Antibodies against Angiotensin II Type 1 and Endothelin 1 Type A Receptors in Cardiovascular Pathologies.
Autoantibodies
/ metabolism
Cardiovascular Diseases
/ immunology
Collagen
/ metabolism
Humans
Interleukin-6
/ metabolism
Interleukin-8
/ metabolism
Reactive Oxygen Species
/ metabolism
Receptor, Angiotensin, Type 1
/ immunology
Receptor, Endothelin A
/ immunology
Tumor Necrosis Factor-alpha
/ metabolism
AT1R
ETAR
angiotensin
autoantibodies
cardiovascular
coronary
endothelin
preeclampsia
receptors
transplantation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Jan 2022
15 Jan 2022
Historique:
received:
05
01
2022
accepted:
14
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
5
2
2022
Statut:
epublish
Résumé
Angiotensin II receptor type 1 (AT1R) and endothelin-1 receptor type A (ETAR) are G-protein-coupled receptors (GPCRs) expressed on the surface of a great variety of cells: immune cells, vascular smooth cells, endothelial cells, and fibroblasts express ETAR and AT1R, which are activated by endothelin 1 (ET1) and angiotensin II (AngII), respectively. Certain autoantibodies are specific for these receptors and can regulate their function, thus being known as functional autoantibodies. The function of these antibodies is similar to that of natural ligands, and it involves not only vasoconstriction, but also the secretion of proinflammatory cytokines (such as interleukin-6 (IL6), IL8 and TNF-α), collagen production by fibroblasts, and reactive oxygen species (ROS) release by fibroblasts and neutrophils. The role of autoantibodies against AT1R and ETAR (AT1R-AAs and ETAR-AAs, respectively) is well described in the pathogenesis of many medical conditions (e.g., systemic sclerosis (SSc) and SSc-associated pulmonary hypertension, cystic fibrosis, and allograft dysfunction), but their implications in cardiovascular diseases are still unclear. This review summarizes the current evidence regarding the effects of AT1R-AAs and ETAR-AAs in cardiovascular pathologies, highlighting their roles in heart transplantation and mechanical circulatory support, preeclampsia, and acute coronary syndromes.
Identifiants
pubmed: 35055116
pii: ijms23020927
doi: 10.3390/ijms23020927
pmc: PMC8778295
pii:
doi:
Substances chimiques
AGTR1 protein, human
0
Autoantibodies
0
CXCL8 protein, human
0
IL6 protein, human
0
Interleukin-6
0
Interleukin-8
0
Reactive Oxygen Species
0
Receptor, Angiotensin, Type 1
0
Receptor, Endothelin A
0
TNF protein, human
0
Tumor Necrosis Factor-alpha
0
Collagen
9007-34-5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Padua
ID : BIRD2020_1
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