Mol Med Rep. 2015 Sep;12(3):3309-3314
pubmed: 25997495
Semin Immunopathol. 2019 Nov;41(6):675-679
pubmed: 31720751
Int Immunol. 2000 Sep;12(9):1347-51
pubmed: 10967030
Front Immunol. 2016 Apr 26;7:160
pubmed: 27199985
Int Immunol. 2014 May;26(5):283-9
pubmed: 24370470
Mol Med. 2012 Jul 18;18:834-42
pubmed: 22481272
Front Immunol. 2019 Apr 02;10:633
pubmed: 31001257
Nucleic Acids Res. 2015 Jan;43(Database issue):D204-12
pubmed: 25348405
Transplantation. 2010 Dec 15;90(11):1145-56
pubmed: 20861805
J Exp Med. 2004 Aug 2;200(3):345-51
pubmed: 15289503
Nat Rev Gastroenterol Hepatol. 2017 May;14(5):269-278
pubmed: 28144028
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19446-51
pubmed: 18042719
Biochem J. 2005 Jan 1;385(Pt 1):85-93
pubmed: 15320871
JCI Insight. 2019 Oct 17;4(20):
pubmed: 31527313
Mucosal Immunol. 2014 Jul;7(4):1006-18
pubmed: 24424524
Arthritis Res Ther. 2020 Mar 12;22(1):46
pubmed: 32164778
Nat Immunol. 2011 Aug 18;12(9):809-11
pubmed: 21852775
Sci Transl Med. 2014 May 7;6(235):235ra60
pubmed: 24807557
Leuk Res. 2004 Mar;28(3):237-41
pubmed: 14687618
Immunogenetics. 2019 Mar;71(3):197-201
pubmed: 30377751
J Biol Chem. 2009 Sep 11;284(37):24914-24
pubmed: 19602726
Front Immunol. 2018 Jun 15;9:1363
pubmed: 29963055
FEBS Lett. 1999 Nov 19;461(3):211-6
pubmed: 10567699
Cell. 2002 Mar 22;108(6):755-67
pubmed: 11955430
Int Immunol. 2001 Jul;13(7):959-67
pubmed: 11431426